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ATP + H2O
ADP + phosphate
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dynamin also has ATPase activity
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GTP + H2O
GDP + phosphate
additional information
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GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
involved in vesicle scission
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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dynamin self-association is not sufficient condition for the expression of maximal GTPase activity, dynamin molecules must be in proper conformation or orientation if they are to form an active oligomer
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GTP + H2O
GDP + phosphate
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highly specific for GTP
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GTP + H2O
GDP + phosphate
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critical step in fission of coated pits to form coated vesicles
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GTP + H2O
GDP + phosphate
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enzyme is essential for budding clathrin-coated vesicles from the plasma membrane
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GTP + H2O
GDP + phosphate
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plays an essential role in synaptic vesicle recycling
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GTP + H2O
GDP + phosphate
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plays an essential role in synaptic vesicle recycling
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GTP + H2O
GDP + phosphate
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involved in clathrin-mediated endocytosis and other vesicular trafficking processes, dynamin has a mechanochemical function in vesicle scission, the GTPase activity of dynamin and the resulting conformation change are essential for endocytosis
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GTP + H2O
GDP + phosphate
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involved in membrane vesiculation
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GTP + H2O
GDP + phosphate
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GTP hydrolysis results in conformational changes in dynamin bound to lipid nanotubes
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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enzyme plays an important role in the recycling of synaptic vesicles. Different dynamin domains contribute to axonal transport and the sequestration of a pool of dynamin molecules in synaptic cytosol
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GTP + H2O
GDP + phosphate
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the large GTPase dynamin is involved in membrane tubulation and vesiculation, it associates with the spindle midzone and is required for cytokinesis
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GTP + H2O
GDP + phosphate
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DYN-1 mediates the signaling of the CED-1 pathway by organizing an intracellular vesicle pool and promoting vesicle delivery to phagocytic cups and phagosomes to support pseudopod extension and apoptotic cell degradation
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GTP + H2O
GDP + phosphate
involved in vesicle scission
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
involved in vesicle scission
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GTP + H2O
GDP + phosphate
Drosophila sp. (in: flies)
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GTP + H2O
GDP + phosphate
Drosophila sp. (in: flies)
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GTP + H2O
GDP + phosphate
Drosophila sp. (in: flies)
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dynein light chain 1 regulates dynamin-mediated F-actin assembly during sperm individualization in Drosophila
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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657723, 659560, 668369, 669471, 669573, 669581, 670364, 697236, 697237, 700294, 719766 -
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GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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regulates late events in clathrin-coated vescicle formation, GTP hydrolysis is required for vesicle detachment, a concerted conformational change resulting from coordinated GTP hydrolysis by the dynamin oligomer might by sufficient to generate force
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GTP + H2O
GDP + phosphate
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dynamin is a regulatory GTPase in endocytosis of the glucose transporter GLUT4
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GTP + H2O
GDP + phosphate
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critical step in fission of coated pits to form coated vesicles
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GTP + H2O
GDP + phosphate
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plays an essential role in synaptic vesicle recycling
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GTP + H2O
GDP + phosphate
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dynamin 2 can act as a signal transducing GTPase affecting transcriptional regulation
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GTP + H2O
GDP + phosphate
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dynamin plays a role in clathrin-mediated endocytosis, it plays a role in vesicle budding, dynamin is specifically required for endocytic coated vesicle formation and its GTP binding and hydrolysis activities are required to form constricted coated pits and, subsequently, for coated vesicle budding
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GTP + H2O
GDP + phosphate
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GTP hydrolysis is required for clathrin-mediated endocytosis in vivo
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GTP + H2O
GDP + phosphate
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plays a role in clathrin-mediated endocytosis, the endocytically active GTPase dynamin plays a role in the regulation of Trypanosoma cruzi invasion of nonphagocytic cells, dynamin acts as a limiting factor in allowing trypomastigotes to invade host cells
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GTP + H2O
GDP + phosphate
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conformational changes in the active site accompany self-assembly, dynamin domain structure, Thr-65 plays an important role in catalysis, Thr-141 has roles in both GTP binding and hydrolysis
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GTP + H2O
GDP + phosphate
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dynamin is required for the clathrin-independent endocytosis of gamma cytokine receptor
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GTP + H2O
GDP + phosphate
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dynamin-2 facilitates fas protein translocation from the Golgi apparatus via the trans-Golgi network to the cell surface
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GTP + H2O
GDP + phosphate
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GTPase dynamin is required for budding of clathrin-coated vesicles from plasma membrane. Auxilin cooperates with dynamin during vesicle formation. DEscription of four assays that monitor auxilin-dynamin interactions
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GTP + H2O
GDP + phosphate
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involved in vesicle scission
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GTP + H2O
GDP + phosphate
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the dynein/dynactin complex plays an unexpected role in the regulation of mitochondrial morphology in living cells, by controlling the recruitment of Drp1 to these organelles
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GTP + H2O
GDP + phosphate
the recombinant GTPase-GTPase effector domain fusion protein of human Drp1 shows GTPase activity
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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NtDRP3 can bind to and bundle both microtubules and actin filaments in vitro
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTPase is required for endocytosis
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GTP + H2O
GDP + phosphate
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the enzyme is involved in membrane constriction and fission during receptor-mediated endocytosis and synaptic vesicle endocytosis
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GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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regulates late events in clathrin-coated vescicle formation, GTP hydrolysis is required for vesicle detachment, a concerted conformational change resulting from coordinated GTP hydrolysis by the dynamin oligomer might by sufficient to generate force
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?
GTP + H2O
GDP + phosphate
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dynamin 2 can act as a signal transducing GTPase affecting transcriptional regulation
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GTP + H2O
GDP + phosphate
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enzyme is involved in endocytosis
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GTP + H2O
GDP + phosphate
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enzyme is involved in endocytosis
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GTP + H2O
GDP + phosphate
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enzyme is involved in endocytosis
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GTP + H2O
GDP + phosphate
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dynamin I phosphorylation by protein kinase C and dephosphorylation by calcineurin serve as molecular switches to control nerve terminal vesicle recycling
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GTP + H2O
GDP + phosphate
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through its ability to oligomerize, dynamin appears to form a structural collar around the neck of caveolae that hydrolyzes GTP to mediate internalization via the fission of caveolae from the plasma membrane to form free transport vesicles
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GTP + H2O
GDP + phosphate
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dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity
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GTP + H2O
GDP + phosphate
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GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission
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GTP + H2O
GDP + phosphate
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the role of dynamin in the assembly and function of podosomes and invadopodia
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GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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ir
GTP + H2O
GDP + phosphate
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GTP + H2O
GDP + phosphate
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additional information
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DRP5 is involved in cytokinesis
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additional information
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dynamin is a midbody protein associated with membrane remodelling that is also required for cytokinesis. Dynamin may also function as a link between the plasma membrane and actin filaments through interactions with proteins like Abp1, profilin, or cortacin. Alternatively, dynamin assembled on plasma membranes can act as structural component that organizes and stabilizes acti filaments at the furrow membrane, therefore being a platform from which the contractile ring forms.
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additional information
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dynamin is a midbody protein associated with membrane remodelling that is also required for cytokinesis. Dynamin may also function as a link between the plasma membrane and actin filaments through interactions with proteins like Abp1, profilin, or cortacin. Alternatively, dynamin assembled on plasma membranes can act as structural component that organizes and stabilizes acti filaments at the furrow membrane, therefore being a platform from which the contractile ring forms.
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additional information
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dynamin regulates the focal exocytosis of endomembranes at the site of phagocytosis and accumulates on the nascent phagosome in a complex with inactive Vps34 and Rab5-GDP
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additional information
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dynamin regulates the focal exocytosis of endomembranes at the site of phagocytosis and accumulates on the nascent phagosome in a complex with inactive Vps34 and Rab5-GDP
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additional information
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the enzyme mediates homotypic membrane fusion of the endoplasmic reticulum, wild-type scSey1p shows efficient fusion in the presence of GTP and Mg2+. No fusion is seen with GDP or in the absence of Mg2+. Addition of GMP-PNP caused moderate but reproducible fusion. Nucleotide-dependent conformational changes of Sey1p, nucleotide binding structure, detailed overview
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additional information
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the enzyme mediates homotypic membrane fusion of the endoplasmic reticulum, wild-type scSey1p shows efficient fusion in the presence of GTP and Mg2+. No fusion is seen with GDP or in the absence of Mg2+. Addition of GMP-PNP caused moderate but reproducible fusion. Nucleotide-dependent conformational changes of Sey1p, nucleotide binding structure, detailed overview
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additional information
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dynamin is a midbody protein associated with membrane remodelling that is also required for cytokinesis. Dynamin may also function as a link between the plasma membrane and actin filaments through interactions with proteins like Abp1, profilin, or cortacin. Alternatively, dynamin assembled on plasma membranes can act as structural component that organizes and stabilizes acti filaments at the furrow membrane, therefore being a platform from which the contractile ring forms.
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additional information
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the dynamin isoform DlpB is involved in cytokinesis
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additional information
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the dynamin isoform DlpB is involved in cytokinesis
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additional information
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the dynamin isoform DlpB is involved in cytokinesis
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additional information
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the dynamin isoform DlpB is involved in cytokinesis
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additional information
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the dynamin isoform DlpC is involved in cytokinesis
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additional information
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the dynamin isoform DlpC is involved in cytokinesis
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additional information
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the dynamin isoform DlpC is involved in cytokinesis
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additional information
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the dynamin isoform DlpC is involved in cytokinesis
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additional information
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the dynamin isoforms DlpA is involved in cytokinesis
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additional information
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the dynamin isoforms DlpA is involved in cytokinesis
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additional information
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the dynamin isoforms DlpA is involved in cytokinesis
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additional information
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the dynamin isoforms DlpA is involved in cytokinesis
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additional information
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dynamin is a midbody protein associated with membrane remodelling that is also required for cytokinesis. Dynamin may also function as a link between the plasma membrane and actin filaments through interactions with proteins like Abp1, profilin, or cortacin. Alternatively, dynamin assembled on plasma membranes can act as structural component that organizes and stabilizes acti filaments at the furrow membrane, therefore being a platform from which the contractile ring forms.
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additional information
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feline infectious peritonitis virus enters monocytes through a clathrin- and caveolae-independent pathway that strongly depends on dynamin
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additional information
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dynamin 2 regulates granule exocytosis during natural killer cell-mediated cytotoxicity
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additional information
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dynamin assembles at the necks of budded vesicles in vivo and functions in membrane fission, dynamin alone is sufficient to catalyze membrane fission and vesiculation from a fluid membrane reservoir
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additional information
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dynamin is critically involved in membrane fission during endocytosis, dynamin acts as a catalyst of membrane remodelling bringing membrane nanotubes to the point of spontaneous fission via creation of regulated curvature constraints
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additional information
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dynamin is involved in histamine H2 receptor endocytosis
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additional information
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MUC1-CT endocytosis is dynamin dependent
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additional information
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Pichinde virus infection of host cells is dependent on cellular dynamin 2
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additional information
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sorting nexin 9-induced tubulation is antagonized dynamin 2, sorting nexin 9 binds dynamin 2 and N-WASP, and this interaction regulates the tubulating activity of SNX9 in conjunction with the actin cytoskeleton
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additional information
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the complete HIV-1 particle transfer from the effector cells to target primary T CD4+ lymphocytes requires the presence of dynamin
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additional information
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the PH domain binds acidic phospholipids in the cytosolic leaflet of the plasma membrane, and phosphatidylinositol-4,5-bisphosphate in particular, via a positively charged surface at the foot of the dynamin hairpin. The membrane interaction is strengthened by charge-dependent association with other negatively charged phospholipids and by avidity afforded by dynamin polymerization
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additional information
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MxA recognizes Thogoto virus nucleocapsid proteins independently of nucleotide binding, while both nucleotide binding and hydrolysis are required for the antiviral activity against Thogoto, influenza, and La Crosse viruses. GTP binding facilitates formation of stable MxA assemblies associated with endoplasmic reticulum membranes, whereas nucleotide hydrolysis promotes dynamic redistribution of MxAfrom cellular membranes to viral targets
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additional information
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MxA recognizes Thogoto virus nucleocapsid proteins independently of nucleotide binding, while both nucleotide binding and hydrolysis are required for the antiviral activity against Thogoto, influenza, and La Crosse viruses. GTP binding facilitates formation of stable MxA assemblies associated with endoplasmic reticulum membranes, whereas nucleotide hydrolysis promotes dynamic redistribution of MxAfrom cellular membranes to viral targets
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additional information
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enzyme-nucleotide binding studies, overview
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additional information
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enzyme-nucleotide binding studies, overview
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additional information
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analysis of the enzyme in GDP-bound state, the switch I region moves away from the active site after GTP hydrolysis and release of inorganic phosphate
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additional information
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behaviour analysis of the enzyme in nucleotide and/or membrane binding, detailed overview. Nucleotide-dependent changes in PHD-membrane interactions and the non-hydrolyzable GTP analogue, GMPPCP (beta-gamma-methyleneguanosine 5'-triphosphate)-dependent loosening of the scaffold. Ability of wild-type Dyn1, and mutant Dyn1CC and Dyn1Closed to catalyze membrane fission and vesicle release from SUPER templates, overview
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additional information
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dynamin 2 is required for actin assembly in phagocytosis in Sertoli cells, dynamin 2 is involved in PI(4,5)P2-induced actin polymerisation during phagocytosis
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additional information
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dynamin is required for budding of clathrin-coated vesicles from the plasma membrane, functional dynamin is required for muramyl dipeptide-induced internalization and signaling
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additional information
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the PH domain binds acidic phospholipids in the cytosolic leaflet of the plasma membrane, and phosphatidylinositol-4,5-bisphosphate in particular, via a positively charged surface at the foot of the dynamin hairpin. The membrane interaction is strengthened by charge-dependent association with other negatively charged phospholipids and by avidity afforded by dynamin polymerization
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additional information
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in addition to the GTPase domain, neurolastin also has an E3 ubiquitin ligase domain, the enzyme shows E3 ligase activity in an in vitro ubiquitination assay
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additional information
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neurolastin exhibits both GTPase and E3 ligase activities
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additional information
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dynamin interacts with the Gigantea gene in vivo
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additional information
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Arp2/3-mediated actin polymerization regulates the accessibility of cortactin to dynamin 2 and implies a novel mechanism by which cortactin and dynamin drive the fission of clathrin-coated pits in an actin polymerization dependent manner
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additional information
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dynamin 2 is specifically required for clathrin-mediated endocytosis in fibroblastoid cells, p75 export from the Golgi, and PDGF-stimulated macropinocytosis and cytokinesis, but not for other endocytic pathways, clathrin-mediated endocytosis and p75 exocytosis are efficiently rescued by reintroduction of dynamin 2, but not dynamin 1, suggesting that these two isoforms function differentially in vesicular trafficking in nonneuronal cells. Both isoforms rescue macropinocytosis and cytokinesis, suggesting that dynamin function in these processes may be mechanistically distinct from its role in clathrin-mediated endocytosis. Although all four dynamin 2 splice variants can equally restore clathrin-mediated endocytosis, dynamin 2ba and dynamin 2bb are more effective at restoring p75 exocytosis.
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additional information
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dynamin 2 is specifically required for clathrin-mediated endocytosis in fibroblastoid cells, p75 export from the Golgi, and PDGF-stimulated macropinocytosis and cytokinesis, but not for other endocytic pathways, clathrin-mediated endocytosis and p75 exocytosis are efficiently rescued by reintroduction of dynamin 2, but not dynamin 1, suggesting that these two isoforms function differentially in vesicular trafficking in nonneuronal cells. Both isoforms rescue macropinocytosis and cytokinesis, suggesting that dynamin function in these processes may be mechanistically distinct from its role in clathrin-mediated endocytosis. Although all four dynamin 2 splice variants can equally restore clathrin-mediated endocytosis, dynamin 2ba and dynamin 2bb are more effective at restoring p75 exocytosis.
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additional information
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dynamin 2 is specifically required for clathrin-mediated endocytosis in fibroblastoid cells, p75 export from the Golgi, and PDGF-stimulated macropinocytosis and cytokinesis, but not for other endocytic pathways, clathrin-mediated endocytosis and p75 exocytosis are efficiently rescued by reintroduction of dynamin 2, but not dynamin 1, suggesting that these two isoforms function differentially in vesicular trafficking in nonneuronal cells. Both isoforms rescue macropinocytosis and cytokinesis, suggesting that dynamin function in these processes may be mechanistically distinct from its role in clathrin-mediated endocytosis. Although all four dynamin 2 splice variants can equally restore clathrin-mediated endocytosis, dynamin 2ba and dynamin 2bb are more effective at restoring p75 exocytosis.
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additional information
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dynamin is a binding partner of histamine H2 receptor, agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent. Dynamin is not involved in adenylate cyclase activation or desensitisation.
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additional information
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LOX-1 internalisation is regulated by dynamin-2
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additional information
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the PH domain binds acidic phospholipids in the cytosolic leaflet of the plasma membrane, and phosphatidylinositol-4,5-bisphosphate in particular, via a positively charged surface at the foot of the dynamin hairpin. The membrane interaction is strengthened by charge-dependent association with other negatively charged phospholipids and by avidity afforded by dynamin polymerization
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additional information
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Drp6 does not participate in nuclear protein import
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additional information
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DrpB is required during replication to generate vesicles for the regulated secretory pathway that form the unique secretory organelles, DrpB is required for the transport of secretory proteins
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