Information on EC 3.6.5.5 - dynamin GTPase

Word Map on EC 3.6.5.5
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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.6.5.5
-
RECOMMENDED NAME
GeneOntology No.
dynamin GTPase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GTP + H2O = GDP + phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
NIL
-
-
SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (vesicle-releasing)
An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles.
CAS REGISTRY NUMBER
COMMENTARY hide
9059-32-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Bright Yellow 2
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain FcB1
UniProt
Manually annotated by BRENDA team
strain FcB1
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O
ADP + phosphate
show the reaction diagram
-
dynamin also has ATPase activity
-
-
-
GTP + H2O
GDP + phosphate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Zn2+
-
binding coordinates are conserved
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2R)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropane-1-carboxamide
-
milnacipran
(2E)-2-cyano-N-(3-[[(2E)-2-cyano-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]propyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
-
-
(2E)-2-cyano-N-(3-[[(2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoyl]amino]propyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
-
-
(2E)-2-cyano-N-(3-[[(2E)-2-cyano-3-phenylprop-2-enoyl]amino]propyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
-
-
(2E,2'E)-N,N'-(2-hydroxypropane-1,3-diyl)bis[2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide]
-
-
(2E,2'E)-N,N'-(2-phenoxypropane-1,3-diyl)bis[2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide]
-
-
(2E,2'E)-N,N'-(2-propoxypropane-1,3-diyl)bis[2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide]
-
-
(3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidine
-
paroxetine
(5Z)-3-(prop-2-en-1-yl)-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-(2H-chromen-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-(3,5-dichlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-(4-bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-(biphenyl-4-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-[4-[3-(dimethylamino)propoxy]benzylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-ethyl-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-3-benzyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-3-benzyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2H-chromen-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2H-chromen-3-ylmethylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2H-chromen-3-ylmethylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(3,5-dichlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(3,5-dichlorobenzylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(3,5-dichlorobenzylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(4-bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(4-bromobenzylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(4-bromobenzylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(biphenyl-4-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(biphenyl-4-ylmethylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(biphenyl-4-ylmethylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine
-
mianserin
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro[2]benzofuran-5-carbonitrile
-
citalopram
10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine
-
desipramine
2,5-bis(2-(dimethylamino)ethylamino)-1,4-benzoquinone
-
-
2,5-bis(2-(hydroxymethyl)anilino)-1,4-benzoquinone
-
-
2,5-bis(2-bromoanilino)-1,4-benzoquinone
-
-
2,5-bis(2-carboxyanilino)-1,4-benzoquinone
-
-
2,5-bis(3-bromopropylamino)-1,4-benzoquinone
-
-
2,5-bis(3-carboxyanilino)-1,4-benzoquinone
-
-
2,5-bis(3-hydroxyanilino)-1,4-benzoquinone
-
-
2,5-bis(3-methoxyanilino)-1,4-benzoquinone
-
-
2,5-bis(3-methoxypropylamino)-1,4-benzoquinone
-
-
2,5-bis(4-(hydroxymethyl)phenylamino)-1,4-benzoquinone
-
-
2,5-bis(4-carboxyanilino)-1,4-benzoquinone
-
-
2,5-bis(4-carboxybenzylamino)-1,4-benzoquinone
-
-
2,5-bis(4-hydroxyanilino)-1,4-benzoquinone
-
-
2,5-bis(4-hydroxybenzylamino)-1,4-benzoquinone
-
-
2,5-bis(4-methoxyanilino)-1,4-benzoquinone
-
-
2,5-bis(4-methoxybenzylamino)-1,4-benzoquinone
-
-
2,5-bis(hexylamino)-1,4-benzoquinone
-
-
2,5-bis(phenylamino)-1,4-benzoquinone
-
-
2,5-bis-(benzylamino)-1,4-benzoquinone
-
-
2-((8-chlorodibenzo(b,f)thiepin-10-yl)oxy)-N,N-dimethylethylamine
-
zotepine
2-(2-carboxyanilino)-1,4-naphthoquinone
-
-
2-(3-(hydroxymethyl)anilino)-1,4-naphthoquinone
-
-
2-(3-hydroxyanilino)-1,4-naphthoquinone
-
-
2-(4-(hydroxymethyl)anilino)-1,4-naphthoquinone
-
-
2-(4-hydroxyanilino)-1,4-naphthoquinone
-
-
2-(4-hydroxybenzylamino)-1,4-naphthoquinone
-
-
2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]butyl ester
-
IC50: 0.061 mM
2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]ethyl ester
-
IC50: 0.042 mM
2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]propyl ester
-
IC50: 0.038 mM
2-cyano-N-[2-[2-cyano-3-(3,4,5-trihydroxyphenyl)acryloylamino]ethyl]-3-(3,4,5-trihydroxyphenyl)acrylamide
-
IC50: 0.0017 mM
2-cyano-N-[2-[2-cyano-3-(3,4-dihydroxy-4-methoxyphenyl)acryloylamino]ethyl]-3-(3,4-dihydroxy-5-methoxyphenyl) acrylamide
-
IC50: 0.009 mM
2-cyano-N-[3-[2-cyano-3-(3,4,5-trihydroxyphenyl)acryloylamino]hexyl]-3-(3,4,5-trihydroxyphenyl)acrylamide
-
IC50: 0.006 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxy-phenyl)acryloylamino]hexyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide
-
IC50: 0.08 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxy-phenyl)acryloylamino]pentyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide
-
IC50: 0.008 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxyphenyl)acryloylamino]butyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide
-
IC50: 0.008 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxyphenyl)acryloylamino]propyl]-3-(3,4-dihydroxy-5-meth-oxyphenyl)acrylamide
-
IC50: 0.005 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-2-hydroxypropyl]-3-(3,4-dihydroxyphenyl)acrylamide
-
IC50: 0.0051 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-propyl] 3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]acrylamide
-
-
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
-
nortriptyline
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
-
chlorpromazine
3-(4-azidophenyl)-2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]propyl]acrylamide
-
-
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
-
imipramine
3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
-
clomipramine
3-sulfo-N-(2-hydroxyethyl)-1,8-naphthalimide
-
-
3-[(5Z)-4-oxo-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(2H-chromen-3-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(3,5-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(4-bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(biphenyl-4-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
4-(N,N-dimethyl-N-butyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-(N,N-dimethyl-N-dodecyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione bromide
-
-
4-(N,N-dimethyl-N-dodecyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxa-6-ethyltricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxa-6-methyltricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione bromide
-
-
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-(N,N-dimethyl-N-octadecyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione bromide
-
-
4-(N-methyl-N-ethylpiperidine)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-amino-3-sulfo-N-(2-(dimethylamino)ethyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(2-(piperazin-1-yl)ethyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(2-aminobenzyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(2-aminoethyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(2-carboxyethyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(2-hydroxyethyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(2-mercaptoethyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(2-methoxyethyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(3-aminobenzyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(3-hydroxyphenyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(3-hydroxypropyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(4-aminobenzyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(4-carboxybenzyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(4-hydroxybenzyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(4-hydroxyphenyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(4-methoxyphenyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(5-hydroxyhexyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(5-hydroxypentyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(carboxymethyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-(phenethyl)-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-benzyl-1,8-naphthalimide
-
-
4-amino-3-sulfo-N-phenyl-1,8-naphthalimide
-
-
4-azido-N-(2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-1-[[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]methyl]ethyl)-2,3,5,6-tetrafluorobenzamide
-
-
4-sulfo-N-(2-hydroxyethyl)-1,8-naphthalimide
-
-
4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one
-
haloperidol
5H-dibenz[b,f]azepine-5-carboxamide
-
carbamazepine
-
beta,gamma-methyleneguanosine-5'-monophosphate
-
-
bis-tyrphostin
-
potent inhibitor of the phospholipid-stimulated GTPase activity of dynamin
Ca2+
-
inhibits dynamin I GTPase activity after stimulation by phosphorylation or by phospholipids but not after stimulation a glutathione S-transferase-SH3 fusion protein containing the SH3-domain of phosphoinositide 3-kinase
catechol-acrylamide
-
IC50: 0.0051 mM
cyclosporin A
treating BL-3 cells with 0.005 mM cyclosporine depletes mitochondrial dynamin-2
dynamin inhibitory peptide
-
-
-
dynasore
fluvoxamine
-
a noncompetitive inhibitor of dynamin I with respect to GTP and a competitive inhibitor with respect to L-phosphatidylserine
GTP-gamma-S
-
-
guanylyl-iminodiphosphate
-
-
heterotrimeric G protein betagamma subunit complex
-
methyl 2-phenyl-2-(2-piperidyl)acetate
-
methylphenidate
mitochondrial division inhibitor
-
selectively inhibits the mitochondrial division dynamin, is a selective inhibitor of the mitochondrial division dynamin-related GTPase Drp1, and has no effect on either basal or assembly-stimulated rates of GTP hydrolysis for dynamin-1
-
myristyl trimethyl ammonium bromide
-
standard inhibitor of dynamin I
N-(2-diethylaminoethyl)-2-methoxy-5-methylsulfonyl-benzamide
-
tiapride
N-(2-hydroxyethyl)-1,8-naphthalimide
-
-
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine
-
fluoxetine
N-methyl-9,10-ethanoanthracene-9(10H)-propanamine
-
maprotiline
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide
-
sulpiride
N-[2-[[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-1-([[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]methyl)ethyl]benzamide
-
-
NEM
-
-
oligomeric beta-amyloid
-
induces dynamin 1 cleavage and depletion, 0.001 mM of A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 cleavage
-
sertraline
-
a mixed type inhibitor with respect to both GTP and L-phosphatidylserine
[(5Z)-4-oxo-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
-
[(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
-
[(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
-
[(5Z)-5-(2H-chromen-3-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
-
[(5Z)-5-(3,5-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
-
[(5Z)-5-(4-bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
-
[(5Z)-5-(biphenyl-4-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
-
[(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
-
[(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
-
[(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-O-(1,2-di-O-palmitoyl-sn-glycerol-3-benzyloxyphosphoryl)-D-myo-inositol 3,4,5-triphosphate
amphiphysin
-
stimulation of dynamin GTPase activity
-
anionic liposome
-
potent stimulation of dynamin GTPase activity at low ionic strength, activator interacts with the highly basic C-terminal proline/arginine-rich domain of dynamin via ionic interactions that are essentially abrogated at physiologic ionic strength
-
antibodies
-
stimulate by crosslinking through the C-terminal proline-rich domain of dynamin
-
endogenouse rat brain vesicles
-
cooperative interactions between dynamin molecules are responsible for the apparent activation of GTPase observed
-
Grb2
-
L-phosphatidylserine
-
binds the pleckstrin homology domain of dynamin and enhances its GTPase activity
-
lipid tubule
-
stimulate GTPase activity
-
microtubule
-
microtubules
-
phosphatidylglycerol
-
stimulates
phosphatidylinositol
-
stimulates
phosphatidylinositol 3,4-bisphosphate
-
weak activation, binds to the pleckstrin homology domain
phosphatidylinositol 4,5-bisphosphate
-
activates the GTPase activity of dynamin, specific for D-5 phosphoinositides, activation mechanism, activates also in the presence of 100-130 mM NaCl, the interactions are mediated by the dynamin pleckstrin homology domain
phosphatidylinositol-4,5-bisphosphate
phosphatidylserine
-
stimulates
phosphatidylserine liposomes
-
-
-
phospholipase D
-
PLD function as a GTPase activating protein, GAP, through its phox homology domain, PX, which directly activates the GTPase domain of dynamin
-
Phospholipid
SH3 domain-containing protein
-
activates the GTPase activity of dynamin, activation mechanism
-
SH3 domains
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0034 - 2.115
GTP
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0003 - 3.1
GTP
additional information
additional information
Homo sapiens
-
kinetic data, temperature-dependent effects on kinetic parameters
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
(1R,2R)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropane-1-carboxamide
Mus musculus
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.044
(2E)-2-cyano-N-(3-[[(2E)-2-cyano-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]propyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
Ovis aries
-
in 10 mM Tris, 10 mM NaCl, 2 mM Mg2, at 30°C
0.051
(2E)-2-cyano-N-(3-[[(2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoyl]amino]propyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
Ovis aries
-
in 10 mM Tris, 10 mM NaCl, 2 mM Mg2, at 30°C
0.146
(2E)-2-cyano-N-(3-[[(2E)-2-cyano-3-phenylprop-2-enoyl]amino]propyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
Ovis aries
-
in 10 mM Tris, 10 mM NaCl, 2 mM Mg2, at 30°C
0.0051
(2E,2'E)-N,N'-(2-hydroxypropane-1,3-diyl)bis[2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide]
Ovis aries
-
in 10 mM Tris, 10 mM NaCl, 2 mM Mg2, at 30°C
0.5
(2E,2'E)-N,N'-(2-phenoxypropane-1,3-diyl)bis[2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide]
Ovis aries
-
IC50 above 0.5 mM, in 10 mM Tris, 10 mM NaCl, 2 mM Mg2, at 30°C
0.5
(2E,2'E)-N,N'-(2-propoxypropane-1,3-diyl)bis[2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide]
Ovis aries
-
IC50 above 0.5 mM, in 10 mM Tris, 10 mM NaCl, 2 mM Mg2, at 30°C
0.0234
(3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidine
Mus musculus
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.05
(5Z)-3-benzyl-5-(3,5-dichlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.134
(5Z)-3-benzyl-5-(4-bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0074
(5Z)-3-benzyl-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.022
(5Z)-3-benzyl-5-[4-[3-(dimethylamino)propoxy]benzylidene]-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0074
(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.053
(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-3-benzyl-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.09
(5Z)-5-(2H-chromen-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0075
(5Z)-5-(3,5-dichlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.031
(5Z)-5-(3,5-dichlorobenzylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0031
(5Z)-5-(3,5-dichlorobenzylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.043
(5Z)-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0055
(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.029
(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0051
(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0045
(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0071
(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.1
1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine
Mus musculus
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.1
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro[2]benzofuran-5-carbonitrile
Mus musculus
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.1
10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine
Mus musculus
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.3
2,5-bis(2-(dimethylamino)ethylamino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.3
2,5-bis(2-(hydroxymethyl)anilino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.387
2,5-bis(2-bromoanilino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.0502
2,5-bis(2-carboxyanilino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.58
2,5-bis(3-bromopropylamino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.0254
2,5-bis(3-carboxyanilino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.0579
2,5-bis(3-hydroxyanilino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.3
2,5-bis(3-methoxyanilino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.116
2,5-bis(3-methoxypropylamino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.0215
2,5-bis(4-(hydroxymethyl)phenylamino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.0106
2,5-bis(4-carboxyanilino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.029
2,5-bis(4-carboxybenzylamino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.0111
2,5-bis(4-hydroxyanilino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.112
2,5-bis(4-hydroxybenzylamino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.3
2,5-bis(4-methoxyanilino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.17
2,5-bis(4-methoxybenzylamino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.3
2,5-bis(hexylamino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.273
2,5-bis-(benzylamino)-1,4-benzoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.314
2-(2-carboxyanilino)-1,4-naphthoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.0303
2-(3-(hydroxymethyl)anilino)-1,4-naphthoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.109
2-(3-hydroxyanilino)-1,4-naphthoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.0295
2-(4-(hydroxymethyl)anilino)-1,4-naphthoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.0224
2-(4-hydroxyanilino)-1,4-naphthoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.15
2-(4-hydroxybenzylamino)-1,4-naphthoquinone
Ovis aries
-
pH and temperature not specified in the publication
0.061
2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]butyl ester
Ovis aries
-
IC50: 0.061 mM
0.042
2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]ethyl ester
Ovis aries
-
IC50: 0.042 mM
0.038
2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]propyl ester
Ovis aries
-
IC50: 0.038 mM
0.0017
2-cyano-N-[2-[2-cyano-3-(3,4,5-trihydroxyphenyl)acryloylamino]ethyl]-3-(3,4,5-trihydroxyphenyl)acrylamide
Ovis aries
-
IC50: 0.0017 mM
0.009
2-cyano-N-[2-[2-cyano-3-(3,4-dihydroxy-4-methoxyphenyl)acryloylamino]ethyl]-3-(3,4-dihydroxy-5-methoxyphenyl) acrylamide
Ovis aries
-
IC50: 0.009 mM
0.006
2-cyano-N-[3-[2-cyano-3-(3,4,5-trihydroxyphenyl)acryloylamino]hexyl]-3-(3,4,5-trihydroxyphenyl)acrylamide
Ovis aries
-
IC50: 0.006 mM
0.08
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxy-phenyl)acryloylamino]hexyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide
Ovis aries
-
IC50: 0.08 mM
0.008
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxy-phenyl)acryloylamino]pentyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide
Ovis aries
-
IC50: 0.008 mM
0.008
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxyphenyl)acryloylamino]butyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide
Ovis aries
-
IC50: 0.008 mM
0.005
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxyphenyl)acryloylamino]propyl]-3-(3,4-dihydroxy-5-meth-oxyphenyl)acrylamide
Ovis aries
-
IC50: 0.005 mM
0.0051
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-2-hydroxypropyl]-3-(3,4-dihydroxyphenyl)acrylamide
Ovis aries
-
IC50: 0.0051 mM
0.0369
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-propyl] 3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]acrylamide
Ovis aries
-
in 10 mM Tris, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.0372
2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine
Mus musculus
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.064
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Mus musculus
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.0472
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
Mus musculus
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.0064
3-(4-azidophenyl)-2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]propyl]acrylamide
Ovis aries
-
in 10 mM Tris, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.1
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Mus musculus
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.0299
3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Mus musculus
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.3
3-sulfo-N-(2-hydroxyethyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.0235
3-[(5Z)-5-(2H-chromen-3-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0044
3-[(5Z)-5-(3,5-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.096
3-[(5Z)-5-(4-bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.042
3-[(5Z)-5-(biphenyl-4-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.048
3-[(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.01
3-[(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.404
4-(N,N-dimethyl-N-butyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
Ovis aries
-
-
0.0085
4-(N,N-dimethyl-N-dodecyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione bromide
Ovis aries
-
-
0.0089
4-(N,N-dimethyl-N-dodecyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
Ovis aries
-
-
0.0068
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxa-6-ethyltricyclo[5.2.1]decane-3,5-dione methanesulfonate
Ovis aries
-
-
0.0118
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxa-6-methyltricyclo[5.2.1]decane-3,5-dione methanesulfonate
Ovis aries
-
-
0.0084
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione bromide
Ovis aries
-
-
0.0112
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
Ovis aries
-
-
0.0023
4-(N,N-dimethyl-N-octadecyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione bromide
Ovis aries
-
-
0.043
4-(N-methyl-N-ethylpiperidine)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
Ovis aries
-
-
0.509
4-amino-3-sulfo-N-(2-(dimethylamino)ethyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.155
4-amino-3-sulfo-N-(2-aminobenzyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.3
4-amino-3-sulfo-N-(2-aminoethyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.094
4-amino-3-sulfo-N-(2-carboxyethyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.193
4-amino-3-sulfo-N-(2-hydroxyethyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.088
4-amino-3-sulfo-N-(3-aminobenzyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.159
4-amino-3-sulfo-N-(3-hydroxyphenyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.093
4-amino-3-sulfo-N-(3-hydroxypropyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.123
4-amino-3-sulfo-N-(4-aminobenzyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.0185
4-amino-3-sulfo-N-(4-carboxybenzyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.0448
4-amino-3-sulfo-N-(4-hydroxybenzyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.296
4-amino-3-sulfo-N-(4-hydroxyphenyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.113
4-amino-3-sulfo-N-(5-hydroxyhexyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.062
4-amino-3-sulfo-N-(5-hydroxypentyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.0191
4-amino-3-sulfo-N-(carboxymethyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.0703
4-amino-3-sulfo-N-benzyl-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.3
4-amino-3-sulfo-N-phenyl-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.5
4-azido-N-(2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-1-[[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]methyl]ethyl)-2,3,5,6-tetrafluorobenzamide
Ovis aries
-
IC50 above 0.5 mM, in 10 mM Tris, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.3
4-sulfo-N-(2-hydroxyethyl)-1,8-naphthalimide
Homo sapiens
-
pH 7.4, 37°C
0.1
4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one
Mus musculus
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.1
5H-dibenz[b,f]azepine-5-carboxamide
Mus musculus
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
-
0.0017
bis-tyrphostin
Ovis aries
-
in 10 mM Tris, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.0051
catechol-acrylamide
Ovis aries
-
IC50: 0.0051 mM
0.0147
fluvoxamine
Mus musculus
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.1
methyl 2-phenyl-2-(2-piperidyl)acetate
Mus musculus
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.0241
myristyl trimethyl ammonium bromide
Mus musculus
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.1
N-(2-diethylaminoethyl)-2-methoxy-5-methylsulfonyl-benzamide
Mus musculus
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.0334
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine
Mus musculus
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.0211
N-methyl-9,10-ethanoanthracene-9(10H)-propanamine
Mus musculus
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.1
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide
Mus musculus
-
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.5
N-[2-[[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-1-([[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]methyl)ethyl]benzamide
Ovis aries
-
IC50 above 0.5 mM, in 10 mM Tris, 10 mM NaCl, 2 mM Mg2, at 30°C
0.0073
sertraline
Mus musculus
-
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C
0.0055
[(5Z)-5-(3,5-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.073
[(5Z)-5-(biphenyl-4-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0123
[(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0034
[(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.16
-
the specific rate of GTP hydrolysis of dynamin stimulated by the PLDs-PX
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 7.4
-
assay at
7 - 8
-
assay at
7.2
-
radioactive assay for the GTPase activity
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20
-
assay at
30
-
assay at
additional information
-
assay at room temperature
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22 - 37
-
both the basal and assembly-stimulated rates of GTP hydrolysis for wild-type dynamin are 10fold lower when assayed at 22°C compared with 37°C, effect of these temperatures on the Km
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
-
predicted pI-value
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
dynamin localizes to newly formed cleavage furrow membranes and accumulates at the midbody of dividing embryos
Manually annotated by BRENDA team
-
dynamin-1, endocrine cell of the gastric mucosa; dynamin-2, endocrine cell of the gastric mucosa; low abundance of dynamin-3, endocrine cell of the gastric mucosa
Manually annotated by BRENDA team
dynamin 3 participates in the growth and development of megakaryocytes
Manually annotated by BRENDA team
-
dynamin2 is ubiquitously expressed, while dynamin1 is restricted to the nervous system
Manually annotated by BRENDA team
-
photoreceptor cell
Manually annotated by BRENDA team
-
CHO cell line
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE