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Literature summary for 3.6.5.5 extracted from
- Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization (2008), Mol. Pharmacol., 74, 1109-1118.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in COS-7 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K44A | dominant-negative mutants of dynamin, the mutant is defective in its GTP binding site, effectively blocking dynamin-mediated endocytosis at a stage after the initiation of the coat assembly and preceding the sequestration into deeply invaginated coated pits | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | dynamin is involved in histamine H2 receptor endocytosis | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| U-937 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? | |
| additional information | dynamin is involved in histamine H2 receptor endocytosis | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dynamin | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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