3.4.21.B27: proprotein convertase 7

This is an abbreviated version!
For detailed information about proprotein convertase 7, go to the full flat file.

Reaction

cleaves proteins typically at sites marked by the consensus Arg-Xaa-(Lys/Arg)-Arg sequence =

Synonyms

furin, LPC, lymphoma PC, PC-7, PC7, PC7A, PC7B, PCSK7, Proprotein convertase, proprotein convertase 7, proprotein convertase PCSK7, proprotein convertase subtilisin/kexin type 7, rPC7, S08.077, SPC7, subtilisin-like proprotein convertase 7

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B27 proprotein convertase 7

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
6	AA Sequence
4	Application
1	CAS Registry Number
12	Cloned(Commentary)
49	Disease/ Diagnostics
3	Expression
20	General Information
26	Inhibitors
14	Ki Value [mM]
8	KM Value [mM]
27	Localization
3	Metals/Ions
9	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
34	Organism
2	pH Optimum
8	Posttranslational Modification
7	Protein Variants
2	Purification (Commentary)
1	Reaction
18	Reaction Type
34	Reference
40	Source Tissue
48	Substrates and Products (Substrate)
4	Subunits
37	Synonyms
1	Temperature Optimum [°C]

Inhibitors

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Inhibitors on EC 3.4.21.B27 - proprotein convertase 7

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Inhibitor Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

14-dehydroandrographolide 3,19-O-disuccinoyl monoester

Homo sapiens

-

-

649658

14-dehydroandrographolide succinoyl monoester

2 entries

alpha1-PDX

Homo sapiens

-

-

673911

-

andrographolide 3alpha,14alpha,19-O-trisuccinate

Homo sapiens

-

-

649658

andrographolide 3alpha,14beta,19-O-trisuccinate

Homo sapiens

-

-

649658

CuSO4

Rattus norvegicus

-

97% inhibition at 1 mM

651865

D-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

D-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

decanoyl-RVKR-chloromethylketone

Homo sapiens

Q16549

-

731888

EAVLAKHEAVRWHSEQRLLKRAKR

Rattus norvegicus

-

C-terminal region of the PC7 prosegment, strong inhibition, competitive

649961

EDTA

Rattus norvegicus

-

95% inhibition at 10 mM

651865

histatin-3

Rattus norvegicus

-

competitive, reversible, strong inhibitor

652999

-

histatin-5

Rattus norvegicus

-

-

652999

-

L-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

L-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

L-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

L-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

L-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

L-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

monopyridinium andrographolide 3alpha,14alpha/beta,19-O-trisuccinate

Homo sapiens

-

-

649658

N-terminal pro-segment of PC7

Rattus norvegicus

-

inhibits its parent enzyme, 50% inhibition at 0.0000004 mM

651961

-

neoandrographolide

Homo sapiens

-

syn: 14-deoxyandrographiside, weak inhibitor, 50% inhibition between 0.5 mM and 2 mM

649658

ZnSO4

Rattus norvegicus

-

94% inhibition at 1 mM

651865

additional information

2 entries

-

14-dehydroandrographolide succinoyl monoester

Homo sapiens

-

-

649658

14-dehydroandrographolide succinoyl monoester

Rattus norvegicus

-

syn: SEA, 0.25 mM

649700

additional information

Homo sapiens

Q16549

no or poor inhibition by decanoyl-RVKR-chloromethylketone

753199

-

additional information

Xenopus laevis

-

the enzyme displays resistance to alpha1-PDX

709057

-