3.4.21.B27: proprotein convertase 7

This is an abbreviated version!
For detailed information about proprotein convertase 7, go to the full flat file.

Reaction

cleaves proteins typically at sites marked by the consensus Arg-Xaa-(Lys/Arg)-Arg sequence =

Synonyms

furin, LPC, lymphoma PC, PC-7, PC7, PC7A, PC7B, PCSK7, Proprotein convertase, proprotein convertase 7, proprotein convertase PCSK7, proprotein convertase subtilisin/kexin type 7, rPC7, S08.077, SPC7, subtilisin-like proprotein convertase 7

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B27 proprotein convertase 7

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Results	in table
1	Activating Compound
6	AA Sequence
4	Application
1	CAS Registry Number
12	Cloned(Commentary)
49	Disease/ Diagnostics
3	Expression
20	General Information
26	Inhibitors
14	Ki Value [mM]
8	KM Value [mM]
27	Localization
3	Metals/Ions
9	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
34	Organism
2	pH Optimum
8	Posttranslational Modification
7	Protein Variants
2	Purification (Commentary)
1	Reaction
18	Reaction Type
34	Reference
40	Source Tissue
48	Substrates and Products (Substrate)
4	Subunits
37	Synonyms
1	Temperature Optimum [°C]

KI Value

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KI Value on EC 3.4.21.B27 - proprotein convertase 7

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0304

14-dehydroandrographolide 3,19-O-disuccinoyl monoester

Homo sapiens

-

-

649658

0.036

andrographolide 3alpha,14beta,19-O-trisuccinate

Homo sapiens

-

-

649658

0.001875

D-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C

682018

0.000081

D-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C

682018

0.000007

EAVLAKHEAVRWHSEQRLLKRAKR

Rattus norvegicus

-

pH 7

649961

0.0024

histatin-3

Rattus norvegicus

-

pH 6.5

652999

-

0.0123

histatin-5

Rattus norvegicus

-

pH 6.5

652999

-

0.006

L-Arg-Arg-Arg-Arg

Homo sapiens

-

in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C

682018

0.0011

L-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C

682018

0.00105

L-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C

682018

0.000312

L-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C

682018

0.0002

L-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C

682018

0.00012

L-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

in 20 mM Bis-Tris, pH 6.5, 1 mM CaCl2, at 37°C

682018

0.026

monopyridinium andrographolide 3alpha,14alpha/beta,19-O-trisuccinate

Homo sapiens

-

-

649658