3.4.21.B27: proprotein convertase 7

This is an abbreviated version!
For detailed information about proprotein convertase 7, go to the full flat file.

Reaction

cleaves proteins typically at sites marked by the consensus Arg-Xaa-(Lys/Arg)-Arg sequence =

Synonyms

furin, LPC, lymphoma PC, PC-7, PC7, PC7A, PC7B, PCSK7, Proprotein convertase, proprotein convertase 7, proprotein convertase PCSK7, proprotein convertase subtilisin/kexin type 7, rPC7, S08.077, SPC7, subtilisin-like proprotein convertase 7

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B27 proprotein convertase 7

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
6	AA Sequence
4	Application
1	CAS Registry Number
12	Cloned(Commentary)
49	Disease/ Diagnostics
3	Expression
20	General Information
26	Inhibitors
14	Ki Value [mM]
8	KM Value [mM]
27	Localization
3	Metals/Ions
9	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
34	Organism
2	pH Optimum
8	Posttranslational Modification
7	Protein Variants
2	Purification (Commentary)
1	Reaction
18	Reaction Type
34	Reference
40	Source Tissue
48	Substrates and Products (Substrate)
4	Subunits
37	Synonyms
1	Temperature Optimum [°C]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 3.4.21.B27 - proprotein convertase 7

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

human transferrin receptor 1 + H2O

?

2 entries

preprohepcidin + H2O

?

Mus musculus

-

key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin

691487

-

-

?

pro-VEGF-C + H2O

VEGF-C + ?

Rattus norvegicus

-

pro-VEGF-C processing is required for VEGF-C induced tumor antiogenesis and lymphangiogenesis

652622

-

652622

?

additional information

?

-

5 entries

human transferrin receptor 1 + H2O

?

Homo sapiens

Q16549

cleavage at an atypical site KTECER-/-LA

731889

-

-

?

human transferrin receptor 1 + H2O

?

Homo sapiens

Q16549

cleavage at an atypical site KTECER-/-LA, in which the P1 Arg100 and P6 Lys95 are critical,.cleavage at Arg100

731888

-

-

?

additional information

?

-

Homo sapiens

-

soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor

717869

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s)

717869

-

-

?

additional information

?

-

Homo sapiens

Q16549

hemojuvelin is not directly cleaved by the enzyme despite the presence of a RNRR motif. No activity on hepcidin

731889

-

-

?

additional information

?

-

Mus musculus

-

soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor

717869

-

-

?

additional information

?

-

Mus musculus

-

the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s)

717869

-

-

?