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Literature summary for 3.4.21.B27 extracted from

  • Rousselet, E.; Benjannet, S.; Marcinkiewicz, E.; Asselin, M.; Lazure, C.; Seidah, N.
    Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor (2011), J. Biol. Chem., 286, 9185-9195.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells, COS-1 cells, and Neuro2A cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-
membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor ?
-
?
additional information Homo sapiens soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor ?
-
?
additional information Mus musculus the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s) ?
-
?
additional information Homo sapiens the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s) ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification Cys699 and Cys704 are palmitoylated Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-
lacrimal gland
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor Mus musculus ?
-
?
additional information soluble proprotein convertase PC7 cannot process wild type epidermal growth factor precursor Homo sapiens ?
-
?
additional information the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s) Mus musculus ?
-
?
additional information the enzyme indirectly induces the processing of membrane-bound and soluble epidermal growth factor precursor into an about 115 kDa transmembrane form (EGF-115) at the VHPR290 motif. The production of EGF-115 is most probably achieved via the activation by PC7 of a latent serine and/or cysteine protease(s) Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PC7
-
Mus musculus
PC7
-
Homo sapiens

General Information

General Information Comment Organism
physiological function proprotein convertase PC7 enhances the activation of the epidermal growth factor receptor pathway through processing of the epidermal growth factor precursor Mus musculus
physiological function proprotein convertase PC7 enhances the activation of the epidermal growth factor receptor pathway through processing of the epidermal growth factor precursor Homo sapiens