Literature summary for 2.1.1.6 extracted from

Moskovitz, J.; Walss-Bass, C.; Cruz, D.A.; Thompson, P.M.; Hairston, J.; Bortolato, M.
The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion (2015), Neuropathol. Appl. Neurobiol., 41, 941-951.

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Application

Application	Comment	Organism
medicine	best-characterized single nucleotide polymorphism of the COMT gene consists of a valine-to-methionine substitution at codon 108/158. In homozygous carriers of Met, but not Val alleles, the activity of COMT and methionine sulfoxide reductase are significantly correlated throughout all tested brain regions	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

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Release 2023.1 (January 2023)