3.4.21.B27: proprotein convertase 7
This is an abbreviated version!
For detailed information about proprotein convertase 7, go to the full flat file.
Word Map on EC 3.4.21.B27
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3.4.21.B27
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furin
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tmprss6
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endoproteases
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pcsks
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medicine
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pafah1b2
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hemochromatosis
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furin-like
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pnpla3
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mbtps1
- 3.4.21.B27
- furin
- tmprss6
- endoproteases
-
pcsks
- medicine
- pafah1b2
- hemochromatosis
-
furin-like
-
pnpla3
-
mbtps1
Reaction
cleaves proteins typically at sites marked by the consensus Arg-Xaa-(Lys/Arg)-Arg sequence =
Synonyms
furin, LPC, lymphoma PC, PC-7, PC7, PC7A, PC7B, PCSK7, Proprotein convertase, proprotein convertase 7, proprotein convertase PCSK7, proprotein convertase subtilisin/kexin type 7, rPC7, S08.077, SPC7, subtilisin-like proprotein convertase 7
ECTree
3.4.21.B27 proprotein convertase 7Advanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.21.B27 - proprotein convertase 7
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-GGRRTRREAI-(3-nitro)-Tyr-A + H2O
?
-
fluorogenic substrate encompassing the processing site of envelope glycoproteins of ebola virus
-
?
2-aminobenzoyl-RNTPRERRRKKRGL-(3-nitro)-Tyr-A + H2O
?
-
fluorogenic substrate encompassing the processing site of envelope glycoproteins of Hong Kong virus
-
?
2-aminobenzoyl-SKKRKRRFLG-(3-nitro)-Tyr-A + H2O
?
-
fluorogenic substrate encompassing the processing site of envelope glycoproteins of respiratory syncytial virus
-
?
human immunodeficiency virus envelope glycoprotein pg160 + H2O
?
-
-
-
?
KEKR-4-methylcoumarin 7-amide + H2O
KEKR + 7-amino-4-methylcoumarin
-
weak substrate
-
?
L-pyroglutamyl-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O
L-pyroglutamyl-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Lys-Ser-Val-Lys-Lys-Arg-Ser-Val-Ser-Glu-Ile-Gln-Leu + H2O
Lys-Ser-Val-Lys-Lys-Arg + Ser-Val-Ser-Glu-Ile-Gln-Leu
-
-
-
-
?
Notch 1 + H2O
?
PC7 complements furin (EC 3.4.21.75) in cleaving Notch1 independently of PLC motif-mediated trans-Golgi network access
-
-
?
pGlu-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O
pGlu-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
pro-bone morphogenetic protein 4 + H2O
bone morphogenetic protein 4 + ?
-
PC7, or a convertase with similar substrate specificity, functions to selectively cleave the S1 site of pro-BMP4 in a developmentally regulated fashion
-
-
?
pyro-ERTKR-7-amido-4-methylcoumarin + H2O
pyro-ERTKR + 7-amino-4-methylcoumarin
-
-
-
-
?
Q-VEGF-C + H2O
VEGF-C + ?
-
intramolecularly quenched fluorogenic peptide
-
?
Q-VHSIIRRSLP + H2O
Q-VHSIIRR + SLP
-
synthetic fluorigenic peptide mimicking the cleavage site of pro-VEGF-C
-
?
RFAR-4-methylcoumarin 7-amide + H2O
RFAR + 7-amino-4-methylcoumarin
-
weak substrate
-
?
RKKR-4-methylcoumarin 7-amide + H2O
RKKR + 7-amino-4-methylcoumarin
-
-
-
?
RVRR-4-methylcoumarin 7-amide + H2O
RVRR + 7-amino-4-methylcoumarin
-
weak substrate
-
?
Tyr-Glu-Thr-Leu-Arg-Arg-Arg-Val-Lys-Arg-Ser-Leu-Val-Val-Pro-Thr-Asp + H2O
Tyr-Glu-Thr-Leu-Arg-Arg-Arg-Val-Lys-Arg + Ser-Leu-Val-Val-Pro-Thr-Asp
-
-
-
-
?
YEKERSKR-4-methylcoumarin 7-amide + H2O
YEKERSKR + 7-amino-4-methylcoumarin
-
-
-
?
human transferrin receptor 1 + H2O
?
cleavage at an atypical site KTECER-/-LA
-
-
?
human transferrin receptor 1 + H2O
?
cleavage at an atypical site KTECER-/-LA, in which the P1 Arg100 and P6 Lys95 are critical,.cleavage at Arg100
-
-
?
human transferrin receptor 1 + H2O
?
cleavage at an atypical site KTECER-/-LA, in which the P1 Arg100 and P6 Lys95 are critical, cleavage at Arg100. Identification of the KTECER100;LA cleavage site by site-directed mutagenesis using substrate mutants, overview
-
-
?
pERTKR-4-methylcoumarin 7-amide + H2O
pERTKR + 7-amino-4-methylcoumarin
-
-
-
?
pERTKR-4-methylcoumarin 7-amide + H2O
pERTKR + 7-amino-4-methylcoumarin
-
-
-
?
pERTKR-4-methylcoumarin 7-amide + H2O
pERTKR + 7-amino-4-methylcoumarin
-
-
-
?
preprohepcidin + H2O
?
-
key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin
-
-
?
preprohepcidin + H2O
?
-
key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin. PC7 processes this peptide at the cleavage site of preprohepcidin PMFQRRRRR-/-, resulting in a major 1305 Da N-terminal product. Two minor products with masses of 149 Da and 993 Da are also detected which correspond to the loss of one (PMFQRRRR) or two (PMFQRRR) C-terminal Arg, respectively
-
-
?
pro-VEGF-C + H2O
VEGF-C + ?
-
cleaves at the physiological HSIIRRSL site after R227
-
?
pro-VEGF-C + H2O
VEGF-C + ?
-
pro-VEGF-C processing is required for VEGF-C induced tumor antiogenesis and lymphangiogenesis
-
?
RSKR-4-methylcoumarin 7-amide + H2O
RSKR + 7-amino-4-methylcoumarin
-
-
-
?
RSKR-4-methylcoumarin 7-amide + H2O
RSKR + 7-amino-4-methylcoumarin
-
weak substrate
-
?
additional information
?
-
-
soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor
-
-
?
additional information
?
-
-
the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s)
-
-
?
additional information
?
-
hemojuvelin is not directly cleaved by the enzyme despite the presence of a RNRR motif. No activity on hepcidin
-
-
?
additional information
?
-
-
soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor
-
-
?
additional information
?
-
-
the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s)
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-
?
additional information
?
-
-
general recognition sequence of either Arg/Lys-Arg- or Arg/Lys-(Xaa)n-Arg-
-
-
?
additional information
?
-
-
the PC7 precursor protein undergoes efficient autocatalytic activation in both oocytes and embryos. PC7 requires a P2 basic residue to cleave a substrate
-
-
?
