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Literature summary for 2.1.1.6 extracted from

  • Salama, S.A.; Kamel, M.W.; Botting, S.; Salih, S.M.; Borahay, M.A.; Hamed, A.A.; Kilic, G.S.; Saeed, M.; Williams, M.Y.; Diaz-Arrastia, C.R.
    Catechol-O-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells (2009), PLoS ONE, 4, e7356.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.6

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
leiomyoma cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
COMT
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function COMT over expression stabilizes microtubules, ameliorates 17beta-estradiol-induced proliferation, inhibits estrogen receptor alpha and progesterone receptor signaling, and reduces hypoxia-inducible factor-1alpha and tissue necrosis factor-alpha-induced aromatase (CYP19) expression in human uterine leiomyoma cells Homo sapiens