Information on EC 3.1.3.1 - alkaline phosphatase

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The expected taxonomic range for this enzyme is: Archaea, Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
3.1.3.1
-
RECOMMENDED NAME
GeneOntology No.
alkaline phosphatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a phosphate monoester + H2O = an alcohol + phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
phosphomonoester
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Aminobenzoate degradation
-
-
diethylphosphate degradation
-
-
Folate biosynthesis
-
-
Metabolic pathways
-
-
Microbial metabolism in diverse environments
-
-
NAD phosphorylation and dephosphorylation
-
-
NAD salvage pathway III
-
-
NAD/NADH phosphorylation and dephosphorylation
-
-
sulfopterin metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
phosphate-monoester phosphohydrolase (alkaline optimum)
Wide specificity. Also catalyses transphosphorylations. The human placental enzyme is a zinc protein. Some enzymes hydrolyse diphosphate (cf. EC 3.6.1.1 inorganic diphosphatase)
CAS REGISTRY NUMBER
COMMENTARY hide
9001-78-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain K1
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
antarctic bacterium
antarctic bacterium HK47
strain HK47
-
-
Manually annotated by BRENDA team
three isoenzymes: I, II, III
-
-
Manually annotated by BRENDA team
alkaline phosphatase F I; alkaline phosphatase F II
-
-
Manually annotated by BRENDA team
strain MC14
-
-
Manually annotated by BRENDA team
strain P9
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain P9
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
strain J2315
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
A3ZF85
UniProt
Manually annotated by BRENDA team
CBS 6947
-
-
Manually annotated by BRENDA team
CBS 6947
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Cobetia marina KMM MC-296
strain KMM MC-296
-
-
Manually annotated by BRENDA team
Syrian hamster
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
gene alp
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain C4F1
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain KP1
-
-
Manually annotated by BRENDA team
strain KP1
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Micrococcus sodonensis
-
-
-
Manually annotated by BRENDA team
Mus musculus C57BL/6-N
C57BL/6-N mice
-
-
Manually annotated by BRENDA team
levamisole-insensitive alkaline phosphatase activity; levamisole-sensitive alkaline phosphatase activity
-
-
Manually annotated by BRENDA team
Neurospora crassa St. L. 74A
strain St. L. 74A, constitutive enzyme expression
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
no activity in Marinovum algicola
-
-
-
Manually annotated by BRENDA team
no activity in Marinovum algicola ATCC 51442
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Ophicephalus punctatus Bloch
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain X-73
UniProt
Manually annotated by BRENDA team
strain X-73
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain 381
-
-
Manually annotated by BRENDA team
strain 381
-
-
Manually annotated by BRENDA team
ATCC 25611
-
-
Manually annotated by BRENDA team
H103
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain 257
-
-
Manually annotated by BRENDA team
Saccharomyces pombe
substrate specific enzyme form from structural gene PHO2, non specific enzyme form from structural gene PHO3 and particulate enzyme form from structural gene PHO3
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
clam, Da Costa 1778
-
-
Manually annotated by BRENDA team
thermostable conidial and mycelial alkaline phosphatases, thermophilic fungus
-
-
Manually annotated by BRENDA team
strain 211, 2 distinct enzyme forms, an inducible enzyme form IAPase in 4 isozymes, and a constitutive enzyme form CAPase
-
-
Manually annotated by BRENDA team
strain 211, 2 distinct enzyme forms, an inducible enzyme form IAPase in 4 isozymes, and a constitutive enzyme form CAPase
-
-
Manually annotated by BRENDA team
SIB1
-
-
Manually annotated by BRENDA team
SIB1
-
-
Manually annotated by BRENDA team
shrimp
cold-adapted enzyme
-
-
Manually annotated by BRENDA team
strain R2
-
-
Manually annotated by BRENDA team
Chatin
-
-
Manually annotated by BRENDA team
Chatin
-
-
Manually annotated by BRENDA team
strain 314
-
-
Manually annotated by BRENDA team
strain T351
SwissProt
Manually annotated by BRENDA team
strain XM
SwissProt
Manually annotated by BRENDA team
strain XM
SwissProt
Manually annotated by BRENDA team
sp. nov.
-
-
Manually annotated by BRENDA team
Kjelm
-
-
Manually annotated by BRENDA team
Kjelm
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Vibrio 2P44
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
venomous snake
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2',3'-CMP + H2O
?
show the reaction diagram
-
-
-
-
?
2',3'-GMP + H2O
?
show the reaction diagram
2',3'-UMP + H2O
?
show the reaction diagram
-
-
-
-
?
2',3-AMP + H2O
?
show the reaction diagram
2'-AMP + H2O
adenosine + phosphate
show the reaction diagram
2'-CMP + H2O
cytidine + phosphate
show the reaction diagram
-
-
-
-
?
2'-deoxyadenosine 5'-monophosphate + H2O
?
show the reaction diagram
2'-GMP + H2O
guanosine + phosphate
show the reaction diagram
-
-
-
-
?
2'-UMP + H2O
uridine + phosphate
show the reaction diagram
-
-
-
-
?
2'-[2-benzthiazole]-6'-hydroxybenzthiazole phosphate + H2O
2'-[2-benzthiazole]-6'-hydroxybenzthiazole + phosphate
show the reaction diagram
-
weakly fluorescent substrate
highly fluorescent product
?
2,4-dinitrophenyl phosphate + H2O
2,4-dinitrophenol + phosphate
show the reaction diagram
-
-
-
-
?
2-chloro-5-(4-methoxyspiro (1,2-dioxetane-3,2'-(5'-chloro)tricyclo[3.3.1.13,7]decan)-4-yl)phenyl phosphate + H2O
2-chloro-5-(4-methoxyspiro (1,2-dioxetane-3,2'-(5'-chloro)tricyclo[3.3.1.13,7]decan)-4-yl)phenol + phosphate
show the reaction diagram
-
CDP-star
-
-
?
2-glycerol phosphate + H2O
glycerol + phosphate
show the reaction diagram
-
-
-
?
2-naphthyl phosphate + H2O
2-naphthol + phosphate
show the reaction diagram
2-naphtyl phosphate + H2O
2-napthol + phosphate
show the reaction diagram
-
-
-
-
?
2-phosphoglycerate + H2O
glycerol + phosphate
show the reaction diagram
3'-ADP + H2O
?
show the reaction diagram
-
-
-
-
?
3'-AMP + H2O
adenosine + phosphate
show the reaction diagram
3'-CMP + H2O
cytidine + phosphate
show the reaction diagram
-
-
-
-
?
3'-GMP + H2O
guanosine + phosphate
show the reaction diagram
-
-
-
-
?
3'-ITP + H2O
?
show the reaction diagram
-
51.5% of the activity with 4-nitrophenyl phosphate
-
-
?
3'-UMP + H2O
uridine + phosphate
show the reaction diagram
-
-
-
-
?
3-nitrobenzyl phosphate + H2O
3-nitrobenzoate + phosphate
show the reaction diagram
-
-
-
-
?
3-phosphoglycerate + H2O
glycerol + phosphate
show the reaction diagram
4-methylumbelliferyl phosphate + H2O
4-methylumbelliferone + phosphate
show the reaction diagram
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
4-nitrophenyl sulfate + H2O
4-nitrophenol + sulfate
show the reaction diagram
-
-
-
-
?
5'-ADP + H2O
?
show the reaction diagram
5'-AMP + H2O
adenosine + phosphate
show the reaction diagram
5'-ATP + H2O
?
show the reaction diagram
5'-CMP + H2O
cytidine + phosphate
show the reaction diagram
5'-dAMP + H2O
?
show the reaction diagram
-
-
-
-
?
5'-dCMP + H2O
?
show the reaction diagram
5'-dCMP + H2O
deoxycytidine + phosphate
show the reaction diagram
-
80% of activity with p-nitrophenyl phosphate
-
-
?
5'-dGMP + H2O
?
show the reaction diagram
-
-
-
-
?
5'-dTMP + H2O
?
show the reaction diagram
5'-GMP + H2O
guanosine + phosphate
show the reaction diagram
5'-IMP + H2O
inosine + phosphate
show the reaction diagram
5'-TMP + H2O
thymidine + phosphate
show the reaction diagram
-
-
-
-
?
5'-UMP + H2O
uridine + phosphate
show the reaction diagram
5-bromo-4-chloro-3-indolyl phosphate + H2O
?
show the reaction diagram
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
?
show the reaction diagram
-
-
-
-
-
acyl-CoA:cholesterol acyltransferase + H2O
?
show the reaction diagram
-
-
-
-
?
adenosine 5'-(beta-glucosyl)diphosphate + H2O
?
show the reaction diagram
-
29.8% of the activity with 4-nitrophenyl phosphate
-
-
?
adenosine 5'-diphosphate + H2O
AMP + phosphate
show the reaction diagram
-
77% of the activity with 4-nitrophenyl phosphate
-
-
?
adenosine 5'-monophosphate + H2O
?
show the reaction diagram
306.1% of the activity with 4-nitrophenyl phosphate
-
-
?
adenosine 5'-triphosphate + H2O
?
show the reaction diagram
257.4% of the activity with 4-nitrophenyl phosphate
-
-
?
adenosine 5'-triphosphate + H2O
AMP + phosphate
show the reaction diagram
-
61% of the activity with 4-nitrophenyl phosphate
-
-
?
ADP + H2O
?
show the reaction diagram
ADP + H2O
AMP + phosphate
show the reaction diagram
alpha-glycerophosphate + H2O
glycerol + phosphate
show the reaction diagram
-
60% of activity with p-nitrophenyl phosphate
-
-
?
alpha-naphthyl acid phosphate + H2O
?
show the reaction diagram
88.6% of the activity with 4-nitrophenyl phosphate
-
-
?
alpha-naphthyl phosphate + H2O
alpha-naphthol + phosphate
show the reaction diagram
alpha-naphthyl phosphate + H2O
naphthol + phosphate
show the reaction diagram
alpha/beta-glycerophosphate + H2O
glycerol + phosphate
show the reaction diagram
-
low activity with alpha-isomer
-
?
AMP + H2O
adenosine + phosphate
show the reaction diagram
arginine phosphate + H2O
Arg + phosphate
show the reaction diagram
-
-
-
-
?
ATP + H2O
?
show the reaction diagram
ATP + H2O
ADP + phosphate
show the reaction diagram
beta-glycerol phosphate + H2O
glycerol + phosphate
show the reaction diagram
-
-
-
?
beta-glycerophosphate + H2O
?
show the reaction diagram
-
-
-
-
?
beta-glycerophosphate + H2O
glycerol + phosphate
show the reaction diagram
beta-glyceryl phosphate + H2O
glycerol + phosphate
show the reaction diagram
bis(p-nitrophenyl) phosphate + H2O
?
show the reaction diagram
bis(p-nitrophenyl)phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
bis-4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
-
-
-
-
?
bis-p-nitrophenyl phosphate + H2O
?
show the reaction diagram
bromochloroindolyl phosphate + nitroblue tetrazolium
?
show the reaction diagram
-
i.e. BCIP/NBT system
-
?
cAMP + H2O
?
show the reaction diagram
-
-
-
?
casein + H2O
?
show the reaction diagram
CMP + H2O
cytidine + phosphate
show the reaction diagram
cysteamine S-phosphate + H2O
cysteamine + phosphate
show the reaction diagram
-
-
-
-
?
cytidine 5'-monophosphate + H2O
?
show the reaction diagram
343.8% of the activity with 4-nitrophenyl phosphate
-
-
?
cytidine phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
D-fructose 1,6-diphosphate + H2O
?
show the reaction diagram
-
52% of the activity with 4-nitrophenyl phosphate
-
-
?
D-fructose 6-phosphate + H2O
D-fructose + phosphate
show the reaction diagram
D-glucose 1-phosphate + H2O
D-glucose + phosphate
show the reaction diagram
D-glucose 6-phosphate + H2O
D-glucose + phosphate
show the reaction diagram
D-ribose 5-phosphate + H2O
D-ribose + phosphate
show the reaction diagram
dAMP + H2O
?
show the reaction diagram
-
-
-
-
?
dATP + H2O
?
show the reaction diagram
-
-
-
-
?
dCMP + H2O
?
show the reaction diagram
-
-
-
-
?
dCTP + H2O
?
show the reaction diagram
-
-
-
-
?
dentine phosphoprotein + H2O
?
show the reaction diagram
-
-
-
-
?
dGMP + H2O
?
show the reaction diagram
-
-
-
-
?
dGTP + H2O
?
show the reaction diagram
-
-
-
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
disodium 3-(4-meth- oxyspiro [1,2-dioxetane-3,2'-(5'-chloro)-tricyclo [3.3.1.13,7]- decan]-4-yl)phenyl phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
dTTP + H2O
?
show the reaction diagram
-
-
-
-
?
ethyl phosphate + H2O
ethanol + phosphate
show the reaction diagram
-
-
-
-
?
etoposide phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
fructose 1,6-diphosphate + H2O
?
show the reaction diagram
gamma-glycerophosphate + H2O
glycerol + phosphate
show the reaction diagram
-
-
-
?
glucose 1-phosphate + H2O
glucose + phosphate
show the reaction diagram
Glucose 6-phosphate + H2O
Glucose + phosphate
show the reaction diagram
glycerophosphate + H2O
?
show the reaction diagram
glycerophosphate + H2O
glycerol + phosphate
show the reaction diagram
glycogen synthase + H2O
?
show the reaction diagram
GMP + H2O
guanosine + phosphate
show the reaction diagram
GTP + H2O
?
show the reaction diagram
guanosine 5'-monophosphate + H2O
?
show the reaction diagram
358.8% of the activity with 4-nitrophenyl phosphate
-
-
?
guanosine phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
histidinol phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
histone + H2O
?
show the reaction diagram
-
32P-labelled
-
-
?
histone II-A + H2O
?
show the reaction diagram
-
enzyme shows protein phosphatase activity
-
?
HMG-CoA reductase + H2O
?
show the reaction diagram
-
-
-
-
?
indoxyl phosphate + nitroblue tetrazolium chloride
nitrioblue diformazan + phosphate
show the reaction diagram
-
-
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
show the reaction diagram
-
-
-
-
?
L-histidinyl phosphate + H2O
L-histidinol + phosphate
show the reaction diagram
methyl 4-nitrophenyl phosphate + H2O
methyl phosphate + 4-nitrophenol
show the reaction diagram
-
-
-
-
?
methyl 4-nitrophenyl phosphorothioate + H2O
4-nitrophenol + methyl phosphorothioate
show the reaction diagram
-
only the R-enantiomer is detectably hydrolyzed by the enzyme
-
-
?
methyl p-nitrophenyl phosphate + H2O
methanol + p-nitrophenol + phosphate
show the reaction diagram
-
-
-
-
?
methyl p-nitrophenyl phosphorothioate + H2O
methanol + p-nitrophenol + phosphorothioate
show the reaction diagram
-
-
-
-
?
methyl phosphate + H2O
methanol + phosphate
show the reaction diagram
-
-
-
-
?
N-acetylcysteamine S-phosphate + H2O
N-acetylcysteamine + phosphate
show the reaction diagram
-
-
-
-
?
NAD+ + H2O
?
show the reaction diagram
NADP+ + H2O
?
show the reaction diagram
-
20% of activity with p-nitrophenyl phosphate
-
-
?
NADPH-cytochrome reductase + H2O
?
show the reaction diagram
-
-
-
-
?
o-carboxyphenyl phosphate + H2O
o-carboxyphenol + phosphate
show the reaction diagram
-
-
-
-
?
O-phospho-DL-serine + H2O
DL-serine + phosphate
show the reaction diagram
-
-
-
?
O-phospho-DL-tyrosine + H2O
DL-tyrosine + phosphate
show the reaction diagram
-
-
-
?
O-phosphoserine + H2O
serine + phosphate
show the reaction diagram
O-phosphothreonine + H2O
threonine + phosphate
show the reaction diagram
O-phosphotyrosine + H2O
tyrosine + phosphate
show the reaction diagram
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
p-nitrophenyl sulfate + H2O
p-nitrophenol + sulfate
show the reaction diagram
p-toluidinium 5-bromo-4-chloro-3-indolyl phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
paraoxon + H2O
?
show the reaction diagram
-
-
-
-
?
phenyl phosphate + H2O
phenol + phosphate
show the reaction diagram
phospho-DL-Thr + H2O
phosphate + Thr
show the reaction diagram
-
-
-
-
?
phospho-DL-Tyr + H2O
phosphate + Tyr
show the reaction diagram
-
-
-
-
?
phospho-Ser histone + H2O
?
show the reaction diagram
phospho-Ser-casein + H2O
?
show the reaction diagram
phospho-Tyr angiotensin + H2O
angiotensin + phosphate
show the reaction diagram
-
-
-
-
?
phospho-Tyr-casein + H2O
?
show the reaction diagram
-
-
-
-
?
phospho-Tyr-histone + H2O
?
show the reaction diagram
phosphocholine + H2O
choline + phosphate
show the reaction diagram
-
-
-
-
?
phosphoenolpyruvate + H2O
pyruvate + phosphate
show the reaction diagram
phosphoethanolamine + H2O
phosphate + ethanolamine
show the reaction diagram
phosphorylase kinase + H2O
?
show the reaction diagram
phosphorylated acetyl-CoA carboxylase + H2O
acetyl-CoA carboxylase + phosphate
show the reaction diagram
phosphorylcholine + H2O
phosphate + choline
show the reaction diagram
phosphoserine + H2O
phosphate + Ser
show the reaction diagram
phosphothreonine + H2O
phosphate + Thr
show the reaction diagram
-
22.1% of the activity with 4-nitrophenyl phosphate
-
-
?
phosphotyrosine + H2O
phosphate + Tyr
show the reaction diagram
-
23.7% of the activity with 4-nitrophenyl phosphate
-
-
?
phosvitin + H2O
?
show the reaction diagram
poly(I) + H2O
?
show the reaction diagram
-
-
-
-
?
polyC + H2O
?
show the reaction diagram
-
-
-
-
?
polymetaphosphate + H2O
?
show the reaction diagram
-
-
-
-
?
polyphosphate PP-25 + H2O
?
show the reaction diagram
-
-
-
-
?
protamine + H2O
?
show the reaction diagram
-
-
-
-
?
pyridoxal 5'-phosphate + H2O
?
show the reaction diagram
pyridoxal 5'-phosphate + H2O
pyridoxal + phosphate
show the reaction diagram
-
-
-
?
Raytide + H2O
?
show the reaction diagram
-
-
-
-
?
riboflavin 5'-phosphate + H2O
riboflavin + phosphate
show the reaction diagram
-
-
-
-
?
S-(carboxymethyl)phosphorothioate + H2O
?
show the reaction diagram
-
-
-
-
?
S-[2-(methoxy carbonyl)ethyl] phosphorothioate + H2O
?
show the reaction diagram
-
-
-
-
?
spermidine N'-acetyltransferase + H2O
?
show the reaction diagram
-
-
-
-
?
thiamin diphosphate + H2O
thiamin phosphate + phosphate
show the reaction diagram
-
-
-
-
?
trehalose 6-phosphate + H2O
trehalose + phosphate
show the reaction diagram
-
-
-
-
?
triphosphate + H2O
diphosphate + phosphate
show the reaction diagram
tyrosine phosphate + H2O
tyrosine + phosphate
show the reaction diagram
-
-
-
-
?
UDP + H2O
?
show the reaction diagram
UDP-glucose + H2O
?
show the reaction diagram
-
20% of activity with p-nitrophenyl phosphate
-
-
?
UMP + H2O
uridine + phosphate
show the reaction diagram
uridine 5'-monophosphate + H2O
?
show the reaction diagram
388.6% of the activity with 4-nitrophenyl phosphate
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uridine phosphate + H2O
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show the reaction diagram
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UTP + H2O
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show the reaction diagram
additional information
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