Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lactoferrin | bovine lactoferrin binds to and inhibits COMT using its N-terminal region. A fragment of the lactoferrin N-terminal residues 6-50, with two pairs of disulfide bonds, shows higher inhibitory activity than intact lactoferrin. Lactoferrin does not compete with S-adenosylmethionine. COMT activity in the cell extracts form Caco-2 and HepG2 cells is inhibited by lactoferrin and the N-terminal fragment | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21964 | - |
- |