Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.1 extracted from

  • Sidique, S.; Ardecky, R.; Su, Y.; Narisawa, S.; Brown, B.; Millan, J.L.; Sergienko, E.; Cosford, N.D.
    Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) (2009), Bioorg. Med. Chem. Lett., 19, 222-225.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1-[[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]carbonyl]-4-ethylpiperazine
-
Bos taurus
1-[[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]carbonyl]-4-methylpiperazine
-
Bos taurus
1-[[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]carbonyl]azepane
-
Bos taurus
2-(4-[[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]carbonyl]piperazin-1-yl)ethanol
-
Bos taurus
3-(2,4-dichloro-5-fluorophenyl)-N,N-bis(2-hydroxyethyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichloro-5-fluorophenyl)-N,N-dimethyl-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichloro-5-fluorophenyl)-N-(1-methylethyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichloro-5-fluorophenyl)-N-(2-hydroxyethyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichloro-5-fluorophenyl)-N-(3-hydroxypropyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichlorophenyl)-1H-pyrazole-5-carbohydrazide
-
Bos taurus
3-(2,4-dichlorophenyl)-N,N-bis(2-hydroxyethyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichlorophenyl)-N,N-diethyl-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichlorophenyl)-N,N-dimethyl-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichlorophenyl)-N-(1-methylethyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichlorophenyl)-N-(2-hydroxyethyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichlorophenyl)-N-(2-methoxyethyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichlorophenyl)-N-(2-methylpropyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichlorophenyl)-N-(3-hydroxypropyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichlorophenyl)-N-(3-methylbutyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-dichlorophenyl)-N-(4-hydroxybutyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
3-(2,4-difluorophenyl)-N-(2-hydroxyethyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
4-[[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]carbonyl]morpholine
-
Bos taurus
N-(2-hydroxyethyl)-3-(2,3,4-trichlorophenyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
N-(2-hydroxyethyl)-3-(2,4,5-trifluorophenyl)-1H-pyrazole-5-carboxamide
-
Bos taurus
N-tert-butyl-3-(2,4-dichlorophenyl)-1H-pyrazole-5-carboxamide
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus P09487
-
-

Synonyms

Synonyms Comment Organism
tissue-nonspecific alkaline phosphatase
-
Bos taurus
TNAP
-
Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000005
-
-
Bos taurus N-(2-hydroxyethyl)-3-(2,3,4-trichlorophenyl)-1H-pyrazole-5-carboxamide
0.000031
-
-
Bos taurus 3-(2,4-dichlorophenyl)-N-(3-hydroxypropyl)-1H-pyrazole-5-carboxamide
0.000035
-
-
Bos taurus 3-(2,4-dichlorophenyl)-N-(4-hydroxybutyl)-1H-pyrazole-5-carboxamide
0.000035
-
-
Bos taurus 3-(2,4-difluorophenyl)-N-(2-hydroxyethyl)-1H-pyrazole-5-carboxamide
0.000044
-
-
Bos taurus 3-(2,4-dichlorophenyl)-1H-pyrazole-5-carbohydrazide
0.000044
-
-
Bos taurus 3-(2,4-dichlorophenyl)-N-(2-hydroxyethyl)-1H-pyrazole-5-carboxamide
0.000046
-
-
Bos taurus 3-(2,4-dichlorophenyl)-N-(2-methoxyethyl)-1H-pyrazole-5-carboxamide
0.000047
-
-
Bos taurus 3-(2,4-dichlorophenyl)-N,N-bis(2-hydroxyethyl)-1H-pyrazole-5-carboxamide
0.000051
-
-
Bos taurus 3-(2,4-dichlorophenyl)-N-(1-methylethyl)-1H-pyrazole-5-carboxamide
0.000056
-
-
Bos taurus 3-(2,4-dichloro-5-fluorophenyl)-N-(3-hydroxypropyl)-1H-pyrazole-5-carboxamide
0.000082
-
-
Bos taurus 3-(2,4-dichlorophenyl)-N-(2-methylpropyl)-1H-pyrazole-5-carboxamide
0.0001
-
-
Bos taurus 3-(2,4-dichloro-5-fluorophenyl)-N-(2-hydroxyethyl)-1H-pyrazole-5-carboxamide
0.000119
-
-
Bos taurus 3-(2,4-dichlorophenyl)-N,N-dimethyl-1H-pyrazole-5-carboxamide
0.000127
-
-
Bos taurus 3-(2,4-dichloro-5-fluorophenyl)-N,N-bis(2-hydroxyethyl)-1H-pyrazole-5-carboxamide
0.000134
-
-
Bos taurus N-(2-hydroxyethyl)-3-(2,4,5-trifluorophenyl)-1H-pyrazole-5-carboxamide
0.000285
-
-
Bos taurus 3-(2,4-dichlorophenyl)-N,N-diethyl-1H-pyrazole-5-carboxamide
0.000324
-
-
Bos taurus 3-(2,4-dichloro-5-fluorophenyl)-N,N-dimethyl-1H-pyrazole-5-carboxamide
0.000375
-
-
Bos taurus 2-(4-[[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]carbonyl]piperazin-1-yl)ethanol
0.000398
-
-
Bos taurus N-tert-butyl-3-(2,4-dichlorophenyl)-1H-pyrazole-5-carboxamide
0.000459
-
-
Bos taurus 3-(2,4-dichlorophenyl)-N-(3-methylbutyl)-1H-pyrazole-5-carboxamide
0.000488
-
-
Bos taurus 1-[[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]carbonyl]-4-ethylpiperazine
0.000574
-
-
Bos taurus 4-[[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]carbonyl]morpholine
0.000828
-
-
Bos taurus 1-[[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]carbonyl]-4-methylpiperazine
0.00145
-
-
Bos taurus 1-[[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]carbonyl]azepane
0.00485
-
-
Bos taurus 3-(2,4-dichloro-5-fluorophenyl)-N-(1-methylethyl)-1H-pyrazole-5-carboxamide