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Literature summary for 3.4.21.B27 extracted from

  • Seidah, N.G.; Chretien, M.
    Proprotein convertase 7 (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press, 2, 1877-1880.
No PubMed abstract available
Search for more literature for 3.4.21.B27

Application

Application Comment Organism
medicine may have a role in immunity or in defence mechanisms Mus musculus
medicine plays a role in Alzheimer´s disease by participating in the non-amyloidogenic pathway through the activation of alpha-secretase, can also contribute to pro-parathyroid hormone activation, could participate in the activation of viral surface glycoproteins including the HIV gp160 type I glycoprotein, seems likely that perturbance of the levels of PC7 could lead to cancer of lymphatic tissues, could be important in cell proliferation Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockout mice, significant change in the architecture of the thymus and spleen Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
alpha1-PDX
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum autocatalytic proenzyme processing Homo sapiens 5783
-
endoplasmic reticulum autocatalytic proenzyme processing Rattus norvegicus 5783
-
membrane proenzyme Homo sapiens 16020
-
membrane proenzyme Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
89000
-
 mature enzyme Rattus norvegicus
101000
-
 glycosylated proenzyme Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
lymphocyte T-lymphocyte including CD4+ cells Homo sapiens
-
neuron
-
 Rattus norvegicus
-
spleen
-
 Mus musculus
-
spleen expressed more in the white pulp than in the red pulp Rattus norvegicus
-
thymus
-
 Mus musculus
-
thymus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
HIV-1 gp160 + H2O
-
 Homo sapiens HIV1 gp120 + gp41
-
 ?
Lys-Ser-Val-Lys-Lys-Arg-Ser-Val-Ser-Glu-Ile-Gln-Leu + H2O
-
 Homo sapiens Lys-Ser-Val-Lys-Lys-Arg + Ser-Val-Ser-Glu-Ile-Gln-Leu
-
 ?
additional information general recognition sequence of either Arg/Lys-Arg- or Arg/Lys-(Xaa)n-Arg- Rattus norvegicus ?
-
 ?
additional information no cleavage of HIV-1 gp120 into gp77 + gp53 Homo sapiens ?
-
 ?
proneuroendocrine protein 7B2 + H2O
-
 Homo sapiens neuroendocrine protein 7B2
-
 ?
Tyr-Glu-Thr-Leu-Arg-Arg-Arg-Val-Lys-Arg-Ser-Leu-Val-Val-Pro-Thr-Asp + H2O
-
 Rattus norvegicus Tyr-Glu-Thr-Leu-Arg-Arg-Arg-Val-Lys-Arg + Ser-Leu-Val-Val-Pro-Thr-Asp
-
 ?

Synonyms

Synonyms Comment Organism
LPC
-
 Homo sapiens
lymphoma PC
-
 Homo sapiens
PC7
-
 Rattus norvegicus