Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-Methylmercaptopurine riboside | and analogs | Mus musculus | |
6-methylmercaptopurine riboside phosphate | product inhibition, competitive with respect to ATP and noncompetitive with respect to 6-methylmercaptopurine ribonucleoside | Mus musculus | |
7-beta-D-ribofuranosyl-pyrrolo-(2,3-d)-pyrimidine | competitive with respect to 6-methylmercaptopurine riboside and noncompetitive with respect to ATP | Mus musculus | |
adenosine | competitive with respect to 6-methylmercaptopurine riboside | Mus musculus | |
ADP | noncompetitive with respect to ATP and 6-methylmercaptopurine ribonucleoside at low concentrations of the substrates; product inhibition | Mus musculus | |
ATP-analogs | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic study | Mus musculus | |
0.01 | - |
6-Methylmercaptopurine riboside | pH 6.0, 37ºC | Mus musculus | |
0.025 | - |
ATP | pH 6.0, 37ºC | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate fractionation and gel filtration, 15-20fold purification | Mus musculus |
partial | Mus musculus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + adenosine = ADP + AMP | mechanism | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
Storage Stability | Organism |
---|---|
-20°C, partially purified, 1 year | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 6-methylmercaptopurine riboside | - |
Mus musculus | ADP + 6-methylmercaptopurine-D-riboside 5'-phosphate | - |
? | |
ATP + adenosine | - |
Mus musculus | ADP + AMP | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
7-beta-D-ribofuranosyl-pyrrolo-(2,3-d)-pyrimidine | pH 6.0, 37ºC | Mus musculus | |
0.06 | - |
ADP | pH 6.0, 37ºC | Mus musculus | |
0.16 | - |
6-methylmercaptopurine riboside phosphate | pH 6.0, 37ºC | Mus musculus | |
0.26 | - |
adenosine | pH 6.0, 37ºC | Mus musculus |