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Literature summary for 2.1.1.6 extracted from

  • Wentz, M.J.; Shi, S.Q.; Shi, L.; Salama, S.A.; Harirah, H.M.; Fouad, H.; Garfield, R.E.; Al-Hendy, A.
    Treatment with an inhibitor of catechol-O-methyltransferase activity reduces preterm birth and impedes cervical resistance to stretch in pregnant rats (2007), Reproduction, 134, 831-839.
    View publication on PubMed
Search for more literature for 2.1.1.6

Inhibitors

Inhibitors Comment Organism Structure
Ro 41-0960
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
myometrium levels of staining for the COMT protein in myometrium are highest on day 1 and lowest on days 8 and 13, but high levels returned by days 16 and 19 of pregnancy. Modulation of COMT activity may play a role in the regulation of myometrial contractility and cervical ripening during pregnancy Rattus norvegicus
-
myometrium modulation of COMT activity may play a role in the regulation of myometrial contractility and cervical ripening during pregnancy Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxyestrogen + S-adenosyl-L-methionine
-
 Rattus norvegicus 2-methoxyestrogen + S-adenosyl-L-homocysteine
-
 ?
4-hydroxyestrogen + S-adenosyl-L-methionine
-
 Rattus norvegicus 4-methoxyestrogen + S-adenosyl-L-homocysteine
-
 ?

Synonyms

Synonyms Comment Organism
catechol-O-methyltransferase
-
 Rattus norvegicus
COMT
-
 Rattus norvegicus