Ligand adenosine

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of adenosine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H13N5O4
adenosine
OIRDTQYFTABQOQ-KQYNXXCUSA-N
Synonyms:
3-beta-ribofuranosyladenine


Show all pahtways known for Show all BRENDA pathways known for adenosine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (82 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
adenosine + O2 = 9-riburonosyladenine + H2O2
show the reaction diagram
-
tuberculosinyl diphosphate + adenosine = 1-tuberculosinyladenosine + diphosphate
show the reaction diagram
-
adenosine + H2O = 6-aminopurine + D-ribofuranose
show the reaction diagram
-
adenosine + H2O = inosine + NH3
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (70 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N6-(DELTA2-isopentenyl)adenosine + FAD + H2O = adenosine + 3-methylbut-2-enal + FADH2
show the reaction diagram
-
-
S-adenosyl-L-methionine + H2O = adenosine + L-methionine + H+
show the reaction diagram
-
-
AMP + thymidine = adenosine + dTMP
show the reaction diagram
-
-
3'-AMP + H2O = adenosine + phosphate
show the reaction diagram
-
S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine
show the reaction diagram
-
-
5'-AMP + H2O = adenosine + phosphate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (310 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
adenosine + O2 = 9-riburonosyladenine + H2O
show the reaction diagram
-
adenosine + O2 = 9-riburonosyladenine + H2O2
show the reaction diagram
-
2'-deoxycytidine + adenosine = 2'-deoxyadenosine + cytosine
show the reaction diagram
-
tuberculosinyl diphosphate + adenosine = 1-tuberculosinyladenosine + diphosphate
show the reaction diagram
-
AMP + adenosine = adenosine + AMP
show the reaction diagram
-
ATP + adenosine = ADP + adenosine 5'-phosphate
show the reaction diagram
-
3 adenosine = ?
show the reaction diagram
-
adenosine + H2O = adenine + D-ribose
show the reaction diagram
-
adenosine + H2O = adenine + D-ribose
show the reaction diagram
-
adenosine + H2O = ?
show the reaction diagram
-
adenosine + H2O = D-ribose + adenine
show the reaction diagram
-
adenosine + H2O = adenine + D-ribose
show the reaction diagram
-
adenosine + H2O = inosine + NH3
show the reaction diagram
adenosine + H2O = inosine + NH3
show the reaction diagram
-
adenosine + H2O = inosine + NH3
show the reaction diagram
-
adenosine + H2O = inosine + NH3
show the reaction diagram
-
adenosine + H2O = inosine + NH3
show the reaction diagram
-
adenosine + H2O = ?
show the reaction diagram
-
adenosine + H2O = inosine + NH3
show the reaction diagram
-
adenosine + H2O = inosine + NH3
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (282 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 [Fe(II)-cytochrome b5] + 2 H+ + N6-hydroxyadenosine = 2 [Fe(III)-cytochrome b5] + H2O + adenosine
show the reaction diagram
-
-
adenosine N-oxide + electron donor = adenosine + H2O + oxidized electron donor
show the reaction diagram
-
AMP + trans-farnesyl diphosphate = adenosine + trans-farnesyl triphosphate
show the reaction diagram
-
-
(A)40 + 38 H2O = adenosine + 39 AMP
show the reaction diagram
-
-
3'AMP + H2O = adenosine + phosphate
show the reaction diagram
-
AMP + H2O = adenosine + phosphate
show the reaction diagram
-
AMP + H2O = adenosine + phosphate
show the reaction diagram
-
-
AMP + H2O = adenosine + phosphate
show the reaction diagram
-
-
2'-AMP + H2O = adenosine + phosphate
show the reaction diagram
-
-
NAD+ + H2O = adenosine + nicotinamide + ?
show the reaction diagram
-
-
S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine
show the reaction diagram
-
3'-AMP + H2O = adenosine + phosphate
show the reaction diagram
-
-
cAMP + H2O = adenosine + phosphate
show the reaction diagram
-
-
AMP + H2O = adenosine + phosphate
show the reaction diagram
-
AMP + H2O = adenosine + phosphate
show the reaction diagram
-
ApA + H2O = 3'-AMP + adenosine
show the reaction diagram
-
-
GpA + H2O = guanosine 3'-phosphate + adenosine
show the reaction diagram
-
-
AMP + H2O = adenosine + phosphate
show the reaction diagram
-
-

Enzyme Cofactor/Cosubstrate (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (72 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
very weak activation
-
adenosine activates PI3K and induces Akt phosphorylation leading to induction of hemeoxygenase-1, HO-1, expression in microglia. Adenosine acts as an endogenous regulator of brain inflammation via modulation of microglial reactive oxygen species production, mechanism, overview
-
slight activation
-
adenosine-induced vasodilation in cerebral microvessesls involves cGMP and cGMP-dependent protein kinase
-
activation by nucleotides, most efficient in presence of two different nucleotides
-
less effective than ATP
-
2',3'-cyclic nucleotide phosphodiesterase activity
-