Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.6 extracted from

  • Lu, H.; Meng, X.; Yang, C.S.
    Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate (2003), Drug Metab. Dispos., 31, 572-579.
    View publication on PubMed
Search for more literature for 2.1.1.6

Inhibitors

Inhibitors Comment Organism Structure
(-)-epigallocatechin gallate potent inhibitor with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa
(-)-epigallocatechin gallate-4''-O-glucuronide with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa
(-)-epigallocatechin gallate-7-O-glucuronide with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa
(-)epicatechin gallate3,5-dinitrocatechol with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa
4''-O-methyl epigallocatechin gallate potent inhibitor with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa
4',3'',4''-tri-O-methyl epigallocatechin gallate substrate: epigallocatechin Sus scrofa
4',4''-di-O-methyl epigallocatechin gallate potent inhibitor with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00017
-
 epigallocatechin gallate
-
 Sus scrofa
0.004
-
 epigallocatechin gallate
-
 Homo sapiens
0.0048
-
 epigallocatechin gallate
-
 Rattus norvegicus
0.0081
-
 epigallocatechin
-
 Sus scrofa
0.0117
-
 epigallocatechin
-
 Homo sapiens
0.0117
-
 epigallocatechin
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
cytosol
-
 Rattus norvegicus 5829
-
cytosol
-
 Sus scrofa 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 Homo sapiens S-adenosyl-L-homocysteine + 4',4''-di-O-methyl epigallocatechin gallate
-
 ?
S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 4',4''-di-O-methyl epigallocatechin gallate
-
 ?
S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 Sus scrofa S-adenosyl-L-homocysteine + 4',4''-di-O-methyl epigallocatechin gallate
-
 ?
S-adenosyl-L-methionine + 3,4-dihydroxy-L-Phe
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + 3,4-dihydroxy-L-Phe
-
 Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + 3,4-dihydroxy-L-Phe
-
 Sus scrofa S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + epigallocatechin
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + epigallocatechin
-
 Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + epigallocatechin
-
 Sus scrofa S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + epigallocatechin gallate
-
 Homo sapiens S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 ?
S-adenosyl-L-methionine + epigallocatechin gallate
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 ?
S-adenosyl-L-methionine + epigallocatechin gallate
-
 Sus scrofa S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 ?
S-adenosyl-L-methionine + L-Dopa
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + L-Dopa
-
 Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + L-Dopa
-
 Sus scrofa S-adenosyl-L-homocysteine + ?
-
 ?