3.4.21.B27: proprotein convertase 7

This is an abbreviated version!
For detailed information about proprotein convertase 7, go to the full flat file.

Reaction

cleaves proteins typically at sites marked by the consensus Arg-Xaa-(Lys/Arg)-Arg sequence =

Synonyms

furin, LPC, lymphoma PC, PC-7, PC7, PC7A, PC7B, PCSK7, Proprotein convertase, proprotein convertase 7, proprotein convertase PCSK7, proprotein convertase subtilisin/kexin type 7, rPC7, S08.077, SPC7, subtilisin-like proprotein convertase 7

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B27 proprotein convertase 7

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Results	in table
1	Activating Compound
6	AA Sequence
4	Application
1	CAS Registry Number
12	Cloned(Commentary)
49	Disease/ Diagnostics
3	Expression
20	General Information
26	Inhibitors
14	Ki Value [mM]
8	KM Value [mM]
27	Localization
3	Metals/Ions
9	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
34	Organism
2	pH Optimum
8	Posttranslational Modification
7	Protein Variants
2	Purification (Commentary)
1	Reaction
18	Reaction Type
34	Reference
40	Source Tissue
48	Substrates and Products (Substrate)
4	Subunits
37	Synonyms
1	Temperature Optimum [°C]

Posttranslational Modification

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Posttranslational Modification on EC 3.4.21.B27 - proprotein convertase 7

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

glycoprotein

3 entries

lipoprotein

Homo sapiens

Q16549

the enzyme has palmitoylated cysteines, Cys699 and Cys704 within its C-terminus, these posttranslational modifications are not required for transferrin receptor 1 shedding

731888

proteolytic modification

3 entries

side-chain modification

Homo sapiens

-

Cys699 and Cys704 are palmitoylated

717869

glycoprotein

Homo sapiens

-

mature proprotein convertase 7 is partially sulfated, Cys699 and Cys704 are palmitoylated at its cytosolic tail. The enzyme also undergoes N-glycosylation

717835

glycoprotein

Rattus norvegicus

-

zymogen is N-glycosylated

651865

glycoprotein

Rattus norvegicus

-

mature proprotein convertase 7 is partially sulfated, Cys699 and Cys704 are palmitoylated at its cytosolic tail. The enzyme also undergoes N-glycosylation

717835

proteolytic modification

Homo sapiens

Q16549

after autocleavage, proprotein convertases (PCs) exit the endoplasmatic reticulum. They remain bound to their inhibitory cleaved prosegments in latent form until arrival at the cell surface or, in the case of furin, in acidic endosomes, probably to avoid precocious activation or degradation of their substrates. Activated furin can then recycle from endosomes to the trans-Golgi network by binding to specific adaptors in the cytosol

753199

proteolytic modification

Mammalia

-

propeptide is autocatalytically removed during maturation

649651

proteolytic modification

Rattus norvegicus

-

zymogen is processed to mature enzyme in the endoplasmic reticulum

651865