Application | Comment | Organism |
---|---|---|
medicine | therapeutic potential of manipulating COMT activity to alter dopaminergic neurotransmission in the prefrontal cortex | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | significant contribution of COMT in modulating the dynamics of dopamine overflow in the prefrontal cortex. Evoked dopamine overflow shows that removal of dopamine is twofold slower in the prefrontal cortex of mice lacking COMT than in wild-type mice, indicating that half of the dopamine decline in this brain region results from COMT-mediated enzymatic degradation. Lack of COMT does not influence dopamine overflow/decline in the dorsal striatum | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
COMT | - |
Mus musculus |