3.4.21.B27: proprotein convertase 7
This is an abbreviated version!
For detailed information about proprotein convertase 7, go to the full flat file.
Word Map on EC 3.4.21.B27
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3.4.21.B27
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furin
-
tmprss6
-
endoproteases
-
pcsks
-
medicine
-
pafah1b2
-
hemochromatosis
-
furin-like
-
pnpla3
-
mbtps1
- 3.4.21.B27
- furin
- tmprss6
- endoproteases
-
pcsks
- medicine
- pafah1b2
- hemochromatosis
-
furin-like
-
pnpla3
-
mbtps1
Reaction
cleaves proteins typically at sites marked by the consensus Arg-Xaa-(Lys/Arg)-Arg sequence =
Synonyms
furin, LPC, lymphoma PC, PC-7, PC7, PC7A, PC7B, PCSK7, Proprotein convertase, proprotein convertase 7, proprotein convertase PCSK7, proprotein convertase subtilisin/kexin type 7, rPC7, S08.077, SPC7, subtilisin-like proprotein convertase 7
ECTree
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Reference on EC 3.4.21.B27 - proprotein convertase 7
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tsuji, A.; Hine, C.; Mori, K.; Tamai, Y.; Higashine, K.; Nagamune, H.; Matsuda, Y.
A novel member, PC7, of the mammalian kexin-like protease family: homology to PACE4A, its brain-specific expression and identification of isoforms
Biochem. Biophys. Res. Commun.
202
1452-1459
1994
Rattus norvegicus (Q63793)
Nakayama, K.
Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins
Biochem. J.
327
625-635
1997
Mammalia
-
Basak, A.; Cooper, S.; Roberge, A.G.; Banik, U.K.; Chretien, M.; Seidah, N.G.
Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters
Biochem. J.
338
107-113
1999
Homo sapiens
-
Basak, A.; Zhong, M.; Munzer, J.S.; Chretien, M.; Seidah, N.G.
Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides
Biochem. J.
353
537-545
2001
Rattus norvegicus
Bhattacharjya, S.; Xu, P.; Zhong, M.; Chretien, M.; Seidah, N.G.; Ni, F.
Inhibitory activity and structural characterization of a C-terminal peptide fragment derived from the prosegment of the proprotein convertase PC7
Biochemistry
39
2868-2877
2000
Rattus norvegicus
Munzer, J.S.; Basak, A.; Zhong, M.; Mamarbachi, A.; Hamelin, J.; Savaria, D.; Lazure, C.; Hendy, G.N.; Benjannet, S.; Chretien, M.; Seidah, N.G.
In vitro characterization of the novel proprotein convertase PC7
J. Biol. Chem.
272
19672-19681
1997
Rattus norvegicus
Zhong, M.; Munzer, J.S.; Basak, A.; Benjannet, S.; Mowla, S.J.; Decroly, E.; Chretien, M.; Seidah, N.G.
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity
J. Biol. Chem.
274
33913-33920
1999
Rattus norvegicus
Siegfried, G.; Basak, A.; Cromlish, J.A.; Benjannet, S.; Marcinkiewicz, J.; Chretien, M.; Seidah, N.G.; Khatib, A.M.
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis
J. Clin. Invest.
111
1723-1732
2003
Rattus norvegicus
Basak, A.; Ernst, B.; Brewer, D.; Seidah, N.G.; Munzer, J.S.; Lazure, C.; Lajoie, G.A.
Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1
J. Pept. Res.
49
596-603
1997
Rattus norvegicus
Cammisotto, P.G.; Gingras, D.; Renaud, C.; Levy, E.; Bendayan, M.
Secretion of soluble leptin receptors by exocrine and endocrine cells of the gastric mucosa
Am. J. Physiol. Gastrointest. Liver Physiol.
290
G242-G249
2006
Rattus norvegicus
Seidah, N.G.; Chretien, M.
Proprotein convertase 7
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
2
1877-1880
2004
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus
-
Page, R.E.; Klein-Szanto, A.J.; Litwin, S.; Nicolas, E.; Al-Jumaily, R.; Alexander, P.; Godwin, A.K.; Ross, E.A.; Schilder, R.J.; Bassi, D.E.
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer
Cell. Oncol.
29
289-299
2007
Homo sapiens
Fugere, M.; Appel, J.; Houghten, R.A.; Lindberg, I.; Day, R.
Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences
Mol. Pharmacol.
71
323-332
2007
Homo sapiens
Freyer, C.; Kilpatrick, L.M.; Salamonsen, L.A.; Nie, G.
Pro-protein convertases (PCs) other than PC6 are not tightly regulated for implantation in the human endometrium
Reproduction
133
1189-1197
2007
Homo sapiens (Q16549)
Padua, M.B.; Hansen, P.J.
Regulation of DNA synthesis and the cell cycle in human prostate cancer cells and lymphocytes by ovine uterine serpin
BMC Cell Biol.
9
5
2008
Mus musculus
Jarvinen, M.; Chinnaswamy, K.; Sturtevant, A.; Hatley, N.; Sucic, J.
Effects of age and retinal degeneration on the expression of proprotein convertases in the visual cortex
Brain Res.
1317
1-12
2010
Mus musculus
Nelsen, S.M.; Christian, J.L.
Site-specific cleavage of BMP4 by furin, PC6, and PC7
J. Biol. Chem.
284
27157-27166
2009
Xenopus laevis
Rousselet, E.; Benjannet, S.; Hamelin, J.; Canuel, M.; Seidah, N.
The proprotein convertase PC7: Unique zymogen activation and trafficking pathways
J. Biol. Chem.
286
2728-2738
2011
Homo sapiens, Rattus norvegicus
Rousselet, E.; Benjannet, S.; Marcinkiewicz, E.; Asselin, M.; Lazure, C.; Seidah, N.
Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor
J. Biol. Chem.
286
9185-9195
2011
Homo sapiens, Mus musculus
Leonhardt, R.; Fiegl, D.; Rufer, E.; Karger, A.; Bettin, B.; Knittler, M.
Post-endoplasmic reticulum rescue of unstable MHC class I requires proprotein convertase PC7
J. Immunol.
184
2985-2998
2010
Homo sapiens
Guillemot, J.; Canuel, M.; Essalmani, R.; Prat, A.; Seidah, N.G.
Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin
Hepatology
57
2514-2524
2013
Homo sapiens (Q16549)
Schwienbacher, C.; Serafin, A.; Zanon, A.; Pramstaller, P.; Pichler, I.; Hicks, A.
Involvement of proprotein convertase PCSK7 in the regulation of systemic iron homeostasis
Hepatology
58
1860-1861
2013
Homo sapiens (Q16549)
Turpeinen, H.; Oksanen, A.; Kivinen, V.; Kukkurainen, S.; Uusimaeki, A.; Raemet, M.; Parikka, M.; Hytoenen, V.P.; Nykter, M.; Pesu, M.
Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor beta1a (TGFbeta1a)
J. Biol. Chem.
288
36610-36623
2013
Danio rerio (F1R440), Danio rerio
Senturker, S.; Thomas, J.T.; Mateshaytis, J.; Moos, M.
A homolog of subtilisin-like proprotein convertase 7 is essential to anterior neural development in Xenopus
PLoS ONE
7
e39380
2012
Xenopus laevis (E1U2Y7)
Ginefra, P.; Filippi, B.G.H.; Donovan, P.; Bessonnard, S.; Constam, D.B.
Compartment-specific biosensors reveal a complementary subcellular distribution of bioactive furin and PC7
Cell Rep.
22
2176-2189
2018
Homo sapiens (Q16549), Mus musculus (Q61139)
Declercq, J.; Ramos-Molina, B.; Sannerud, R.; Brouwers, B.; Pruniau, V.P.E.G.; Meulemans, S.; Plets, E.; Annaert, W.; Creemers, J.W.M.
Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines
Eur. J. Cell Biol.
96
432-439
2017
Rattus norvegicus (Q62849)
Bessonnard, S.; Mesnard, D.; Constam, D.
PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation
J. Cell Biol.
210
1185-1197
2015
Mus musculus (Q61139)
Pelucchi, S.; Galimberti, S.; Greni, F.; Rametta, R.; Mariani, R.; Pelloni, I.; Girelli, D.; Busti, F.; Ravasi, G.; Valsecchi, M.G.; Valenti, L.; Piperno, A.
Proprotein convertase 7 rs236918 associated with liver fibrosis in Italian patients with HFE-related hemochromatosis
J. Gastroenterol. Hepatol.
31
1342-1348
2016
Homo sapiens (Q16549), Homo sapiens
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