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Literature summary for 3.1.3.1 extracted from

  • Price, P.A.; Toroian, D.; Chan, W.S.
    Tissue-nonspecific Alkaline Phosphatase Is Required for the Calcification of Collagen in Serum: A possible mechanism for biomineralization (2009), J. Biol. Chem., 284, 4594-4604.
    View publication on PubMed
Search for more literature for 3.1.3.1

Application

Application Comment Organism
medicine TNAP is an essential component of serum calcification activity and that its role in the shotgun mechanism is to activate the serum nucleator of apatite crystal formation Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 1 mM, irreversibly inactivates the enzyme Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus TNAP is an essential component of serum calcification activity and that its role in the shotgun mechanism is to activate the serum nucleator of apatite crystal formation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
 Bos taurus 4-nitrophenol + phosphate
-
 ?
additional information TNAP is an essential component of serum calcification activity and that its role in the shotgun mechanism is to activate the serum nucleator of apatite crystal formation Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
alkaline phosphatase
-
 Bos taurus
TNAP
-
 Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10.4
-
 assay at Bos taurus