Literature summary for 3.4.21.B27 extracted from

Basak, A.; Ernst, B.; Brewer, D.; Seidah, N.G.; Munzer, J.S.; Lazure, C.; Lajoie, G.A.
Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1 (1997), J. Pept. Res., 49, 596-603.

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Inhibitors

Inhibitors	Comment	Organism	Structure
histatin-3	competitive, reversible, strong inhibitor	Rattus norvegicus
histatin-5	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pGlu-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O	-	Rattus norvegicus	pGlu-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0024	-	histatin-3	pH 6.5	Rattus norvegicus
0.0123	-	histatin-5	pH 6.5	Rattus norvegicus

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Release 2023.1 (January 2023)