Inhibitors | Comment | Organism | Structure |
---|---|---|---|
13-hydroxy-36-(trifluoromethyl)-14H-[11,22:24,32-terpyridin]-14-one | - |
Homo sapiens | |
3-hydroxy-4'-phenyl-4H-[1,2'-bipyridin]-4-one | potent inhibitor with sufficient in vivo exposure to significantly affect the dopamine metabolites homovanillic acid and dihydroxyphenylacetic acid | Homo sapiens | |
4'-(1-benzyl-1H-pyrazol-4-yl)-3-hydroxy-4H-[1,2'-bipyridin]-4-one | - |
Homo sapiens | |
4'-(3,4-dichlorophenyl)-3-hydroxy-4H-[1,2'-bipyridin]-4-one | - |
Homo sapiens | |
4'-fluoro-3-hydroxy-5'-phenyl-4H-[1,3'-bipyridin]-4-one | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21964 | - |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000035 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4'-(3,4-dichlorophenyl)-3-hydroxy-4H-[1,2'-bipyridin]-4-one | |
0.00004 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3-hydroxy-4'-phenyl-4H-[1,2'-bipyridin]-4-one | |
0.0000495 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4'-(1-benzyl-1H-pyrazol-4-yl)-3-hydroxy-4H-[1,2'-bipyridin]-4-one | |
0.000055 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4'-fluoro-3-hydroxy-5'-phenyl-4H-[1,3'-bipyridin]-4-one | |
0.000084 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 13-hydroxy-36-(trifluoromethyl)-14H-[11,22:24,32-terpyridin]-14-one | |
0.000946 | - |
soluble isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4'-fluoro-3-hydroxy-5'-phenyl-4H-[1,3'-bipyridin]-4-one | |
0.00302 | - |
soluble isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3-hydroxy-4'-phenyl-4H-[1,2'-bipyridin]-4-one |