3.4.21.B27: proprotein convertase 7

This is an abbreviated version!
For detailed information about proprotein convertase 7, go to the full flat file.

Reaction

cleaves proteins typically at sites marked by the consensus Arg-Xaa-(Lys/Arg)-Arg sequence =

Synonyms

furin, LPC, lymphoma PC, PC-7, PC7, PC7A, PC7B, PCSK7, Proprotein convertase, proprotein convertase 7, proprotein convertase PCSK7, proprotein convertase subtilisin/kexin type 7, rPC7, S08.077, SPC7, subtilisin-like proprotein convertase 7

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B27 proprotein convertase 7

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Results	in table
1	Activating Compound
6	AA Sequence
4	Application
1	CAS Registry Number
12	Cloned(Commentary)
49	Disease/ Diagnostics
3	Expression
20	General Information
26	Inhibitors
14	Ki Value [mM]
8	KM Value [mM]
27	Localization
3	Metals/Ions
9	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
34	Organism
2	pH Optimum
8	Posttranslational Modification
7	Protein Variants
2	Purification (Commentary)
1	Reaction
18	Reaction Type
34	Reference
40	Source Tissue
48	Substrates and Products (Substrate)
4	Subunits
37	Synonyms
1	Temperature Optimum [°C]

Disease

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Disease on EC 3.4.21.B27 - proprotein convertase 7

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Breast Neoplasms

Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression.

32820145

Dyslipidemias

Network Medicine Approach in Prevention and Personalized Treatment of Dyslipidemias.

33118184

Dyslipidemias

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients.

30918065

Hemochromatosis

Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis.

24556216

Hemochromatosis

Proprotein convertase 7 rs236918 is associated with liver fibrosis in Italian patients with HFE-related Hemochromatosis.

26868056

Hemochromatosis

Variants in PCSK7, PNPLA3 and TM6SF2 are risk factors for the development of cirrhosis in hereditary haemochromatosis.

33565643

Hypercholesterolemia

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients.

30918065

Hypertriglyceridemia

Building bridges: PCSK7 as a NAFLD candidate gene connecting hepatic inflammation with hypertriglyceridemia.

31023721

Insulin Resistance

PCSK7 Genotype Modifies Effect of a Weight-Loss Diet on 2-Year Changes of Insulin Resistance: The POUNDS LOST Trial.

25504030

Iron Overload

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients.

30918065

Liver Cirrhosis

Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis.

24556216

Liver Cirrhosis

PNPLA3 and RNF7 Gene Variants are Associated with the Risk of Developing Liver Fibrosis and Cirrhosis in an Eastern European Population.

28338112

Liver Cirrhosis

Proprotein convertase 7 rs236918 is associated with liver fibrosis in Italian patients with HFE-related Hemochromatosis.

26868056

Liver Diseases

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients.

30918065

Neoplasms

Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.

23409034

Non-alcoholic Fatty Liver Disease

Building bridges: PCSK7 as a NAFLD candidate gene connecting hepatic inflammation with hypertriglyceridemia.

31023721

Non-alcoholic Fatty Liver Disease

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients.

30918065

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