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Literature summary for 2.1.1.6 extracted from

  • Savitz, J.B.; van der Merwe, L.; Newman, T.K.; Solms, M.; Stein, D.J.; Ramesar, R.S.
    The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity? (2008), Int. J. Neuropsychopharmacol., 11, 149-161.
    View publication on PubMed

Application

Application Comment Organism
medicine the functional catechol-O-methyltransferase (COMT) Val158Met polymorphism interacts significantly with total Childhood Trauma Questionnaire abuse scores to impact perceived dissociation. The Val/Val genotype is associated with increasing levels of dissociation in participants exposed to higher levels of childhood trauma. The opposite is observed in people with Met/Met genotypes who display decreased dissociation with increasing self-reported childhood trauma. COMT Val158Met polymorphism is involved in mediating the relationship between trauma and psychopathology Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Synonyms

Synonyms Comment Organism
COMT
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Homo sapiens