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Literature summary for 2.1.1.6 extracted from

  • Ho, P.W.; Chu, A.C.; Kwok, K.H.; Liu, H.F.; Kung, M.H.; Ramsden, D.B.; Ho, S.L.
    Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells (2008), Curr. Drug Metab., 9, 276-279.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
4-(tert-octyl)phenol causes significant inhibition of enzyme activity Homo sapiens
benzyl butyl phthalate causes significant inhibition of enzyme activity Homo sapiens
dibutyl phthalate causes significant inhibition of enzyme activity Homo sapiens
diisononyl phthalate causes significant inhibition of enzyme activity Homo sapiens
dioctyl phthalate causes significant inhibition of enzyme activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
COMT
-
 Homo sapiens
S-COMT
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 4-(tert-octyl)phenol, benzyl butyl phthalate, diisononyl phthalate, dibutyl phthalate, and dioctyl phthalate inhibit S-COMT protein expression in MCF-7 cells at 72 h, the inhibitory effect is abolished in the presence of the anti-estrogen ICI182780 down