EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
2.1.1.6 | 0.000005 |
0.000042 |
Ro 41-0960 |
IC50: 5-42 nM |
660548 |
2.1.1.6 | 0.000006 |
- |
6-methyl-9-[(5E)-5,6,7-trideoxy-7-[5-(4-fluorophenyl)-2,3-dihydroxybenzamido]-beta-D-ribo-hept-5-enofuranosyl]purine |
liver homogenate, substrate benzene-1,2-diol, pH 7.6, 37°C |
719299 |
2.1.1.6 | 0.0000067 |
- |
tolcapone |
isoform MB-COMT, pH 7.4, 37°C |
732991 |
2.1.1.6 | 0.000009 |
- |
N-[(2E)-3-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]prop-2-en-1-yl]-2,3-dihydroxy-5-nitrobenzamide |
liver homogenate, substrate benzene-1,2-diol, pH 7.6, 37°C |
718479, 719299 |
2.1.1.6 | 0.000009 |
- |
N-[(E)-4-[(2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-but-2-enyl]-2,3-dihydroxy-5-nitro-benzamide |
IC50: 9 nM |
660047 |
2.1.1.6 | 0.000011 |
- |
9-[(5E)-3,5,6,7-tetradeoxy-3-fluoro-7-[5-(4-fluorophenyl)-2,3-dihydroxybenzamido]-beta-D-xylo-hept-5-enofuranosyl]-N6-methyladenine |
liver homogenate, substrate benzene-1,2-diol, pH 7.6, 37°C |
718479 |
2.1.1.6 | 0.000011 |
- |
N-[(2E)-3-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)-9H-purin-9-yl]tetrahydrofuran-2-yl]prop-2-en-1-yl]-4'-fluoro-4,5-dihydroxybiphenyl-3-carboxamide |
liver homogenate, substrate benzene-1,2-diol, pH 7.6, 37°C |
718479 |
2.1.1.6 | 0.000013 |
- |
5-hydroxy-1-[3-(isoquinolin-4-yl)phenyl]-2-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-4(1H)-one |
isoform MB-COMT, pH 7.4, 37°C |
732991 |
2.1.1.6 | 0.000025 |
- |
9-[(5E)-3,5,6,7-tetradeoxy-7-[5-(4-fluorophenyl)-2,3-dihydroxybenzamido]-3-methyl-beta-D-xylo-hept-5-enofuranosyl]-N6-propyladenine |
liver homogenate, substrate benzene-1,2-diol, pH 7.6, 37°C |
718479 |
2.1.1.6 | 0.000026 |
- |
N-[(2E)-3-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(propylamino)-9H-purin-9-yl]tetrahydrofuran-2-yl]prop-2-en-1-yl]-4'-fluoro-4,5-dihydroxybiphenyl-3-carboxamide |
liver homogenate, substrate benzene-1,2-diol, pH 7.6, 37°C |
718479 |