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Literature summary for 3.1.3.1 extracted from

  • Goldstein, D.J.; Harris, H.
    Human placental alkaline phosphatase differs from that of other species (1979), Nature, 280, 602-605.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
liver and milk isoenzymes have similar or perhaps identical peptide structures and may be coded by the same gene Homo sapiens
three gene loci seem to be involved in determining the various forms of alkaline phosphatase, one coding for the placental form, at least one coding for the intestinal forms, and at least one for the liver, bone and kidney forms Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
L-homoarginine marked inhibition of the liver enzyme at concentrations which produce only slight inhibition of placental enzyme Homo sapiens
L-homoarginine
-
Rattus norvegicus
L-Phe-Gly-Gly marked inhibition of the placental enzyme at concentrations which produce only slight inhibition of liver enzyme Homo sapiens
Phe marked inhibition of the placental enzyme at concentrations which produce only slight inhibition of liver enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-
Felis catus
-
-
-
Homo sapiens
-
-
-
Macaca mulatta
-
-
-
Mesocricetus auratus
-
-
-
Mus musculus
-
-
-
Ovis aries
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Cavia porcellus
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-
liver
-
Bos taurus
-
liver
-
Ovis aries
-
liver
-
Canis lupus familiaris
-
liver
-
Mesocricetus auratus
-
liver
-
Felis catus
-
liver
-
Macaca mulatta
-
placenta
-
Cavia porcellus
-
placenta
-
Mus musculus
-
placenta
-
Homo sapiens
-
placenta
-
Rattus norvegicus
-
placenta
-
Sus scrofa
-
placenta
-
Bos taurus
-
placenta
-
Ovis aries
-
placenta
-
Canis lupus familiaris
-
placenta
-
Mesocricetus auratus
-
placenta
-
Felis catus
-
placenta
-
Macaca mulatta
-

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
56
-
placental enzyme is stable, 50% inactivation of the liver enzyme after 8.2 min Homo sapiens
56
-
50% inactivation of the placental enzyme after 4.4 min, 50% inactivation of the liver enzyme after 7.9 min Mesocricetus auratus
56
-
50% inactivation of the placental enzyme after 10.9 min, 50% inactivation of the liver enzyme after 16.0 min Bos taurus
56
-
50% inactivation of the placental enzyme after 8.2 min, 50% inactivation of the liver enzyme after 18.7 min Macaca mulatta
56
-
50% inactivation of the placental enzyme after 23.1 min, 50% inactivation of the liver enzyme after 14.2 min Canis lupus familiaris
56
-
50% inactivation of the placental enzyme after 10.8 min, 50% inactivation of the liver enzyme after 9.0 min Ovis aries
56
-
50% inactivation of the liver and the placental enzyme after 6.6 min Cavia porcellus
56
-
50% inactivation of the placental enzyme after 2.3 min, 50% inactivation of the liver enzyme after 5.8 min Mus musculus
56
-
50% inactivation of the placental enzyme after 12.3 min, 50% inactivation of the liver enzyme after 18.2 min Felis catus
56
-
50% inactivation of the placental enzyme after 9.7 min, 50% inactivation of the liver enzyme after 3.5 min Sus scrofa
56
-
50% inactivation of the placental enzyme after 2.2 min, 50% inactivation of the liver enzyme after 5.0 min Rattus norvegicus
65
-
50% inactivation of the placental enzyme after 0.42 min, 50% inactivation of the liver enzyme after 0.84 min Rattus norvegicus
65
-
50% inactivation of the placental enzyme after 0.21 min, 50% inactivation of the liver enzyme after 0.32 min Mesocricetus auratus
65
-
50% inactivation of the placental enzyme after 0.97 min, 50% inactivation of the liver enzyme after 0.92 min Cavia porcellus
65
-
50% inactivation of the placental enzyme after 1.2 min, 50% inactivation of the liver enzyme after 1.31 min Canis lupus familiaris
65
-
50% inactivation of the placental enzyme after 0.76 min, 50% inactivation of the liver enzyme after 0.45 min Macaca mulatta
65
-
50% inactivation of the placental enzyme after 1.04 min, 50% inactivation of the liver enzyme after 1.32 min Bos taurus
65
-
50% inactivation of the placental enzyme after 0.91 min, 50% inactivation of the liver enzyme after 0.65 min Sus scrofa
65
-
50% inactivation of the placental enzyme after 0.52 min, 50% inactivation of the liver enzyme after 0.35 min Ovis aries
65
-
50% inactivation of the placental enzyme after 0.67 min, 50% inactivation of the liver enzyme after 0.6 min Felis catus
65
-
50% inactivation of the placental enzyme after 0.58 min, 50% inactivation of the liver enzyme after 0.8 min Mus musculus
65
-
placental enzyme is stable, 50% inactivation of the liver enzyme after 1.05 min Homo sapiens