Literature summary for 3.1.3.1 extracted from

Iida, M.; Ihara, S.; Matsuzaki, T.
Hair cycle-dependent changes of alkaline phosphatase activity in the mesenchyme and epithelium in mouse vibrissal follicles (2007), Dev. Growth Differ., 49, 185-195.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57BL/6-N mice	-
Mus musculus C57BL/6N	-	C57BL/6-N mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
vibrissal follicle	restricted mesenchymal and epithelial regions. Its localization and strength changes during the hair cycle. Activity in the dermal papilla is moderate in very early anagen, reaches a maximal level in early anagen, decreases at the proximal region of dermal papilla after mid anagen, and is kept at a low level during catagen. The bulbar dermal sheath shows intense alkaline phosphatase activity only in early anagen. Most bulbar epithelium does not show alkaline phosphatase activity, germinative epidermal cells that are adjacent to the alkaline phosphatase-negative dermal papilla cells become alkaline phosphatase-positive in mid anagen and rearrange in a single layer so as to encapsulate the dermal papilla in mid catagen. During catagen, the outermost layer of bulbar epithelium becomes alkaline phosphatase-positive, which could be follicular epithelial precursors migrating from the bulge. Before the initiation of hair formation, alkaline phosphatase activity in the bulbar epithelium rapidly decreases and that in dermal papilla increases. These dynamic changes of alkaline phosphatase expression might be related to functions of the dermal papilla in hair induction and also to reconstruction of the bulbar structure during the hair cycle	Mus musculus	-

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Release 2023.1 (January 2023)