3.1.8.1: aryldialkylphosphatase
This is an abbreviated version!
For detailed information about aryldialkylphosphatase, go to the full flat file.
Word Map on EC 3.1.8.1
-
3.1.8.1
-
arylesterase
-
paraoxonase-1
-
cholesterol
-
nerve
-
atherosclerosis
-
cardiovascular
-
low-density
-
insecticide
-
triglyceride
-
coronary
-
apolipoproteins
-
acetylcholinesterase
-
malondialdehyde
-
diminuta
-
poison
-
soman
-
p-nitrophenol
-
warfare
-
sarin
-
bioremediation
-
chlorpyrifos
-
vx
-
antiatherogenic
-
decontamination
-
bioscavenger
-
atherogenesis
-
cholinesterase
-
phenylacetate
-
medicine
-
binuclear
-
phosphotriesters
-
atherogenic
-
flavobacterium
-
carboxylesterase
-
hdl-cholesterol
-
apoa-i
-
butyrylcholinesterase
-
fluorophosphate
-
surface-expressed
-
diazoxon
-
tabun
-
thiolactone
-
g-type
-
salt-stimulated
-
triesters
-
malathion
-
ochrobactrum
-
sphingobium
-
radiobacter
-
cyclosarin
-
loligo
-
synthesis
-
environmental protection
-
drug development
-
degradation
-
biotechnology
-
diagnostics
-
agriculture
-
analysis
-
nutrition
- 3.1.8.1
- arylesterase
- paraoxonase-1
- cholesterol
- nerve
- atherosclerosis
- cardiovascular
-
low-density
-
insecticide
- triglyceride
- coronary
-
apolipoproteins
- acetylcholinesterase
- malondialdehyde
- diminuta
-
poison
- soman
- p-nitrophenol
-
warfare
- sarin
-
bioremediation
- chlorpyrifos
- vx
-
antiatherogenic
-
decontamination
-
bioscavenger
- atherogenesis
- cholinesterase
- phenylacetate
- medicine
-
binuclear
-
phosphotriesters
-
atherogenic
- flavobacterium
- carboxylesterase
-
hdl-cholesterol
- apoa-i
- butyrylcholinesterase
- fluorophosphate
-
surface-expressed
- diazoxon
- tabun
-
thiolactone
-
g-type
-
salt-stimulated
-
triesters
- malathion
- ochrobactrum
- sphingobium
- radiobacter
- cyclosarin
-
loligo
- synthesis
- environmental protection
- drug development
- degradation
- biotechnology
- diagnostics
- agriculture
- analysis
- nutrition
Reaction
Synonyms
A-esterase, A7Q26_23485, aminopeptidase P, AMPP, aryldialkylphosphatase, arylesterase, aryltriphosphatase, bacterial phosphotriesterase, DFPase, diisopropyl fluorophosphatase, esterase B1, esterase E4, esterase, organophosphate, esterase, paraoxon, esterase, pirimiphos-methyloxon, G3C9 rePON1, h-PON1, HAD, haloalkylphosphorus hydrolase, HDL-associated esterase/lactonase paraoxonase 1, HDL-PON1, high activity paraoxonase, high-density lipoprotein-associated esterase/lactonase, human paraoxonase 1, HuPON1, inner membrane protein YiaH, lactonase SsoPox, lactonase/phosphotriesterase, low activity paraoxonase, methyl parathion hydrolase, More, Mph, mPHP, OP hydrolase, OP-hydrolase, OP-hydrolyzing enzyme, OPA anhydrase, opd, OpdA, OpdD, OPH, OPHC2, organophosphate hydrolase, organophosphorous hydrolase, organophosphorus acid anhydrase, organophosphorus hydrolase, organophosphorus pesticide hydrolase, organophosphorus-hydrolyzing enzyme, paraoxon hydrolase, paraoxonase, paraoxonase 1, paraoxonase 1A, paraoxonase 3, paraoxonase-1, paraoxonase-2, paraoxonase1, parathion hydrolase, phosphotriesterase, phosphotriesterase homology protein, phosphotriesterase-like lactonase, PHP, pirimiphos-methyloxon esterase, PLL, PO.ase, PON, PON 1, PON-1, PON-aryl, PON-para, PON1, PON1A, PON2, PON3, POX, PTE, PTE S5, Rv0230c, SACI2140, Saci_2140, SacPox, Sb-PTE, serum paraoxonase, serum paraoxonase 1, SisLac, SisPox, Sso, SSO2522, SsoPox, type A paraoxonase, type B paraoxonase, VmoLac, Vmut2255, VmutPLL
ECTree
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Natural Substrates Products on EC 3.1.8.1 - aryldialkylphosphatase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-[fluoro(methyl)phosphoryl]oxy-2,2-dimethylbutane + H2O
?
i.e. soman
-
-
?
chlorpyrifos oxon + H2O
diethyl phosphate + 3,5,6-trichloropyridin-2-ol
-
-
-
?
cyclohexylmethylphosphonofluoridate + H2O
?
i.e. cyclosarin
-
-
?
dichlorvos + H2O
2,2-dichloroethenol + dimethyl hydrogen phosphate
-
-
-
?
dyfonate + H2O
O,O-diethylphosphorothioate + 2-isopropyl-6-methylpyrimidin-4-ol
-
-
-
-
?
methyl-parathion + H2O
dimethyl thiophosphate + 4-nitrophenol
-
-
-
?
O,O-diethyl fluorophosphate + H2O
diethylphosphate + fluoride
-
activity of EC 3.1.8.2
-
-
?
O-isobutyl-S-(2-diethylaminoethyl)methylphosphonothiolate + H2O
?
i.e. RVX, VR, or Russian VX
-
-
?
SP-CMP + H2O
?
SP-CMP is the toxic SP enantiomer of a cyclosarin surrogate in which the fluoride leaving group is replaced by a coumarin derivative
-
-
?
chlorpyrifos + H2O
O,O-diethylphosphorothioate + 3,5,6-trichloropyridin-2-ol
-
-
-
-
?
chlorpyrifos + H2O
O,O-diethylphosphorothioate + 3,5,6-trichloropyridin-2-ol
Latilactobacillus sakei WCP904
-
-
-
-
?
coumaphos + H2O
O,O-diethylphosphorothioate + 3-chloro-4-methylumbelliferone
-
-
-
-
?
coumaphos + H2O
O,O-diethylphosphorothioate + 3-chloro-4-methylumbelliferone
Latilactobacillus sakei WCP904
-
-
-
-
?
diethyl-paraoxon + H2O
diethyl phosphate + 4-nitrophenol
-
-
-
?
diethyl-paraoxon + H2O
diethyl phosphate + 4-nitrophenol
-
-
-
?
diethyl-paraoxon + H2O
diethyl phosphate + 4-nitrophenol
-
-
-
?
diethyl-paraoxon + H2O
diethyl phosphate + 4-nitrophenol
-
-
-
?
diethyl-paraoxon + H2O
diethyl phosphate + 4-nitrophenol
-
-
-
?
diethyl-paraoxon + H2O
diethyl phosphate + 4-nitrophenol
-
-
-
?
diethyl-paraoxon + H2O
diethyl phosphate + 4-nitrophenol
-
-
-
?
diethyl-paraoxon + H2O
diethyl phosphate + 4-nitrophenol
-
-
-
?
diethyl-parathion + H2O
diethyl thiophosphate + 4-nitrophenol
-
-
-
-
?
diethyl-parathion + H2O
diethyl thiophosphate + 4-nitrophenol
-
-
-
?
diethyl-parathion + H2O
diethyl thiophosphate + 4-nitrophenol
-
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
-
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
-
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
Nocardia asteroides ATCC 19296
-
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
-
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
-
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
-
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
Pseudarthrobacter oxydans ATCC 14359
-
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
-
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
-
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
-
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
-
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
-
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
-
fluorimetric detection on solid medium
-
-
?
dimethyl-paraoxon + H2O
dimethyl phosphate + 4-nitrophenol
Streptomyces phaeochromogenes CCRC 10811
-
fluorimetric detection on solid medium
-
-
?
dimethyl-parathion + H2O
dimethyl thiophosphate + 4-nitrophenol
-
-
-
?
dimethyl-parathion + H2O
dimethyl thiophosphate + 4-nitrophenol
-
-
-
-
?
dimethyl-parathion + H2O
dimethyl thiophosphate + 4-nitrophenol
-
-
-
?
dimethyl-parathion + H2O
dimethyl thiophosphate + 4-nitrophenol
-
-
-
?
O-ethyl-S-(2-diisopropylaminoethyl)methylphosphonothiolate + H2O
?
i.e. VX
-
-
?
O-ethyl-S-(2-diisopropylaminoethyl)methylphosphonothiolate + H2O
?
i.e. VX
-
-
?
parathion + H2O
diethyl thiophosphate + 4-nitrophenol
-
-
-
?
additional information
?
-
the enzyme is involved in detoxification of a broad range of organophosphorus pesticides and chemical warfare agents sarin and VX
-
-
?
additional information
?
-
-
isozyme PON2 has antioxidant properties, prevents low density lipoprotein lipid peroxidation and reverses the oxidation of mildly oxidized low density lipoproteins
-
-
?
additional information
?
-
-
PON1 is involved in metabolism of oxidized lipid compounds
-
-
?
additional information
?
-
-
isozyme PON1 is effective at reducing the activity of phospholipid oxidation products
-
-
?
additional information
?
-
-
the enzyme PON2 has antioxidant properties, prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of mildly oxidized LDL to induce monocyte chemotaxis
-
?
additional information
?
-
-
HDL-associated enzyme is a cardio- and vasoprotective enzyme
-
-
?
additional information
?
-
-
the enzyme associated to high-density lipoproteins HDL exhibits antioxidant function of particular physiological relevance, mechanism, compositional fluctuations of HDL effects the influence of the enzyme on cardiovascular risks, overview, PON1 content is reduced in human ApoAI deficiency disease
-
-
?
additional information
?
-
-
the enzyme efficiently hydrolyzes organophosphorus nerve agents
-
-
?
additional information
?
-
-
the enzyme is important in detoxification of organophosphorus compounds, structure and applications of organophosphorus compounds, clinical evidence of PON1, overview
-
-
?
additional information
?
-
the serum paraoxonase family contains detoxifying and anti-atherosclerotic enzymes
-
-
?
additional information
?
-
polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview
-
-
?
additional information
?
-
-
polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview
-
-
?
additional information
?
-
-
PON1 has a protective role e.g. against organophosphorous poisoning, but also against vascular diseases, PON1 has an anti-atherogenic activity
-
-
?
additional information
?
-
PON1 hydrolyses esters, including organophosphates and lactones, and exhibits anti-atherogenic properties, the enzyme is associated to high-density-lipoprotein, bound together with the human phosphate binding protein
-
-
?
additional information
?
-
-
PON1 is a high-density lipoprotein-associated enzyme capable of hydrolyzing diverse substrates from organophosphate toxins to oxidized phospholipids, PON1 is linked with both the prevention of organophosphate poisoning and inhibition of atherosclerosis initiated by oxidatively modified low-density lipoprotein, overview, phenotypic distribution of the enzyme in individuals of both sexes and different age, overview
-
-
?
additional information
?
-
-
the enzyme depends on high-density lipoprotein HDL as carrier and site of action, PON1 acts as an antioxidant preventing low-density lipoprotein peroxidation, overview
-
-
?
additional information
?
-
-
high-density lipoprotein-associated paraoxonase possesses peroxidase-like activity that can contribute to the protective effect of paraoxonase against lipoprotein oxidation. The presence of paraoxonase in high-density lipoprotein may thus be a major contributor to the antiatherogenicity of this lipoprotein
-
-
?
additional information
?
-
PON1 hydrolyzes organophosphates, such as paraoxon, aromatic esters, for instance, phenyl acetate, and also lipid peroxidation products, and reduces the accumulation of them, PON1 prevents the acceleration of atherosclerosis, exhibits antioxidant ability, and assumes an antiatherogenic property. Negative correlation between the activity of PON1 and the level of lipid hydroperoxides in the rheumatoid arthritis patient group, overview
-
-
?
additional information
?
-
PON1 is a lipolactonase that associates with HDL-apolipoprotein A-I and thereby plays a role in the prevention of atherosclerosis
-
-
?
additional information
?
-
-
PON1 is a lipolactonase that associates with HDL-apolipoprotein A-I and thereby plays a role in the prevention of atherosclerosis
-
-
?
additional information
?
-
PON1 is not able to prevent macrophage oxidative stress, however, is able to retard macrophage-induced low-density lipoprotein oxidation
-
-
?
additional information
?
-
PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products
-
-
?
additional information
?
-
-
PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products
-
-
?
additional information
?
-
the active site of PON1 is characterized by two distinct binding regions, the hydrophobic binding site for arylesters/lactones and the paraoxon binding site for phosphotriesters
-
-
?
additional information
?
-
-
the active site of PON1 is characterized by two distinct binding regions, the hydrophobic binding site for arylesters/lactones and the paraoxon binding site for phosphotriesters
-
-
?
additional information
?
-
the enzyme carried by high-density lipoprotein, exerts a protective effect against oxidative damage of cells and lipoproteins, modulating the susceptibility of high-density lipoprotein to atherogenic modifications and has an anti-inflammatory role, low PON1 activity is a risk factor for cardiovascular disease
-
-
?
additional information
?
-
the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview
-
-
?
additional information
?
-
the overall substrate preference of cAMPP is methylphosphonates > ethylphosphonates >/= organophosphates
-
-
?
additional information
?
-
-
the enzyme associated to high-density lipoproteins HDL exhibits antioxidant function of particular physiological relevance, mechanism, compositional fluctuations of HDL effects the influence of the enzyme on cardiovascular risks, overview
-
-
?
additional information
?
-
-
improved degradation of organophosphorus pesticides by the engineered cell surface-expressed PON1 of transformeted strain JS444
-
-
?
additional information
?
-
-
improved degradation of organophosphorus pesticides by the engineered cell surface-expressed PON1 of transformeted strain JS444
-
-
?
additional information
?
-
the phosphotriesterase-like lactonase enzyme is bifunctional showing lactonase (EC 3.1.1.81) and phosphotriesterase (EC 3.1.8.1 and 3.1.8.2) activities
-
-
?
additional information
?
-
organophosphate hydrolase interacts with Ton components and is targeted to the membrane only in the presence of the ExbB/ExbD complex
-
-
?
additional information
?
-
-
organophosphate hydrolase interacts with Ton components and is targeted to the membrane only in the presence of the ExbB/ExbD complex
-
-
?
additional information
?
-
phosphotriesterase from Sphingobium sp. TCM1 (Sb-PTE) possesses a rather broad substrate profile and is able to hydrolyze insecticides, plasticizers, and flame retardants that are not typically substrates for other enzymes of this class
-
-
?
