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3.1.8.1: aryldialkylphosphatase

This is an abbreviated version!
For detailed information about aryldialkylphosphatase, go to the full flat file.

Word Map on EC 3.1.8.1

Reaction

An aryl dialkyl phosphate
+
H2O
=
dialkyl phosphate
 +
an aryl alcohol

Synonyms

A-esterase, A7Q26_23485, aminopeptidase P, AMPP, aryldialkylphosphatase, arylesterase, aryltriphosphatase, bacterial phosphotriesterase, DFPase, diisopropyl fluorophosphatase, esterase B1, esterase E4, esterase, organophosphate, esterase, paraoxon, esterase, pirimiphos-methyloxon, G3C9 rePON1, h-PON1, HAD, haloalkylphosphorus hydrolase, HDL-associated esterase/lactonase paraoxonase 1, HDL-PON1, high activity paraoxonase, high-density lipoprotein-associated esterase/lactonase, human paraoxonase 1, HuPON1, inner membrane protein YiaH, lactonase SsoPox, lactonase/phosphotriesterase, low activity paraoxonase, methyl parathion hydrolase, More, Mph, mPHP, OP hydrolase, OP-hydrolase, OP-hydrolyzing enzyme, OPA anhydrase, opd, OpdA, OpdD, OPH, OPHC2, organophosphate hydrolase, organophosphorous hydrolase, organophosphorus acid anhydrase, organophosphorus hydrolase, organophosphorus pesticide hydrolase, organophosphorus-hydrolyzing enzyme, paraoxon hydrolase, paraoxonase, paraoxonase 1, paraoxonase 1A, paraoxonase 3, paraoxonase-1, paraoxonase-2, paraoxonase1, parathion hydrolase, phosphotriesterase, phosphotriesterase homology protein, phosphotriesterase-like lactonase, PHP, pirimiphos-methyloxon esterase, PLL, PO.ase, PON, PON 1, PON-1, PON-aryl, PON-para, PON1, PON1A, PON2, PON3, POX, PTE, PTE S5, Rv0230c, SACI2140, Saci_2140, SacPox, Sb-PTE, serum paraoxonase, serum paraoxonase 1, SisLac, SisPox, Sso, SSO2522, SsoPox, type A paraoxonase, type B paraoxonase, VmoLac, Vmut2255, VmutPLL

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.8 Phosphoric-triester hydrolases
                3.1.8.1 aryldialkylphosphatase

KCat KM Value

KCat KM Value on EC 3.1.8.1 - aryldialkylphosphatase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
9.43
(1E)-but-1-en-1-yl dibutyl phosphate
pH 9.0, 25°C
1.264 - 85
(S)-[2-[di(propan-2-yl)amino]ethyl] O,O-diethyl phosphorothioate
0.003 - 2.3
4-acetylphenyl (2R)-3,3-dimethylbutan-2-yl (R)-methylphosphonate
0.016 - 0.59
4-acetylphenyl (2R)-3,3-dimethylbutan-2-yl (S)-methylphosphonate
0.0011 - 1.7
4-acetylphenyl (2S)-3,3-dimethylbutan-2-yl (S)-methylphosphonate
21.4 - 333.3
4-acetylphenyl (R)-2-methylpropyl methylphosphonate
5.55 - 883.3
4-acetylphenyl (S)-2-methylpropyl methylphosphonate
1.5 - 850
4-acetylphenyl 2-methylpropyl (R)-methylphosphonate
0.099 - 180
4-acetylphenyl 2-methylpropyl (S)-methylphosphonate
0.25 - 28
4-acetylphenyl cyclohexyl (R)-methylphosphonate
0.00094 - 28
4-acetylphenyl cyclohexyl (S)-methylphosphonate
1.16
4-acetylphenyl cyclohexyl methyl (R)-phosphate
pH 8.5, 30°C
3.17
4-acetylphenyl cyclohexyl methyl (S)-phosphate
pH 8.5, 30°C
1.5 - 520
4-acetylphenyl ethyl (R)-methylphosphonate
130 - 1200
4-acetylphenyl ethyl (S)-methylphosphonate
1.8 - 580
4-acetylphenyl propan-2-yl (R)-methylphosphonate
3.1 - 110
4-acetylphenyl propan-2-yl (S)-methylphosphonate
1.45
4-carbamoylphenyl diethyl phosphate
pH and temperature not specified in the publication
0.438
CMP-coumarin
pH 8.3, 25°C
42.37
cyclohexyl ethyl 4-nitrophenyl (R)-phosphate
pH 8.5, 30°C
51.85
cyclohexyl ethyl 4-nitrophenyl (S)-phosphate
pH 8.5, 30°C
5.45
cyclohexyl methyl 4-nitrophenyl (R)-phosphate
pH 8.5, 30°C
20.94
cyclohexyl methyl 4-nitrophenyl (S)-phosphate
pH 8.5, 30°C
63.33
cyclohexyl methyl phenyl (R)-phosphate
pH 8.5, 30°C
0.00083
cyclosarin
-
in 50 mM Tris-HCl buffer, 10 mM CaCl2, pH 7.4
0.0000983
demeton-S
-
at 35°C, pH 7.2
1.63 - 40.23
demeton-S methyl
0.9 - 3.27
dibutyl 2,2,3,3-tetrafluorobutyl phosphate
0.25
dibutyl 3,3-difluorobutyl phosphate
pH 9.0, 25°C
5.81
dibutyl 4-acetophenyl phosphate
pH and temperature not specified in the publication
50
dibutyl 4-nitrophenyl phosphate
pH and temperature not specified in the publication
31.4
dibutyl phenyl phosphate
pH and temperature not specified in the publication
1.1
dichlorvos
pH 8.0, 37°C, enzyme administered in monkeys in vivo
74.7
diethyl 2,4,6-trifluorophenyl phosphate
pH and temperature not specified in the publication
33.3
diethyl 2,4-difluorophenyl phosphate
pH and temperature not specified in the publication
84.54
diethyl 2,6-difluoro-4-nitrophenyl phosphate
pH and temperature not specified in the publication
63.5
diethyl 2-fluoro-4-nitrophenyl phosphate
pH and temperature not specified in the publication
16.15
diethyl 2-fluorophenyl phosphate
pH and temperature not specified in the publication
428
diethyl 3-fluoro-4-nitrophenyl phosphate
pH and temperature not specified in the publication
300
diethyl 3-fluorophenyl phosphate
pH and temperature not specified in the publication
2.5
diethyl 4-acetophenyl phosphate
pH and temperature not specified in the publication
97.6
diethyl 4-chlorophenyl phosphate
pH and temperature not specified in the publication
138.8
diethyl 4-cyanophenyl phosphate
pH and temperature not specified in the publication
48.75
diethyl 4-fluorophenyl phosphate
pH and temperature not specified in the publication
25.8
diethyl 4-formylphenyl phosphate
pH and temperature not specified in the publication
5.68
diethyl 4-methoxyphenyl phosphate
pH and temperature not specified in the publication
0.91 - 100
diethyl 4-nitrophenyl phosphate
1.8 - 7.3
diethyl paraoxon
363.04
diethyl pentafluoro-phenyl phosphate
pH and temperature not specified in the publication
64.54
diethyl phenyl phosphate
pH and temperature not specified in the publication
0.2 - 27531
diethyl-paraoxon
151.16
diethylumbelliferyl phosphate
-
pH 7.5, 25°C, recombinant mutant enzyme G137D
11.97
dimethyl 4-nitrophenyl phosphate
pH 8.5, 30°C
0.11 - 11.89
dimethyl-paraoxon
0.05467 - 25
ethyl paraoxon
0.00186
ethyl-paraoxon
pH 8.0, 70°C
0.0056 - 154.9
malathion
103.28
methyl 4-nitrophenyl phenyl (R)-phosphate
pH 8.5, 30°C
2.4
methyl 4-nitrophenyl phenyl (S)-phosphate
pH 8.5, 30°C
2.17
methyl 4-nitrophenyl propan-2-yl (R)-phosphate
pH 8.5, 30°C
56.94
methyl 4-nitrophenyl propan-2-yl (S)-phosphate
pH 8.5, 30°C
3.2
methyl 4-[(diethoxyphosphoryl)oxy]benzoate
pH and temperature not specified in the publication
112.5
methyl bis(4-nitrophenyl) phosphate
pH 8.5, 30°C
0.029 - 102
methyl paraoxon
0.0091 - 0.036
methyl parathion
4.94
O,O,S-tributyl phosphorothioate
pH 9.0, 25°C
0.867
O,O-diethyl fluorophosphate
-
pH 8.0, 25°C, enzyme administered in mice in vivo
0.2
O-ethyl-S-[2-(diisopropylamino)ethyl]-methylphosphonothioic acid
-
in 50 mM Tris-HCl buffer, 10 mM CaCl2, pH 7.4
0.2
O-isobutyl-S-[2-(diethylamino)ethyl]methylphosphonothioic acid
-
in 50 mM Tris-HCl buffer, 10 mM CaCl2, pH 7.4
0.02167 - 10000
paraoxon
0.281 - 1.1
parathion
617 - 767
RP-O-ethyl methylphosphonyl-3-cyano-7-hydroxy-4-methylcoumarin
883 - 933
RP-O-n-propyl methylphosphonyl-3-cyano-7-hydroxy-4-methylcoumarin
0.00486 - 0.0249
S-(2-[di(propan-2-yl)amino]ethyl)O-ethyl methylphosphonothioate
0.283
SP-CMP
pH 8.0, 25°C, enzyme administered in mice in vivo
1.05 - 6.7
SP-O-ethyl methylphosphonyl-3-cyano-7-hydroxy-4-methylcoumarin
13.6 - 25
SP-O-n-propyl methylphosphonyl-3-cyano-7-hydroxy-4-methylcoumarin
0.767
Tabun
-
pH 8.0, 25°C, enzyme administered in mice in vivo