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Literature summary for 3.6.5.5 extracted from

  • MacGregor, K.A.; Abdel-Hamid, M.K.; Odell, L.R.; Chau, N.; Whiting, A.; Robinson, P.J.; McCluskey, A.
    Development of quinone analogues as dynamin GTPase inhibitors (2014), Eur. J. Med. Chem., 85, 191-206.
    View publication on PubMed
Search for more literature for 3.6.5.5

Inhibitors

Inhibitors Comment Organism Structure
2,5-bis(2-(dimethylamino)ethylamino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(2-(hydroxymethyl)anilino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(2-bromoanilino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(2-carboxyanilino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(3-bromopropylamino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(3-carboxyanilino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(3-hydroxyanilino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(3-methoxyanilino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(3-methoxypropylamino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(4-(hydroxymethyl)phenylamino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(4-carboxyanilino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(4-carboxybenzylamino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(4-hydroxyanilino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(4-hydroxybenzylamino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(4-methoxyanilino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(4-methoxybenzylamino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(hexylamino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis(phenylamino)-1,4-benzoquinone
-
 Ovis aries
2,5-bis-(benzylamino)-1,4-benzoquinone
-
 Ovis aries
2-(2-carboxyanilino)-1,4-naphthoquinone
-
 Ovis aries
2-(3-(hydroxymethyl)anilino)-1,4-naphthoquinone
-
 Ovis aries
2-(3-hydroxyanilino)-1,4-naphthoquinone
-
 Ovis aries
2-(4-(hydroxymethyl)anilino)-1,4-naphthoquinone
-
 Ovis aries
2-(4-hydroxyanilino)-1,4-naphthoquinone
-
 Ovis aries
2-(4-hydroxybenzylamino)-1,4-naphthoquinone
-
 Ovis aries
additional information development of quinone analogues as dynamin GTPase inhibitors, docking study and molecular modelling, overview. No or poor inhibition by 2,5-bis(2-methylanilino)-1,4-benzoquinone, 2,5-bis(2-methoxyanilino)-1,4-benzoquinone, 2,5-bis(3-(hydroxymethyl)phenylamino)-1,4-benzoquinone, 2,5-b+F49is(2-hydroxyethylamino)-1,4-benzoquinone, 2,5-bis(3-hydroxypropylamino)-1,4-benzoquinone, 2,5-bis(4-hydroxybutylamino)-1,4-benzoquinone, 2,5-bis(2-methoxyethylamino)-1,4-benzoquinone, 2,5-bis(2-(methylthio)ethylamino)-1,4-benzoquinone, 2,5-bis(2-chloroethylamino)-1,4-benzoquinone, 2,5-bis(2-bromoethylamino)-1,4-benzoquinone, 2,5-bis(3-chloropropylamino)-1,4-benzoquinone, 2,5-bis(3-pyridylmethylamino)-1,4-benzoquinone, 2,5-bis(4-methylbenzylamino)-1,4-benzoquinone, 2,5-bis(4-fluorobenzylamino)-1,4-benzoquinone, 2,5-bis(4-bromobenzylamino)-1,4-benzoquinone, 2,5-bis(4-chlorobenzylamino)-1,4-benzoquinone, 2,5-bis(phenethylamino)-1,4-benzoquinone, 2,5-bis(ethylamino)-1,4-benzoquinone, 2,5-bis(propylamino)-1,4-benzoquinone, 2,5-bis(butylamino)-1,4-benzoquinone, 2,5-bis(pentylamino)-1,4-benzoquinone, 2,5-bis(isopentylamino)-1,4-benzoquinone, 2,5-bis(allylamino)-1,4-benzoquinone, 2-(2-hydroxyethylamino)-1,4-naphthoquinone, 2-(3-hydroxypropylamino)-1,4-naphthoquinone, 2-(anilino)-1,4-naphthoquinone, 2-(3-carboxyanilino)-1,4-naphthoquinone, 2-(4-carboxyanilino)-1,4-naphthoquinone, 2-(benzylamino)-1,4-naphthoquinone, and 2-(4-methoxybenzylamino)-1,4-naphthoquinone Ovis aries

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane peripheral membrane fraction Ovis aries 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Ovis aries
-
 GDP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from sheep brain membrane fraction by affinity chromatography Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Ovis aries GDP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
dynamin GTPase
-
 Ovis aries
dynamin I GTPase
-
 Ovis aries
dynI GTPase
-
 Ovis aries

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0106
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-carboxyanilino)-1,4-benzoquinone
0.0111
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-hydroxyanilino)-1,4-benzoquinone
0.0215
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-(hydroxymethyl)phenylamino)-1,4-benzoquinone
0.0224
-
 pH and temperature not specified in the publication Ovis aries 2-(4-hydroxyanilino)-1,4-naphthoquinone
0.0254
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(3-carboxyanilino)-1,4-benzoquinone
0.029
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-carboxybenzylamino)-1,4-benzoquinone
0.0295
-
 pH and temperature not specified in the publication Ovis aries 2-(4-(hydroxymethyl)anilino)-1,4-naphthoquinone
0.0303
-
 pH and temperature not specified in the publication Ovis aries 2-(3-(hydroxymethyl)anilino)-1,4-naphthoquinone
0.0502
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(2-carboxyanilino)-1,4-benzoquinone
0.0579
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(3-hydroxyanilino)-1,4-benzoquinone
0.109
-
 pH and temperature not specified in the publication Ovis aries 2-(3-hydroxyanilino)-1,4-naphthoquinone
0.112
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-hydroxybenzylamino)-1,4-benzoquinone
0.116
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(3-methoxypropylamino)-1,4-benzoquinone
0.15
-
 pH and temperature not specified in the publication Ovis aries 2-(4-hydroxybenzylamino)-1,4-naphthoquinone
0.17
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-methoxybenzylamino)-1,4-benzoquinone
0.273
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis-(benzylamino)-1,4-benzoquinone
0.3
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(hexylamino)-1,4-benzoquinone
0.3
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(2-(dimethylamino)ethylamino)-1,4-benzoquinone
0.3
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(3-methoxyanilino)-1,4-benzoquinone
0.3
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-methoxyanilino)-1,4-benzoquinone
0.3
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(2-(hydroxymethyl)anilino)-1,4-benzoquinone
0.314
-
 pH and temperature not specified in the publication Ovis aries 2-(2-carboxyanilino)-1,4-naphthoquinone
0.387
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(2-bromoanilino)-1,4-benzoquinone
0.58
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(3-bromopropylamino)-1,4-benzoquinone