3.4.21.B27: proprotein convertase 7

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For detailed information about proprotein convertase 7, go to the full flat file.

Reaction

cleaves proteins typically at sites marked by the consensus Arg-Xaa-(Lys/Arg)-Arg sequence =

Synonyms

furin, LPC, lymphoma PC, PC-7, PC7, PC7A, PC7B, PCSK7, Proprotein convertase, proprotein convertase 7, proprotein convertase PCSK7, proprotein convertase subtilisin/kexin type 7, rPC7, S08.077, SPC7, subtilisin-like proprotein convertase 7

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B27 proprotein convertase 7

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Results	in table
1	Activating Compound
6	AA Sequence
4	Application
1	CAS Registry Number
12	Cloned(Commentary)
49	Disease/ Diagnostics
3	Expression
20	General Information
26	Inhibitors
14	Ki Value [mM]
8	KM Value [mM]
27	Localization
3	Metals/Ions
9	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
34	Organism
2	pH Optimum
8	Posttranslational Modification
7	Protein Variants
2	Purification (Commentary)
1	Reaction
18	Reaction Type
34	Reference
40	Source Tissue
48	Substrates and Products (Substrate)
4	Subunits
37	Synonyms
1	Temperature Optimum [°C]

Engineering

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Engineering on EC 3.4.21.B27 - proprotein convertase 7

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

C699A

Homo sapiens

Q16549

site-directed mutagenesis, the mutant activity with substrate transferrin receptor 1 is unaltered compared to the wild-type enzyme

731888

C704A

Homo sapiens

Q16549

site-directed mutagenesis, the mutant activity with substrate transferrin receptor 1 is unaltered compared to the wild-type enzyme

731888

D188G

Homo sapiens

Q16549

site-directed mutagenesis, the autocatalytic processing of the PC7 zymogen is severely impaired leading to accumulation of the inactive pro-enzyme

731888

R316C

Homo sapiens

Q16549

site-directed mutagenesis, the autocatalytic processing of the PC7 zymogen is severely impaired leading to accumulation of the inactive pro-enzyme

731888

additional information

3 entries

additional information

Homo sapiens

Q16549

generation of a frameshift fsL506P enzyme mutant. Construction of an enzyme PC7 chimera, in which the transmembrane domain and the cytosolic tail are replaced by that of the convertase furin, the mutant loses its ability to cleave the transferrin receptor. Identification of the KTECER100;LA cleavage site by site-directed mutagenesis

731888

additional information

Homo sapiens

Q16549

proprotein convertase PC7 can rescue proActivin-A cleavage in furin-depleted B16-F1 melanoma cells

753199

additional information

Mus musculus

-

knockout mice, significant change in the architecture of the thymus and spleen

673911