Literature summary for 2.1.1.6 extracted from

Weinert, C.; Wiese, S.; Rawel, H.; Esatbeyoglu, T.; Winterhalter, P.; Homann, T.; Kulling, S.
Methylation of catechins and procyanidins by rat and human catechol-o-methyltransferase: Metabolite profiling and molecular modeling studies (2012), Drug Metab. Dispos., 40, 353-359.

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-
cytosol	-	Rattus norvegicus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-
placenta	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
(+)-catechin + S-adenosyl-L-methionine	-	Homo sapiens	S-adenosyl-L-homocysteine + ?	3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1	?
(+)-catechin + S-adenosyl-L-methionine	-	Rattus norvegicus	S-adenosyl-L-homocysteine + ?	3'-O-methyl derivatives are consistently the main metabolites, 3'-O-methyl derivatives are consistently the main metabolites, meta/para ratio of the metabolites is approximately 25:1	?
(-)-epicatechin + S-adenosyl-L-methionine	-	Homo sapiens	S-adenosyl-L-homocysteine + ?	3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1	?
(-)-epicatechin + S-adenosyl-L-methionine	-	Rattus norvegicus	S-adenosyl-L-homocysteine + ?	3'-O-methyl derivatives are consistently the main metabolites, the meta/para ratio of the metabolites is approximately 6:1	?
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine	-	Homo sapiens	4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine	the meta/para ratio of the metabolites is approximately 4.5	?
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine	-	Rattus norvegicus	4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine	the meta/para ratio of the metabolites is approximately 4.5	?
additional information	degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule	Homo sapiens	?	-	?
additional information	degree and position of methylation depend clearly on the three-dimensional structure of the entire substrate molecule	Rattus norvegicus	?	-	?
procyanidin dimer B1 + S-adenosyl-L-methionine	-	Homo sapiens	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin dimer B1 + S-adenosyl-L-methionine	-	Rattus norvegicus	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin dimer B2 + S-adenosyl-L-methionine	-	Homo sapiens	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin dimer B2 + S-adenosyl-L-methionine	-	Rattus norvegicus	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin dimer B3 + S-adenosyl-L-methionine	-	Homo sapiens	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin dimer B3 + S-adenosyl-L-methionine	-	Rattus norvegicus	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin dimer B4 + S-adenosyl-L-methionine	-	Homo sapiens	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin dimer B4 + S-adenosyl-L-methionine	-	Rattus norvegicus	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin dimer B5 + S-adenosyl-L-methionine	-	Homo sapiens	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin dimer B5 + S-adenosyl-L-methionine	-	Rattus norvegicus	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin dimer B7 + S-adenosyl-L-methionine	-	Homo sapiens	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin dimer B7 + S-adenosyl-L-methionine	-	Rattus norvegicus	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated and dimethylated dimeric metabolites	?
procyanidin trimer C1 + S-adenosyl-L-methionine	-	Homo sapiens	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites	?
procyanidin trimer C1 + S-adenosyl-L-methionine	-	Rattus norvegicus	S-adenosyl-L-homocysteine + ?	flavanyl units of procyanidins are methylated consecutively, leading to monomethylated, dimethylated, and trimethylated C1 metabolites	?