3.4.21.B27: proprotein convertase 7
This is an abbreviated version!
For detailed information about proprotein convertase 7, go to the full flat file.
Word Map on EC 3.4.21.B27
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3.4.21.B27
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furin
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tmprss6
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endoproteases
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pcsks
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medicine
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pafah1b2
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hemochromatosis
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furin-like
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pnpla3
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mbtps1
- 3.4.21.B27
- furin
- tmprss6
- endoproteases
-
pcsks
- medicine
- pafah1b2
- hemochromatosis
-
furin-like
-
pnpla3
-
mbtps1
Reaction
cleaves proteins typically at sites marked by the consensus Arg-Xaa-(Lys/Arg)-Arg sequence =
Synonyms
furin, LPC, lymphoma PC, PC-7, PC7, PC7A, PC7B, PCSK7, Proprotein convertase, proprotein convertase 7, proprotein convertase PCSK7, proprotein convertase subtilisin/kexin type 7, rPC7, S08.077, SPC7, subtilisin-like proprotein convertase 7
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Application
Application on EC 3.4.21.B27 - proprotein convertase 7
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medicine
additional information
compartment-specific biosensors can be used to gain insight into the regulation of proprotein convertase (PC) trafficking and to map the tropism of PC-specific inhibitors
medicine
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plays a role in Alzheimer´s disease by participating in the non-amyloidogenic pathway through the activation of alpha-secretase, can also contribute to pro-parathyroid hormone activation, could participate in the activation of viral surface glycoproteins including the HIV gp160 type I glycoprotein, seems likely that perturbance of the levels of PC7 could lead to cancer of lymphatic tissues, could be important in cell proliferation
medicine
PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-hemochromatosis