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Literature summary for 2.1.1.6 extracted from

  • Hursel, R.; Janssens, P.L.; Bouwman, F.G.; Mariman, E.C.; Westerterp-Plantenga, M.S.
    The role of catechol-O-methyl transferase Val(108/158)Met polymorphism (rs4680) in the effect of green tea on resting energy expenditure and fat oxidation: a pilot study (2014), PLoS ONE, 9, e106220.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine subjects carrying the Val/Val genotype of the Val108/158Met polymorphism show increased energy expenditure and fat-oxidation upon ingestion of green tea catechins vs placebo, whereas subjects carrying the Met/Met genotype react similarly to green tea and placebo ingestion. The differences in responses are due to the different responses on PL ingestion, but similar responses to green tea ingestion. The different alleles of the functional COMT Val108/158Met polymorphism appear to play a role in the inter-individual variability for energy expenditure and fat oxidation after green tea treatment Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining