Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

No. of entries

Information on EC 2.1.1.6 - catechol O-methyltransferase

for references in articles please use BRENDA:EC2.1.1.6

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
catechol-o-methyltransferase, catechol-o-methyl transferase, catechol o-methyltransferase, s-comt, mb-comt, comt1, comt i, comt ii, catechol methyltransferase, comt2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
3,5-dimethoxytoluene biosynthesis, betaxanthin biosynthesis, dopamine degradation, guaiacol biosynthesis, L-dopa degradation I (mammalian), noradrenaline and adrenaline degradation