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3.6.5.5: dynamin GTPase

This is an abbreviated version!
For detailed information about dynamin GTPase, go to the full flat file.

Word Map on EC 3.6.5.5

Reaction

GTP
+
H2O
=
GDP
 +
phosphate

Synonyms

AtDRP1A, B-dynamin , caSey1p, D100 , dDyn, DLC1, DLP-1, DLP1, DlpA, DlpB, DlpC, Dnm1, DNM1L, DNM2, DNM3, DRP, Drp1, Drp1-long, Drp1-short, DRP1E, DRP5A, Drp6, DrpB, Dyn, Dyn I, Dyn-1, Dyn1, DYN2, Dyn2aa, Dyn2ab, Dyn2ba, Dyn2bb, Dyn3, dynamin, dynamin 1, dynamin 1 GTPase, dynamin 1aa, dynamin 2, dynamin 2aa, dynamin 3, dynamin 3aa, Dynamin BREDNM19 , dynamin family GTPase, dynamin GTPase, dynamin I, dynamin I GTPase, dynamin I guanosine triphosphatase, Dynamin UDNM , Dynamin, brain , Dynamin, testicular , dynamin-1, dynamin-1 GTPase, dynamin-1-like GTPase, dynamin-1-like protein, dynamin-2, dynamin-3, dynamin-like GTPase, dynamin-like guanosine triphosphatase, dynamin-like guanosine-triphosphate hydrolase, dynamin-like myxovirus resistance protein A, dynamin-like protein 1, dynamin-like protein 6, dynamin-related GTPase, dynamin-related protein, dynamin-related protein 1, dynamin-related protein 1 isoform 3, dynamin-related protein 1A, dynamin-related protein 1E, dynamin-related protein 2A, dynamin-related protein B, dynamin-retated GTPase Drp1, dynamin1, dynamin2, dynamin2 GTPase, dynamine-related GTPase, dynein light chain 1, dynI, dynI GTPase, EC 3.6.1.50, fission dynamin, GTP phosphohydrolase, GTPase, GTPase dynamin, GTPase dynamin-1, GTPase dynamin-related protein 1, guanine triphosphatase, guanosine 5'-triphosphatase, guanosine triphosphatase, hDrp1 isoform 3, large GTPase, Mfn1, mitochondrial division dynamin, mitochondrial dynamin, mitochondrial inner membrane fusion dynamin Mgm1, mitofusin 1, mOPA1, multidomain GTPase, Mx GTPase, MX1, MxA, myxovirus resistance GTPase, neurolastin, Nicotiana tabacum dynamin-related protein 3, NtDRP3, OPA1, optic atrophy 1, PfDYN2, phosphatase, guanosine tri-, Protein shibire, ribosomal GTPase, Sey1p, Shibire protein , T-dynamin , Vps1p

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.5 Acting on GTP to facilitate cellular and subcellular movement
                3.6.5.5 dynamin GTPase

Inhibitors

Inhibitors on EC 3.6.5.5 - dynamin GTPase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2R)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropane-1-carboxamide
-
milnacipran
(2-chloro-6-methylpyrimidin-4-yl)butylamine
-
(2-chloro-6-methylpyrimidin-4-yl)cyclohexylamine
-
(2-chloro-6-methylpyrimidin-4-yl)cyclopropylmethylpropylamine
-
(2-chloro-6-methylpyrimidin-4-yl)decylamine
-
(2-chloro-6-methylpyrimidin-4-yl)dimethylamine
-
(2-chloro-6-methylpyrimidin-4-yl)ethylamine
-
(2-chloro-6-methylpyrimidin-4-yl)hexylamine
-
(2-chloro-6-methylpyrimidin-4-yl)octylamine
-
(2-chloro-6-methylpyrimidin-4-yl)propylamine
-
(2-chloro-6-methylpyrimidin-4-yl)tetradecylamine
-
(2E)-2-cyano-N-(3-[[(2E)-2-cyano-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]propyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
-
-
(2E)-2-cyano-N-(3-[[(2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoyl]amino]propyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
-
-
(2E)-2-cyano-N-(3-[[(2E)-2-cyano-3-phenylprop-2-enoyl]amino]propyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
-
-
(2E,2'E)-N,N'-(2-hydroxypropane-1,3-diyl)bis[2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide]
-
-
(2E,2'E)-N,N'-(2-phenoxypropane-1,3-diyl)bis[2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide]
-
-
(2E,2'E)-N,N'-(2-propoxypropane-1,3-diyl)bis[2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide]
-
-
(3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidine
-
paroxetine
(4-chloro-6-methylpyrimidin-2-yl)(1-cyclopropylmethylpropyl)amine
-
(4-chloro-6-methylpyrimidin-2-yl)-dimethylamine
-
(4-chloro-6-methylpyrimidin-2-yl)butylamine
-
(4-chloro-6-methylpyrimidin-2-yl)cyclohexylamine
-
(4-chloro-6-methylpyrimidin-2-yl)decylamine
-
(4-chloro-6-methylpyrimidin-2-yl)hexylamine
-
(4-chloro-6-methylpyrimidin-2-yl)octylamine
-
(4-chloro-6-methylpyrimidin-2-yl)propylamine
-
(4-chloro-6-methylpyrimidin-2-yl)tetradecylamine
-
(5Z)-3-(prop-2-en-1-yl)-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-(2H-chromen-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-(3,5-dichlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-(4-bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-(biphenyl-4-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-benzyl-5-[4-[3-(dimethylamino)propoxy]benzylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-3-ethyl-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-3-benzyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-3-benzyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2H-chromen-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2H-chromen-3-ylmethylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(2H-chromen-3-ylmethylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(3,5-dichlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(3,5-dichlorobenzylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(3,5-dichlorobenzylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(4-bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(4-bromobenzylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(4-bromobenzylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(biphenyl-4-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(biphenyl-4-ylmethylidene)-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(biphenyl-4-ylmethylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
-
(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
-
1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine
-
mianserin
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro[2]benzofuran-5-carbonitrile
-
citalopram
10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine
-
desipramine
2,5-bis(2-(dimethylamino)ethylamino)-1,4-benzoquinone
-
-
2,5-bis(2-(hydroxymethyl)anilino)-1,4-benzoquinone
-
-
2,5-bis(2-bromoanilino)-1,4-benzoquinone
-
-
2,5-bis(2-carboxyanilino)-1,4-benzoquinone
-
-
2,5-bis(3-bromopropylamino)-1,4-benzoquinone
-
-
2,5-bis(3-carboxyanilino)-1,4-benzoquinone
-
-
2,5-bis(3-hydroxyanilino)-1,4-benzoquinone
-
-
2,5-bis(3-methoxyanilino)-1,4-benzoquinone
-
-
2,5-bis(3-methoxypropylamino)-1,4-benzoquinone
-
-
2,5-bis(4-(hydroxymethyl)phenylamino)-1,4-benzoquinone
-
-
2,5-bis(4-carboxyanilino)-1,4-benzoquinone
-
-
2,5-bis(4-carboxybenzylamino)-1,4-benzoquinone
-
-
2,5-bis(4-hydroxyanilino)-1,4-benzoquinone
-
-
2,5-bis(4-hydroxybenzylamino)-1,4-benzoquinone
-
-
2,5-bis(4-methoxyanilino)-1,4-benzoquinone
-
-
2,5-bis(4-methoxybenzylamino)-1,4-benzoquinone
-
-
2,5-bis(hexylamino)-1,4-benzoquinone
-
-
2,5-bis(phenylamino)-1,4-benzoquinone
-
-
2,5-bis-(benzylamino)-1,4-benzoquinone
-
-
2-((8-chlorodibenzo(b,f)thiepin-10-yl)oxy)-N,N-dimethylethylamine
-
zotepine
2-(2-carboxyanilino)-1,4-naphthoquinone
-
-
2-(2-dimethylaminoethyl)-4-N-(didecylamino)-6-methylpyrimidine
-
2-(3-(hydroxymethyl)anilino)-1,4-naphthoquinone
-
-
2-(3-hydroxyanilino)-1,4-naphthoquinone
-
-
2-(4-(hydroxymethyl)anilino)-1,4-naphthoquinone
-
-
2-(4-hydroxyanilino)-1,4-naphthoquinone
-
-
2-(4-hydroxybenzylamino)-1,4-naphthoquinone
-
-
2-chloro-4-(2-dimethylaminopropylamine)-6-methylpyrimidine
-
2-chloro-5-methyl-4-(4-methylpiperazin-1-yl)pyrimidine
-
2-chloro-N-(4-methoxybenzyl)-6-methylpyrimidin-4-amine
-
2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]butyl ester
-
IC50: 0.061 mM
2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]ethyl ester
-
IC50: 0.042 mM
2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloyloxy]propyl ester
-
IC50: 0.038 mM
2-cyano-N-[2-[2-cyano-3-(3,4,5-trihydroxyphenyl)acryloylamino]ethyl]-3-(3,4,5-trihydroxyphenyl)acrylamide
-
IC50: 0.0017 mM
2-cyano-N-[2-[2-cyano-3-(3,4-dihydroxy-4-methoxyphenyl)acryloylamino]ethyl]-3-(3,4-dihydroxy-5-methoxyphenyl) acrylamide
-
IC50: 0.009 mM
2-cyano-N-[3-[2-cyano-3-(3,4,5-trihydroxyphenyl)acryloylamino]hexyl]-3-(3,4,5-trihydroxyphenyl)acrylamide
-
IC50: 0.006 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxy-phenyl)acryloylamino]hexyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide
-
IC50: 0.08 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxy-phenyl)acryloylamino]pentyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide
-
IC50: 0.008 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxyphenyl)acryloylamino]butyl]-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide
-
IC50: 0.008 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxy-5-methoxyphenyl)acryloylamino]propyl]-3-(3,4-dihydroxy-5-meth-oxyphenyl)acrylamide
-
IC50: 0.005 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-2-hydroxypropyl]-3-(3,4-dihydroxyphenyl)acrylamide
-
IC50: 0.0051 mM
2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-propyl] 3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]acrylamide
-
-
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
-
nortriptyline
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
-
chlorpromazine
3-(4-azidophenyl)-2-cyano-N-[3-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]propyl]acrylamide
-
-
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
-
imipramine
3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
-
clomipramine
3-sulfo-N-(2-hydroxyethyl)-1,8-naphthalimide
-
3-[(5Z)-4-oxo-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(2H-chromen-3-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(3,5-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(4-bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-(biphenyl-4-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
3-[(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
-
-
4-(2-dimethylaminoethyl)-2-N-(didecylamino)-6-methylpyrimidine
-
4-(N,N-dimethyl-N-butyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-(N,N-dimethyl-N-dodecyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione bromide
-
-
4-(N,N-dimethyl-N-dodecyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxa-6-ethyltricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxa-6-methyltricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione bromide
-
-
4-(N,N-dimethyl-N-dodecyl-N-propyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-(N,N-dimethyl-N-octadecyl-N-ethyl)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione bromide
-
-
4-(N-methyl-N-ethylpiperidine)-4-aza-10-oxatricyclo[5.2.1]decane-3,5-dione methanesulfonate
-
-
4-amino-3-sulfo-N-(2-(dimethylamino)ethyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(2-(piperazin-1-yl)ethyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(2-aminobenzyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(2-aminoethyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(2-carboxyethyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(2-hydroxyethyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(2-mercaptoethyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(2-methoxyethyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(3-aminobenzyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(3-hydroxyphenyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(3-hydroxypropyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(4-aminobenzyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(4-carboxybenzyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(4-hydroxybenzyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(4-hydroxyphenyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(4-methoxyphenyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(5-hydroxyhexyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(5-hydroxypentyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(carboxymethyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-(phenethyl)-1,8-naphthalimide
-
4-amino-3-sulfo-N-benzyl-1,8-naphthalimide
-
4-amino-3-sulfo-N-phenyl-1,8-naphthalimide
-
4-azido-N-(2-[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-1-[[2-cyano-3-(3,4-dihydroxyphenyl)acryloylamino]methyl]ethyl)-2,3,5,6-tetrafluorobenzamide
-
-
4-chloro-6-methyl-2-(4-methylpiperazin-1-yl)pyrimidine
-
4-chloro-N-(4-methoxybenzyl)-6-methylpyrimidin-2-amine
-
4-sulfo-N-(2-hydroxyethyl)-1,8-naphthalimide
-
4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one
-
haloperidol
5H-dibenz[b,f]azepine-5-carboxamide
-
carbamazepine
Arc/Arg3.1
enhances dynamin polymerization and GTPase activity. The activity-regulated cytoskeleton-associated protein, Arc, is an immediate-early gene product implicated in various forms of synaptic plasticity. Arc promotes endocytosis of AMPA type glutamate receptors and regulates cytoskeletal assembly in neuronal dendrites. Bacterially-expressed His6-Arc facilitates the polymerization of Dyn2 and stimulates its GTPase activity under physiologic conditions (37°C and 100 mM NaCl). At lower ionic strength Arc also stabilizes preformed Dyn2 polymers against GTP-dependent disassembly, thereby prolonging assembly-dependent GTP hydrolysis catalyzed by Dyn2. Analysis of recombinant full-length mouse Arc and of His6-tagged fragments, including Arc-N (residues 1-227), Arc-C (residues 228-396), and Arc-(DELTA195-214). At physiologic ionic strength, Arc facilitates Dyn2 self-assembly but does not prevent GTP-dependent Dyn2 disassembly, which is expected to suppress rather than activate endocytosis
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beta,gamma-methyleneguanosine-5'-monophosphate
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bis-tyrphostin
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potent inhibitor of the phospholipid-stimulated GTPase activity of dynamin
Ca2+
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inhibits dynamin I GTPase activity after stimulation by phosphorylation or by phospholipids but not after stimulation a glutathione S-transferase-SH3 fusion protein containing the SH3-domain of phosphoinositide 3-kinase
catechol-acrylamide
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IC50: 0.0051 mM
cyclosporin A
treating BL-3 cells with 0.005 mM cyclosporine depletes mitochondrial dynamin-2
dynamin inhibitory peptide
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dynasore
fluvoxamine
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a noncompetitive inhibitor of dynamin I with respect to GTP and a competitive inhibitor with respect to L-phosphatidylserine
GTP-gamma-S
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guanylyl-iminodiphosphate
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heterotrimeric G protein betagamma subunit complex
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methyl 2-phenyl-2-(2-piperidyl)acetate
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methylphenidate
mitochondrial division inhibitor
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selectively inhibits the mitochondrial division dynamin, is a selective inhibitor of the mitochondrial division dynamin-related GTPase Drp1, and has no effect on either basal or assembly-stimulated rates of GTP hydrolysis for dynamin-1
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myristyl trimethyl ammonium bromide
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standard inhibitor of dynamin I
N'-(2-chloro-6-methylpyrimidin-4-yl)ethane-1,2-diamine
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N'-(4-Chloro-6-methylpyrimidin-2-yl)-ethane-1,2-diamine
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N-(2-diethylaminoethyl)-2-methoxy-5-methylsulfonyl-benzamide
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tiapride
N-(2-hydroxyethyl)-1,8-naphthalimide
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N-benzyl-2-chloro-6-methylpyrimidin-4-amine
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N-benzyl-4-chloro-6-methylpyrimidin-2-amine
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N-decyl-N'-(2-dimethylaminoethyl)-pyrimidine-4,6-diamine
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N-dodecyl-N'-(2-dimethylaminoethyl)pyrimidine-4,6-diamine
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N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine
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fluoxetine
N-methyl-9,10-ethanoanthracene-9(10H)-propanamine
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maprotiline
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide
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sulpiride
N-[2-[[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-1-([[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]methyl)ethyl]benzamide
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N1-(4-chloro-6-methylpyrimidin-2-yl)-N3,N3-dimethylpropane-1,3-diamine
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N2-(2-dimethylaminoethyl)-6-methyl-N4-octadecylpyrimidine-2,4-diamine
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N2-(2-dimethylaminoethyl)-6-methyl-N4-propylpyrimidine-2,4-diamine
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N2-(2-dimethylaminoethyl)-6-methyl-N4-tetradecylpyrimidine-2,4-diamine
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N2-(2-dimethylaminoethyl)-N4-decyl-6-methylpyrimidine-2,4-diamine
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N2-(2-dimethylaminoethyl)-N4-hexyl-6-methylpyrimidine-2,4-diamine
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N2-(2-dimethylaminoethyl)-N4-octyl-6-methylpyrimidine-2,4-diamine
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N2-benzyl-N4-(2-dimethylaminoethyl)-6-methylpyrimidine-2,4-diamine
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N2-butyl-N4-(2-dimethylaminoethyl)-6-methylpyrimidine-2,4-diamine
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N2-cyclohexyl-N4-(2-dimethylaminoethyl)-6-methylpyrimidine-2,4-diamine
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N2-cyclopropylmethyl-N4-(2-dimethylamin-ethyl)-6-methyl-N2-propylpyrimidine-2,4-diamine
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N2-decyl-N4-(2-dimethylaminoethyl)pyrimidine-2,4-diamine
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N2-dodecyl-N4-(2-dimethylaminoethyl)-pyrimidine-2,4-diamine
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N2-sec-butyl-N4-(2-dimethylaminoethyl)-6-methylpyrimidine-2,4-diamine
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N4-(2-dimethylaminoethyl)-6-methyl-N2-octadecylpyrimidine-2,4-diamine
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N4-(2-dimethylaminoethyl)-6-methyl-N2-propylpyrimidine-2,4-diamine
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N4-(2-dimethylaminoethyl)-6-methyl-N2-tetradecylpyrimidine-2,4-diamine
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N4-(2-dimethylaminoethyl)-N2-decyl-6-methylpyrimidine-2,4-diamine
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N4-(2-dimethylaminoethyl)-N2-hexyl-6-methylpyrimidine-2,4-diamine
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N4-(2-dimethylaminoethyl)-N2-octyl-6-methylpyrimidine-2,4-diamine
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N4-Benzyl-N2-(2-dimethylaminoethyl)-6-methylpyrimidine-2,4-diamine
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N4-butyl-N2-(2-dimethylaminoethyl)-6-methylpyrimidine-2,4-diamine
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N4-cyclohexyl-N2-(2-dimethylaminoethyl)-6-methylpyrimidine-2,4-diamine
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N4-cyclopropylmethyl-N2-(2-dimethylamin-ethyl)-6-methyl-N2-propylpyrimidine-2,4-diamine
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N4-decyl-N2-(2-dimethylaminoethyl)pyrimidine-2,4-diamine
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N4-dodecyl-N2-(2-dimethylaminoethyl)pyrimidine-2,4-diamine
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N4-sec-butyl-N2-(2-dimethylaminoethyl)-6-methylpyrimidine-2,4-diamine
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NEM
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oligomeric beta-amyloid
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induces dynamin 1 cleavage and depletion, 0.001 mM of A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 cleavage
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sec-butyl-(2-chloro-6-methylpyrimidin-4-yl)amine
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sec-butyl-(4-chloro-6-methylpyrimidin-2-yl)amine
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sertraline
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a mixed type inhibitor with respect to both GTP and L-phosphatidylserine
[(5Z)-4-oxo-5-(quinoxalin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[(5Z)-5-(2,1,3-benzothiadiazol-5-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[(5Z)-5-(2,1,3-benzoxadiazol-5-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[(5Z)-5-(2H-chromen-3-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[(5Z)-5-(3,5-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[(5Z)-5-(4-bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[(5Z)-5-(biphenyl-4-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[(5Z)-5-[(5-chloro-1-benzothiophen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[(5Z)-5-[(6,8-dichloro-4-oxo-4H-chromen-3-yl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[(5Z)-5-[4-[3-(dimethylamino)propoxy]benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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[2-(2-chloro-6-methylpyrimidin-4-ylamino)ethyl]carbamic acid tert-butyl ester
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[2-(4-chloro-6-methylpyrimidin-2-ylamino)ethyl]carbamic acid tert-butyl ester
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additional information
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