3.4.21.B27: proprotein convertase 7

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For detailed information about proprotein convertase 7, go to the full flat file.

Word Map on EC 3.4.21.B27

3.4.21.B27

furin

tmprss6

endoproteases

pcsks

medicine

pafah1b2

hemochromatosis

furin-like

pnpla3

mbtps1

Reaction

cleaves proteins typically at sites marked by the consensus Arg-Xaa-(Lys/Arg)-Arg sequence =

Synonyms

furin, LPC, lymphoma PC, PC-7, PC7, PC7A, PC7B, PCSK7, Proprotein convertase, proprotein convertase 7, proprotein convertase PCSK7, proprotein convertase subtilisin/kexin type 7, rPC7, S08.077, SPC7, subtilisin-like proprotein convertase 7

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B27 proprotein convertase 7

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Results	in table
1	Activating Compound
6	AA Sequence
4	Application
1	CAS Registry Number
12	Cloned(Commentary)
49	Disease/ Diagnostics
3	Expression
20	General Information
26	Inhibitors
14	Ki Value [mM]
8	KM Value [mM]
27	Localization
3	Metals/Ions
9	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
34	Organism
2	pH Optimum
8	Posttranslational Modification
7	Protein Variants
2	Purification (Commentary)
1	Reaction
18	Reaction Type
34	Reference
40	Source Tissue
48	Substrates and Products (Substrate)
4	Subunits
37	Synonyms
1	Temperature Optimum [°C]

Subunits

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Subunits on EC 3.4.21.B27 - proprotein convertase 7

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3 entries

additional information

Homo sapiens

Q16549

a PLC motif in the cytosolic tail of PC7 is dispensable for endosomal activity, but it is specifically required for trans-Golgi network recycling and to rescue proActivin-A cleavage in Furin-depleted B16-F1 melanoma cells

753199