Crystallization (Comment) | Organism |
---|---|
struktures of soluble isoforms in complex with inhibitors, S-adenosyl-L-methionine and Mg2+ | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-butylphenyl)-5-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one | - |
Homo sapiens | |
1-([1,1'-biphenyl]-3-yl)-3-hydroxypyridin-4(1H)-one | - |
Homo sapiens | |
1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-(1-hydroxy-2-methylpropyl)pyridin-4(1H)-one | - |
Homo sapiens | |
1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-(1-hydroxybutyl)pyridin-4(1H)-one | - |
Homo sapiens | |
1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-(1-hydroxyethyl)pyridin-4(1H)-one | - |
Homo sapiens | |
1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one | - |
Homo sapiens | |
1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-methylpyridin-4(1H)-one | - |
Homo sapiens | |
1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-phenylpyridin-4(1H)-one | - |
Homo sapiens | |
1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-[hydroxy(phenyl)methyl]pyridin-4(1H)-one | - |
Homo sapiens | |
1-([1,1'-biphenyl]-4-yl)-5-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one | - |
Homo sapiens | |
5-hydroxy-2-(thiophen-2-yl)pyrimidin-4(1H)-one | - |
Homo sapiens | |
9-hydroxypyrido[2,1-c][1,4]benzothiazin-8(6H)-one | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21964 | - |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000047 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-3-hydroxypyridin-4(1H)-one | |
0.000053 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-methylpyridin-4(1H)-one | |
0.000088 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-[hydroxy(phenyl)methyl]pyridin-4(1H)-one | |
0.000099 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-(1-hydroxyethyl)pyridin-4(1H)-one | |
0.00014 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one | |
0.00014 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-4-yl)-5-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one | |
0.00016 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-(4-butylphenyl)-5-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one | |
0.00018 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-(1-hydroxy-2-methylpropyl)pyridin-4(1H)-one | |
0.0004 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 9-hydroxypyrido[2,1-c][1,4]benzothiazin-8(6H)-one | |
0.00057 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-(1-hydroxybutyl)pyridin-4(1H)-one | |
0.00086 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-hydroxy-2-(thiophen-2-yl)pyrimidin-4(1H)-one | |
0.00087 | - |
membrane-bound isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-phenylpyridin-4(1H)-one | |
0.001 | - |
soluble isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-(1-hydroxybutyl)pyridin-4(1H)-one | |
0.0011 | - |
soluble isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-3-hydroxypyridin-4(1H)-one | |
0.0013 | - |
soluble isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-[hydroxy(phenyl)methyl]pyridin-4(1H)-one | |
0.0014 | - |
soluble isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-(1-hydroxyethyl)pyridin-4(1H)-one | |
0.0019 | - |
soluble isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-(1-hydroxy-2-methylpropyl)pyridin-4(1H)-one | |
0.0021 | - |
soluble isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-methylpyridin-4(1H)-one | |
0.0025 | - |
soluble isoform, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-([1,1'-biphenyl]-3-yl)-5-hydroxy-2-phenylpyridin-4(1H)-one |