Application | Comment | Organism |
---|---|---|
medicine | mutations in the dynamin family GTPase OPA1 are reportedly the cause of autosomal dominant optic atrophy | Mus musculus |
Cloned (Comment) | Organism |
---|---|
wild-type mOPA1 and its mutants are subcloned into the mammalian expression vector pCNX2 for transfection of COS-7 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
D273A | OPA1 missense mutation associated with autosomal dominant optic atrophy | Mus musculus |
E270K | OPA1 missense mutation associated with autosomal dominant optic atrophy | Mus musculus |
K301A | loss of function mutation within the G1 GTP-binding domain | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial inner membrane | - |
Mus musculus | 5743 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
anti-mOPA1 antibodies detect a double band of approximately 90 and 80 kDa | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Mus musculus | - |
GDP + phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P58281 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Mus musculus | GDP + phosphate | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
dynamin-related GTPase | - |
Mus musculus |
mOPA1 | - |
Mus musculus |
OPA1 | - |
Mus musculus |