Any feedback?
Literature summary for 2.7.1.20 extracted from
- Partial purification and properties of rat heart adenosine kinase (1977), Arch. Int. Physiol. Biochim., 85, 557-569.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dipyridamole | at high adenosine levels | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 8-azaadenosine | - |
Rattus norvegicus | |
| dipyridamole | at low adenosine levels | Rattus norvegicus | |
| Mg2+ | strong inhibition above 1 mM | Rattus norvegicus | |
| Mn2+ | strong inhibition above 1 mM | Rattus norvegicus | |
| NSC 113939 | - |
Rattus norvegicus | |
| NSC 113940 | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00015 | 0.0005 | adenosine | - |
Rattus norvegicus | |
| 0.0033 | - |
adenosine | in the presence of dipyridamol | Rattus norvegicus | |
| 0.1 | - |
ATP | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | requirement | Rattus norvegicus | |
| Mg2+ | 0.5 mM | Rattus norvegicus | |
| Mn2+ | can partially substitute for Mg2+ | Rattus norvegicus | |
| Mn2+ | activation | Rattus norvegicus | |
| Mn2+ | at 0.5 mM | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 39000 | - |
myocard | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial, 80fold purification | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | myocard | Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + adenosine | - |
Rattus norvegicus | ADP + AMP | - |
? | |
| CTP + adenosine | less efficient than ATP | Rattus norvegicus | CDP + AMP | - |
? | |
| GTP + adenosine | better activity than with ATP | Rattus norvegicus | GDP + AMP | - |
? | |
| ITP + adenosine | better activity than with ATP | Rattus norvegicus | IDP + AMP | - |
? | |
| UTP + adenosine | less efficient than ATP | Rattus norvegicus | UDP + AMP | - |
? | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
