3.6.5.5: dynamin GTPase

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For detailed information about dynamin GTPase, go to the full flat file.

Reaction

Synonyms

AtDRP1A, B-dynamin , caSey1p, D100 , dDyn, DLC1, DLP-1, DLP1, DlpA, DlpB, DlpC, Dnm1, DNM1L, DNM2, DNM3, DRP, Drp1, Drp1-long, Drp1-short, DRP1E, DRP5A, Drp6, DrpB, Dyn, Dyn I, Dyn-1, Dyn1, DYN2, Dyn2aa, Dyn2ab, Dyn2ba, Dyn2bb, Dyn3, dynamin, dynamin 1, dynamin 1 GTPase, dynamin 1aa, dynamin 2, dynamin 2aa, dynamin 3, dynamin 3aa, Dynamin BREDNM19 , dynamin family GTPase, dynamin GTPase, dynamin I, dynamin I GTPase, dynamin I guanosine triphosphatase, Dynamin UDNM , Dynamin, brain , Dynamin, testicular , dynamin-1, dynamin-1 GTPase, dynamin-1-like GTPase, dynamin-1-like protein, dynamin-2, dynamin-3, dynamin-like GTPase, dynamin-like guanosine triphosphatase, dynamin-like guanosine-triphosphate hydrolase, dynamin-like myxovirus resistance protein A, dynamin-like protein 1, dynamin-like protein 6, dynamin-related GTPase, dynamin-related protein, dynamin-related protein 1, dynamin-related protein 1 isoform 3, dynamin-related protein 1A, dynamin-related protein 1E, dynamin-related protein 2A, dynamin-related protein B, dynamin-retated GTPase Drp1, dynamin1, dynamin2, dynamin2 GTPase, dynamine-related GTPase, dynein light chain 1, dynI, dynI GTPase, EC 3.6.1.50, fission dynamin, GTP phosphohydrolase, GTPase, GTPase dynamin, GTPase dynamin-1, GTPase dynamin-related protein 1, guanine triphosphatase, guanosine 5'-triphosphatase, guanosine triphosphatase, hDrp1 isoform 3, large GTPase, Mfn1, mitochondrial division dynamin, mitochondrial dynamin, mitochondrial inner membrane fusion dynamin Mgm1, mitofusin 1, mOPA1, multidomain GTPase, Mx GTPase, MX1, MxA, myxovirus resistance GTPase, neurolastin, Nicotiana tabacum dynamin-related protein 3, NtDRP3, OPA1, optic atrophy 1, PfDYN2, phosphatase, guanosine tri-, Protein shibire, ribosomal GTPase, Sey1p, Shibire protein , T-dynamin , Vps1p

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.5 Acting on GTP to facilitate cellular and subcellular movement

                3.6.5.5 dynamin GTPase

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Results	in table
61	Activating Compound
13562	AA Sequence
6	Application
1	CAS Registry Number
54	Cloned(Commentary)
6	Crystallization (Commentary)
2621	Disease/ Diagnostics
91	General Information
124	IC50 Value
252	Inhibitors
43	KM Value [mM]
120	Localization
22	Metals/Ions
16	Molecular Weight [Da]
115	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
147	Organism
114	PDB ID
18	pH Optimum
1	pI Value
4	Posttranslational Modification
117	Protein Variants
39	Purification (Commentary)
3	Reaction
18	Reaction Type
138	Reference
2	Renatured (Commentary)
105	Source Tissue
2	Specific Activity [micromol/min/mg]
186	Substrates and Products (Substrate)
42	Subunits
278	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
1	Temperature Range [°C]
26	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 3.6.5.5 - dynamin GTPase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

phosphoprotein

Rattus norvegicus

-

Drp1 is specifically phosphorylated in mitosis by Cdk1/cyclin B on Ser-585

687540

side-chain modification

Rattus norvegicus

-

dynamin I phosphorylation by protein kinase C and dephosphorylation by calcineurin serve as molecular switches to control nerve terminal vesicle recycling

644181

ubiquitination

Mus musculus

Q8K1M6

ubiquitin-mediated regulation of dynamin GTPases serves as a quality control mechanism for maintaining mitochondrial dynamics

757219

additional information

Homo sapiens

O00429

actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

756570