3.4.21.B27: proprotein convertase 7
This is an abbreviated version!
For detailed information about proprotein convertase 7, go to the full flat file.
Word Map on EC 3.4.21.B27
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3.4.21.B27
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furin
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tmprss6
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endoproteases
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pcsks
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medicine
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pafah1b2
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hemochromatosis
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furin-like
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pnpla3
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mbtps1
- 3.4.21.B27
- furin
- tmprss6
- endoproteases
-
pcsks
- medicine
- pafah1b2
- hemochromatosis
-
furin-like
-
pnpla3
-
mbtps1
Reaction
cleaves proteins typically at sites marked by the consensus Arg-Xaa-(Lys/Arg)-Arg sequence =
Synonyms
furin, LPC, lymphoma PC, PC-7, PC7, PC7A, PC7B, PCSK7, Proprotein convertase, proprotein convertase 7, proprotein convertase PCSK7, proprotein convertase subtilisin/kexin type 7, rPC7, S08.077, SPC7, subtilisin-like proprotein convertase 7
ECTree
3.4.21.B27 proprotein convertase 7Advanced search results
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results (Localization
Localization on EC 3.4.21.B27 - proprotein convertase 7
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LOCALIZATION 
ORGANISM
UNIPROT
COMMENTARY 
GeneOntology No.
LITERATURE
SOURCE
only overexpressed PC7 activity reaches the cell surface, endosomes, and the trans-Golgi network
additional information
complementary subcellular distribution of bioactive furin and proprotein convertase PC7. Furin activity in endosomes is 10fold less inhibited by decanoyl-RVKR-chloromethylketone and enriched over 3fold in endosomes compared to the trans-Golgi network. Development of targeted compartment-specific biosensors. Endogenous PC7, which resists the inhibitor, is active in distinct vesicles. Overexpressed PC7 cleaves trans-Golgi network/endosomal CLIP v.4 variants
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only overexpressed PC7 activity reaches the cell surface, endosomes, and the trans-Golgi network
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active enzyme, proprotein convertase reaches the cell surface by a non-conventional secretory pathway through a brefeldin A- and COPII-coated vesicles independent way
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active enzyme, proprotein convertase reaches the cell surface by a non-conventional secretory pathway through a brefeldin A- and COPII-coated vesicles independent way
the enzyme is concentrated in the trans-Golgi network but it shuttles between the plasma membrane and the trans-Golgi network depending on sequences in the cytoplasmic tail. A short region containing a three amino acids motif, P724-L725-C726, is essential and sufficient for internalization of PC7 but not for trans-Golgi network localization, which requires the additional presence of the juxtamembrane region. Endosome to trans-Golgi network transport of proprotein convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteinesA motif
only overexpressed PC7 activity reaches the cell surface, endosomes, and the trans-Golgi network. A PLC motif in the cytosolic tail of the enzyme is dispensable for endosomal activity, but it is specifically required for trans-Golgi network recycling
the enzyme is concentrated in the trans-Golgi network but it shuttles between the plasma membrane and the trans-Golgi network depending on sequences in the cytoplasmic tail. A short region containing a three amino acids motif, P724-L725-C726, is essential and sufficient for internalization of PC7 but not for trans-Golgi network localization, which requires the additional presence of the juxtamembrane region
