Reference on EC 3.1.8.1 - aryldialkylphosphatase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mackness, M.I.; Walker, C.H.
Multiple forms of sheep serum A-esterase activity associated with the high-density lipoprotein
Biochem. J.
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539-545
1988
Ovis aries
Gonzalo, M.C.; Gil, F.; Hernandez, A.F.; Rodrigo, L.; Villanueva, E.; Pla, A.
Human liver paraoxonase (PON1): subcellular distribution and characterization
J. Biochem. Mol. Toxicol.
12
61-69
1998
Homo sapiens
Reiner, E.; Simeon-Rudolf, V.; Skrinjaric-Spoljar, M.
Catalytic properties and distribution profiles of paraoxonase and cholinesterase phenotypes in human sera
Toxicol. Lett.
82/83
447-452
1995
Homo sapiens
Aviram, M.; Rosenblatt, M.; Bisgaier, C.L.; Newton, R.S.; Primo-Parmo, S.L.; La Du, B.N.
Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase
J. Clin. Invest.
101
1581-1590
1998
Homo sapiens
Gil, F.; Pla, A.; Gonzalvo, M.C.; Hernandez, A.F.; Villanueva, E.
Rat liver paraoxonase: subcellular distribution and characterization
Chem. Biol. Interact.
87
149-154
1993
Rattus norvegicus
Hernandez, A.F.; Pla, A.; Valenzuela, A.; Gil, F.; Villanueva, E.
Characterization of paraoxonase activity in pericardial fluid: usefulness as a marker of coronary disease
Chem. Biol. Interact.
87
173-177
1993
Homo sapiens
Gan, K.N.; Smolen, A.; Eckerson, H.W.; La Du, B.N.
Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities
Drug Metab. Dispos.
19
100-106
1991
Homo sapiens
Smolen, A.; Eckerson, H.W.; Gan, K.N.; Hailat, N.; La Du, B.N.
Characteristics of the genetically determined allozymic forms of human serum paraoxonase/arylesterase
Drug Metab. Dispos.
19
107-112
1991
Homo sapiens
Huang, Y.S.; Woods, L.; Sultatos, L.G.
Solubilization and purification of A-esterase from mouse hepatic microsomes
Biochem. Pharmacol.
48
1273-1280
1994
Mus musculus
Haagen, L.; Brock, A.
A new automated method for phenotyping arylesterase (EC 3.1.1.2) based upon inhibition of enzymatic hydrolysis of 4-nitrophenyl acetate by phenyl acetate
Eur. J. Clin. Chem. Clin. Biochem.
30
391-395
1992
Homo sapiens
Nishio, E.; Watanabe, Y.
Cigarette smoke extract inhibits plasma paraoxonase activity by modification of the enzyme s free thiols
Biochem. Biophys. Res. Commun.
236
289-293
1997
Homo sapiens
Pond, A.L.; Chambers, H.W.; Coyne, C.P.; Chamers, J.E.
Purification of two rat hepatic proteins with A-esterase activity toward chlorpyrifos-oxon and paraoxon
J. Pharmacol. Exp. Ther.
286
1404-1411
1998
Rattus norvegicus
Tanaka-Kawai, H.; Yomoda, S.
Molecular weight and substrate characteristics of human serum arylesterase following purification by immuno-affinity chromatography
Clin. Chim. Acta
215
127-138
1993
Homo sapiens
Furlong, C.E.; Richter, R.J.; Chapline, C.; Crabb, J.W.
Purification of rabbit and human serum paraoxonase
Biochemistry
30
10133-10140
1991
Oryctolagus cuniculus, Homo sapiens
Mackness, M.I.; Thompson, H.M.; Hardy, A.R.; Walker, C.H.
Distinction between A-esterases and arylesterases. Implications for esterase classification
Biochem. J.
245
293-296
1987
Bos taurus, Felis catus, Homo sapiens, Hydrochoerus hydrochaeris, Meles taxus, Mus musculus, no activity in aves, Rattus norvegicus, Sus scrofa
Dave, K.I.; Miller, C.E.; Wild, J.R.
Characterization of organophosphorus hydrolases and the genetic manipulation of the phosphotriesterase from Pseudomonas diminuta
Chem. Biol. Interact.
87
55-68
1993
Flavobacterium sp.
Mackness, M.I.; Arrol, S.; Durrington, P.N.
Substrate specificity of human serum paraoxonase
Biochem. Soc. Trans.
19
304S
1991
Homo sapiens
Lai, K.; Dave, K.I.; Wild, J.R.
Bimetallic binding motifs in organophosphorus hydrolase are important for catalysis and structural organization
J. Biol. Chem.
269
16579-16584
1994
Escherichia coli
Hassett, C.; Richter, R.J.; Humbert, R.; Chapline, C.; Crabb, J.W.; Omiecinski, C.J.; Furlong, C.E.
Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence
Biochemistry
30
10141-10149
1991
Oryctolagus cuniculus, Homo sapiens
Gil, F.; Gonzalvo, M.C.; Hernandez, A.F.; Villanueva, E.; Antonio, P.
Differences in the kinetic properties, effect of calcium and sensitivity to inhibitors of paraoxon hydrolase activity in rat plasma and microsomal fraction from rat liver
Biochem. Pharmacol.
48
1559-1568
1994
Rattus norvegicus
La Du, B.N.; Adkins, S.; Kuo, C.L.; Lipsig, D.
Studies on human serum paraoxonase/arylesterase
Chem. Biol. Interact.
87
25-34
1993
Homo sapiens
Gil, F.; Pla, A.; Gonzalco, M.C.; Hernandez, A.F.; Villanueva, E.
Partial purification of paraoxonase from rat liver
Chem. Biol. Interact.
87
69-75
1993
Rattus norvegicus
Pellin, M.C.; Moretto, A.; Lotti, M.; Vilanova, E.
Distribution and some biochemical properties of rat paraoxonase activity
Neurotoxicol. Teratol.
12
611-614
1990
Homo sapiens, Rattus norvegicus
Little, J.S.; Broomfield, C.A.; Fox-Talbot, M.K.; Boucher, L.J.; MacIver, B.; Lenz, D.E.
Partial characterization of an enzyme that hydrolyzes sarin, soman, tabun, and diisopropyl phosphorofluoridate (DFP)
Biochem. Pharmacol.
38
23-29
1989
Rattus norvegicus
Dumas, D.P.; Durst, H.D.; Landis, W.G.; Raushel, F.M.; Wild, J.R.
Inactivation of organophosphorus nerve agents by the phosphotriesterase from Pseudomonas diminuta
Arch. Biochem. Biophys.
277
155-159
1990
Brevundimonas diminuta
Efremenko, E.N.; Sergeeva, V.S.
Organophosphate hydrolase - an enzyme catalyzing degradation of phosphorus-containing toxins and pesticides
Russ. Chem. Bull. (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya)
50
1826-1832
2001
Brevundimonas diminuta, Flavobacterium sp., Rattus norvegicus
-
Cho, C.M.H.; Mulchandani, A.; Chen, W.
Bacterial cell surface display of organophosphorus hydrolase for selective screening of improved hydrolysis of organophosphate nerve agents
Appl. Environ. Microbiol.
68
2026-2030
2002
Escherichia coli
Rodrigo, L.; Gil, F.; Hernandez, A.F.; Marina, A.; Vazquez, J.; Pla, A.
Purification and characterization of paraoxon hydrolase from rat liver
Biochem. J.
321
595-601
1997
Rattus norvegicus
Josse, D.; Ebel, C.; Stroebel, D.; Fontaine, A.; Borges, F.; Echalier, A.; Baud, D.; Renault, F.; le Maire, M.; Chabrieres, E.; Masson, P.
Oligomeric states of the detergent-solubilized human serum paraoxonase (PON1)
J. Biol. Chem.
277
33386-33397
2002
Homo sapiens
Rodrigo, L.; Gil, F.; Hernandez, A.F.; Pla, A.
Identification of two rat liver proteins with paraoxonase activity: biochemical evidence for the identity of paraoxonase and arylesterase
Chem. Biol. Interact.
119-120
263-275
1999
Rattus norvegicus
Deakin, S.; Leviev, I.; Gomaraschi, M.; Calabresi, L.; Franceschini, G.; James, R.W.
Enzymatically active paraoxonase-1 is located at the external membrane of producing cells and released by a high affinity, saturable, desorption mechanism
J. Biol. Chem.
277
4301-4308
2002
Homo sapiens
Benning, M.M.; Hong, S.B.; Raushel, F.M.; Holden, H.M.
The binding of substrate analogs to phosphotriesterase
J. Biol. Chem.
275
30556-30560
2000
Brevundimonas diminuta
Ng, C.J.; Wadleigh, D.J.; Gangopadhyay, A.; Hama, S.; Grijalva, V.R.; Navab, M.; Fogelman, A.M.; Reddy, S.T.
Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein
J. Biol. Chem.
276
44444-44449
2001
Homo sapiens
Sorenson, R.C.; Primo-Parmo, S.L.; Kuo, C.L.; Adkins, S.; Lockridge, O.; La Du, B.N.
Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase
Proc. Natl. Acad. Sci. USA
92
7187-7191
1995
Homo sapiens
Costa, L.G.; Li, W.F.; Richter, R.J.; Shih, D.M.; Lusis, A.; Furlong, C.E.
The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism
Chem. Biol. Interact.
119-120
429-438
1999
Homo sapiens
Kuo, C.L.; La Du, B.N.
Comparison of purified human and rabbit serum paraoxonases
Drug Metab. Dispos.
23
935-944
1995
Oryctolagus cuniculus, Homo sapiens
La Du, B.N.; Billecke, S.; Hsu, C.; Haley, R.W.; Broomfield, C.A.
Serum paraoxonase (PON1) isozymes: the quantitative analysis of isozymes affecting individual sensitivity to environmental chemicals
Drug Metab. Dispos.
29
566-569
2001
Homo sapiens (P27169)
Serhatlioglu, S.; Gursu, M.F.; Gulcu, F.; Canatan, H.; Godekmerdan, A.
Levels of paraoxonase and arylesterase activities and malondialdehyde in workers exposed to ionizing radiation
Cell Biochem. Funct.
21
371-375
2003
Homo sapiens
Ahmed, Z.; Babaei, S.; Maguire, G.F.; Draganov, D.; Kuksis, A.; La Du, B.N.; Connelly, P.W.
Paraoxonase-1 reduces monocyte chemotaxis and adhesion to endothelial cells due to oxidation of palmitoyl, linoleoyl glycerophosphorylcholine
Cardiovasc. Res.
57
225-231
2003
Homo sapiens
Ahmed, Z.; Ravandi, A.; Maguire, G.F.; Emili, A.; Draganov, D.; La Du, B.N.; Kuksis, A.; Connelly, P.W.
Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite
Biochem. Biophys. Res. Commun.
290
391-396
2002
Homo sapiens
Leviev, I.; Deakin, S.; James, R.W.
Decreased stability of the M54 isoform of paraoxonase as a contributory factor to variations in human serum paraoxonase concentrations
J. Lipid Res.
42
528-535
2001
Homo sapiens
Banzon, J.A.; Kuo, J.M.; Miles, B.W.; Fischer, D.R.; Stang, P.J.; Raushel, F.M.
Mechanism-based inactivation of phosphotriesterase by reaction of a critical histidine with a ketene intermediate
Biochemistry
34
743-749
1995
Brevundimonas diminuta
Doorn, J.A.; Sorenson, R.C.; Billecke, S.S.; Hsu, C.; La Du, B.N.
Evidence that several conserved histidine residues are required for hydrolytic activity of human paraoxonase/arylesterase
Chem. Biol. Interact.
119-120
235-241
1999
Homo sapiens
Costa, L.G.; Cole, T.B.; Furlong, C.E.
Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates
J. Toxicol. Clin. Toxicol.
41
37-45
2003
Homo sapiens
Devorshak, C.; Roe, R.M.
Purification and characterization of a phosphoric triester hydrolase from the tufted apple bud moth, Platynota idaeusalis (Walker)
J. Biochem. Mol. Toxicol.
15
55-65
2001
Platynota idaeusalis
Li, W.S.; Lum, K.T.; Chen-Goodspeed, M.; Sogorb, M.A.; Raushel, F.M.
Stereoselective detoxification of chiral sarin and soman analogues by phosphotriesterase
Bioorg. Med. Chem.
9
2083-2091
2001
Brevundimonas diminuta
Mulbry, W.
Characterization of a novel organophosphorus hydrolase from Nocardiodes simplex NRRL B-24074
Microbiol. Res.
154
285-288
2000
Pimelobacter simplex
Kuo, C.L.; La Du, B.N.
Calcium binding by human and rabbit serum paraoxonases. Structural stability and enzymic activity
Drug Metab. Dispos.
26
653-660
1998
Oryctolagus cuniculus, Homo sapiens
Rodrigo, L.; Gil, F.; Hernandez, A.F.; Lopez, O.; Pla, A.
Identification of paraoxonase 3 in rat liver microsomes: purification and biochemical properties
Biochem. J.
376
261-268
2003
Rattus norvegicus (Q68FP2)
Billecke, S.; Draganov, D.; Counsell, R.; Stetson, P.; Watson, C.; Hsu, C.; La Du, B.N.
Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters
Drug Metab. Dispos.
28
1335-1342
2000
Homo sapiens (P27169), Homo sapiens
Brushia, R.J.; Forte, T.M.; Oda, M.N.; La Du, B.N.; Bielicki, J.K.
Baculovirus-mediated expression and purification of human serum paraoxonase 1A
J. Lipid Res.
42
951-958
2001
Homo sapiens
Soukharev, S.; Hammond, D.J.
A fluorogenic substrate for detection of organophosphatase activity
Anal. Biochem.
327
140-148
2004
Homo sapiens
Cho, C.M.; Mulchandani, A.; Chen, W.
Altering the substrate specificity of organophosphorus hydrolase for enhanced hydrolysis of chlorpyrifos
Appl. Environ. Microbiol.
70
4681-4685
2004
Escherichia coli K-12 (P37669), Escherichia coli K-12 XL1-Blue (P37669)
Grimsley, J.K.; Calamini, B.; Wild, J.R.; Mesecar, A.D.
Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site
Arch. Biochem. Biophys.
442
169-179
2005
Brevundimonas diminuta (P0A434)
Herkenhoff, S.; Szinicz, L.; Rastogi, V.K.; Cheng, T.C.; DeFrank, J.J.; Worek, F.
Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase
Arch. Toxicol.
78
338-343
2004
Brevundimonas diminuta
Aubert, S.D.; Li, Y.; Raushel, F.M.
Mechanism for the hydrolysis of organophosphates by the bacterial phosphotriesterase
Biochemistry
43
5707-5715
2004
Brevundimonas diminuta (P0A434), Brevundimonas diminuta
Gaidukov, L.; Tawfik, D.S.
High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I
Biochemistry
44
11843-11854
2005
Homo sapiens (P27169)
Khersonsky, O.; Tawfik, D.S.
Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase
Biochemistry
44
6371-6382
2005
Homo sapiens (P27169)
Sinan, S.; Kockar, F.; Gencer, N.; Yildirim, H.; Arslan, O.
Amphenicol and macrolide derived antibiotics inhibit paraoxonase enzyme activity in human serum and human hepatoma cells (HepG2) in vitro
Biochemistry (Moscow)
71
46-50
2006
Homo sapiens
Yeung, D.T.; Josse, D.; Nicholson, J.D.; Khanal, A.; McAndrew, C.W.; Bahnson, B.J.; Lenz, D.E.; Cerasoli, D.M.
Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model
Biochim. Biophys. Acta
1702
67-77
2004
Homo sapiens, Homo sapiens (P27169)
Lei, Y.; Mulchandani, A.; Chen, W.
Improved degradation of organophosphorus nerve agents and p-nitrophenol by Pseudomonas putida JS444 with surface-expressed organophosphorus hydrolase
Biotechnol. Prog.
21
678-681
2005
Pseudomonas putida, Pseudomonas putida JS444
Bergmeier, C.; Siekmeier, R.; Gross, W.
Distribution spectrum of paraoxonase activity in HDL fractions
Clin. Chem.
50
2309-2315
2004
Homo sapiens
Costa, L.G.; Cole, T.B.; Vitalone, A.; Furlong, C.E.
Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity
Clin. Chim. Acta
352
37-47
2005
Homo sapiens
Liu, Y.H.; Liu, Y.; Chen, Z.S.; Lian, J.; Huang, X.; Chung, Y.C.
Purification and characterization of a novel organophosphorus pesticide hydrolase from Penicillium lilacinum BP303
Enzyme Microb. Technol.
34
297-303
2004
Purpureocillium lilacinum, Purpureocillium lilacinum BP303
-
Yeung, D.T.; Lenz, D.E.; Cerasoli, D.M.
Analysis of active-site amino-acid residues of human serum paraoxonase using competitive substrates
FEBS J.
272
2225-2230
2005
Homo sapiens (P27169), Homo sapiens
James, R.W.; Deakin, S.P.
The importance of high-density lipoproteins for paraoxonase-1 secretion, stability, and activity
Free Radic. Biol. Med.
37
1986-1994
2004
Homo sapiens, Mus musculus
Khersonsky, O.; Tawfik, D.S.
The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases
J. Biol. Chem.
281
7649-7656
2006
Homo sapiens (P27169)
Draganov, D.I.; Teiber, J.F.; Speelman, A.; Osawa, Y.; Sunahara, R.; La Du, B.N.
Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities
J. Lipid Res.
46
1239-1247
2005
Homo sapiens (P27169), Homo sapiens (Q15166)
Briseno-Roa, L.; Hill, J.; Notman, S.; Sellers, D.; Smith, A.P.; Timperley, C.M.; Wetherell, J.; Williams, N.H.; Williams, G.R.; Fersht, A.R.; Griffiths, A.D.
Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents
J. Med. Chem.
49
246-255
2006
Brevundimonas diminuta, Homo sapiens
Miyamoto, T.; Takahashi, Y.; Oohashi, T.; Sato, K.; Oikawa, S.
Bovine paraoxonase 1 activities in serum and distribution in lipoproteins
J. Vet. Med. Sci.
67
243-248
2005
Bos taurus
Harel, M.; Aharoni, A.; Gaidukov, L.; Brumshtein, B.; Khersonsky, O.; Meged, R.; Dvir, H.; Ravelli, R.B.G.; McCarthy, A.; Toker, L.; Silman, I.; Sussman, J.L.; Tawfik, D.S.
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes
Nat. Struct. Mol. Biol.
11
412-419
2004
Homo sapiens (P27169)
Jackson, C.J.; Liu, J.W.; Coote, M.L.; Ollis, D.L.
The effects of substrate orientation on the mechanism of a phosphotriesterase
Org. Biomol. Chem.
3
4343-4350
2005
Agrobacterium tumefaciens (Q93LD7)
Aharoni, A.; Gaidukov, L.; Yagur, S.; Toker, L.; Silman, I.; Tawfik, D.S.
Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization
Proc. Natl. Acad. Sci. USA
101
482-487
2004
Homo sapiens (P27169), Homo sapiens (Q15166), Mus musculus (Q62087), Oryctolagus cuniculus (Q9BGN0)
Roodveldt, C.; Tawfik, D.S.
Directed evolution of phosphotriesterase from Pseudomonas diminuta for heterologous expression in Escherichia coli results in stabilization of the metal-free state
Protein Eng. Des. Sel.
18
51-58
2005
Brevundimonas diminuta (P0A434), Brevundimonas diminuta
Cho, C.M.H.; Mulchandani, A.; Chen, W.
Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides
Protein Eng. Des. Sel.
19
99-105
2006
Escherichia coli, Escherichia coli K-12, Escherichia coli K-12 XL1-Blue
Fu, G.; Cui, Z.; Huang, T.; Li, S.
Expression, purification, and characterization of a novel methyl parathion hydrolase
Protein Expr. Purif.
36
170-176
2004
Plesiomonas sp. (Q9ALW1), Plesiomonas sp., Plesiomonas sp. M6 (Q9ALW1)
Kiderlen, D.; Eyer, P.; Worek, F.
Formation and disposition of diethylphosphoryl-obidoxime, a potent anticholinesterase that is hydrolyzed by human paraoxonase (PON1)
Biochem. Pharmacol.
69
1853-1867
2005
Homo sapiens
Costa, L.G.; Vitalone, A.; Cole, T.B.; Furlong, C.E.
Modulation of paraoxonase (PON1) activity
Biochem. Pharmacol.
69
541-550
2005
Homo sapiens
Thomas-Moya, E.; Gianotti, M.; Llado, I.; Proenza, A.M.
Effects of caloric restriction and gender on rat serum paraoxonase 1 activity
J. Nutr. Biochem.
17
197-203
2006
Rattus norvegicus
Pasca, S.P.; Nemes, B.; Vlase, L.; Gagyi, C.E.; Dronca, E.; Miu, A.C.; Dronca, M.
High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism
Life Sci.
78
2244-2248
2006
Homo sapiens
Kilic, S.S.; Aydin, S.; Kilic, N.; Erman, F.; Celik, I.
Serum arylesterase and paraoxonase activity in patients with chronic hepatitis
World J. Gastroenterol.
11
7351-7354
2005
Homo sapiens (P27169), Homo sapiens
Sumegova, K.; Blazicek, P.; Waczulikova, I.; Zitnanova, I.; Durackova, Z.
Activity of paraoxonase 1 (PON1) and its relationship to markers of lipoprotein oxidation in healthy Slovaks
Acta Biochim. Pol.
53
783-787
2006
Homo sapiens (P27169)
Elias, M.; Dupuy, J.; Merone, L.; Lecomte, C.; Rossi, M.; Masson, P.; Manco, G.; Chabriere, E.
Crystallization and preliminary X-ray diffraction analysis of the hyperthermophilic Sulfolobus solfataricus phosphotriesterase
Acta Crystallogr. Sect. F
63
553-555
2007
Saccharolobus solfataricus, Saccharolobus solfataricus MT-4 / DSM 5833
Juretic, D.; Motejlkova, A.; Kunovi?, B.; Reki?, B.; Flegar-Mestri?, Z.; Vuji?, L.; Mesi?, R.; Lukac-Bajalo, J.; Simeon-Rudolf, V.
Paraoxonase/arylesterase in serum of patients with type II diabetes mellitus
Acta Pharm.
56
59-68
2006
Homo sapiens
Walker, J.P.; Kimble, K.W.; Asher, S.A.
Photonic crystal sensor for organophosphate nerve agents utilizing the organophosphorus hydrolase enzyme
Anal. Bioanal. Chem.
389
2115-2124
2007
Homo sapiens
Saruhan, E.; Olgun, A.; Oztuerk, K.; Akman, S.; Erbil, M.K.
Age-related paraoxonase activity changes in Turkish population
Ann. N. Y. Acad. Sci.
1100
218-222
2007
Homo sapiens
Efremenko, E.; Votchitseva, Y.; Plieva, F.; Galaev, I.; Mattiasson, B.
Purification of His6-organophosphate hydrolase using monolithic supermacroporous polyacrylamide cryogels developed for immobilized metal affinity chromatography
Appl. Microbiol. Biotechnol.
70
558-563
2006
Brevundimonas diminuta
Muacevic-Katanec, D.; Bradamante, V.; Poljicanin, T.; Reiner, Z.; Babic, Z.; Simeon-Rudolf, V.; Katanec, D.
Clinical study on the effect of simvastatin on paraoxonase activity
Arzneimittelforschung
57
647-653
2007
Homo sapiens
Santanam, N.; Parthasarathy, S.
Aspirin is a substrate for paraoxonase-like activity: implications in atherosclerosis
Atherosclerosis
191
272-275
2007
Homo sapiens (P27169), Homo sapiens
Aslan, M.; Nazligul, Y.; Horoz, M.; Bolukbas, C.; Bolukbas, F.F.; Gur, M.; Celik, H.; Erel, O.
Serum paraoxonase-1 activity in Helicobacter pylori infected subjects
Atherosclerosis
196
270-274
2008
Homo sapiens
Jackson, C.J.; Carr, P.D.; Kim, H.K.; Liu, J.W.; Herrald, P.; Mitic, N.; Schenk, G.; Smith, C.A.; Ollis, D.L.
Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: the prominent role of iron in the heterobinuclear active site
Biochem. J.
397
501-508
2006
Agrobacterium tumefaciens (Q93LD7), Agrobacterium tumefaciens
Rochu, D.; Chabriere, E.; Renault, F.; Elias, M.; Clery-Barraud, C.; Masson, P.
Stabilization of the active form(s) of human paraoxonase by human phosphate-binding protein
Biochem. Soc. Trans.
35
1616-1620
2007
Homo sapiens
Votchitseva, Y.A.; Efremenko, E.N.; Aliev, T.K.; Varfolomeyev, S.D.
Properties of hexahistidine-tagged organophosphate hydrolase
Biochemistry (Moscow)
71
167-172
2006
Brevundimonas diminuta, Brevundimonas diminuta VKM B-1297
Nguyen, S.D.; Sok, D.E.
Preferable stimulation of PON1 arylesterase activity by phosphatidylcholines with unsaturated acyl chains or oxidized acyl chains at sn-2 position
Biochim. Biophys. Acta
1758
499-508
2006
Homo sapiens (P27169)
Rochu, D.; Renault, F.; Clery-Barraud, C.; Chabriere, E.; Masson, P.
Stability of highly purified human paraoxonase (PON1): Association with human phosphate binding protein (HPBP) is essential for preserving its active conformation(s)
Biochim. Biophys. Acta
1774
874-883
2007
Homo sapiens (P27169)
Sinan, S.; Kockar, F.; Arslan, O.
Novel purification strategy for human PON1 and inhibition of the activity by cephalosporin and aminoglikozide derived antibiotics
Biochimie
88
565-574
2006
Homo sapiens
Walker, A.W.; Keasling, J.D.
Metabolic engineering of Pseudomonas putida for the utilization of parathion as a carbon and energy source.
Biotechnol. Bioeng.
78
715-721
2002
Pseudomonas putida, Pseudomonas putida KT 2442
Forrest, S.R.; Elmore, B.B.; Palmer, J.D.
Activity and lifetime of organophosphorous hydrolase (OPH) immobilized using layer-by-layer nano self-assembly on silicon microchannels
Catal. Today
120
30-34
2006
Homo sapiens
-
Sirivarasai, J.; Kaojarern, S.; Yoovathaworn, K.; Sura, T.
Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects
Chem. Biol. Interact.
168
184-192
2007
Homo sapiens (P27169), Homo sapiens
Can Demirdoegen, B.; Tuerkanoglu, A.; Bek, S.; Sanisoglu, Y.; Demirkaya, S.; Vural, O.; Arinc, E.; Adali, O.
Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischemic stroke
Clin. Biochem.
41
1-9
2008
Homo sapiens (P27169)
Schulpis, K.H.; Karikas, G.A.; Bartzeliotou, A.; Papakonstantinou, E.D.; Kalogerakou, M.; Tsakiris, S.
The effect of diet on paraoxonase 1/arylesterase activities in patients with disorders of galactose metabolism
Clin. Endocrinol. (Oxf.)
67
687-692
2007
Homo sapiens (P27169)
Isik, A.; Koca, S.S.; Ustundag, B.; Celik, H.; Yildirim, A.
Paraoxonase and arylesterase levels in rheumatoid arthritis
Clin. Rheumatol.
26
342-348
2007
Homo sapiens (P27169)
Catano, H.C.; Cueva, J.L.; Cardenas, A.M.; Izaguirre, V.; Zavaleta, A.I.; Carranza, E.; Hernandez, A.F.
Distribution of paraoxonase-1 gene polymorphisms and enzyme activity in a Peruvian population
Environ. Mol. Mutagen.
47
699-706
2006
Homo sapiens (P27169)
Schulpis, K.H.; Bartzeliotou, A.; Tsakiris, S.; Gounaris, A.; Papassotiriou, I.
Serum paraoxonase/arylesterase activities in phenylketonuric patients on diet
Eur. J. Clin. Nutr.
61
803-808
2007
Homo sapiens (P27169), Homo sapiens
Merone, L.; Mandrich, L.; Rossi, M.; Manco, G.
A thermostable phosphotriesterase from the archaeon Sulfolobus solfataricus: cloning, overexpression and properties
Extremophiles
9
297-305
2005
Saccharolobus solfataricus, Saccharolobus solfataricus MT-4 / DSM 5833
Yeung, D.T.; Smith, J.R.; Sweeney, R.E.; Lenz, D.E.; Cerasoli, D.M.
Direct detection of stereospecific soman hydrolysis by wild-type human serum paraoxonase
FEBS J.
274
1183-1191
2007
Homo sapiens
Blum, M.M.; Loehr, F.; Richardt, A.; Rueterjans, H.; Chen, J.C.
Binding of a designed substrate analogue to diisopropyl fluorophosphatase: implications for the phosphotriesterase mechanism
J. Am. Chem. Soc.
128
12750-12757
2006
Loligo vulgaris
Renault, F.; Chabriere, E.; Andrieu, J.; Dublet, B.; Masson, P.; Rochu, D.
Tandem purification of two HDL-associated partner proteins in human plasma, paraoxonase (PON1) and phosphate binding protein (HPBP) using hydroxyapatite chromatography
J. Chromatogr. B
836
15-21
2006
Homo sapiens (P27169)
Gaidukov, L.; Tawfik, D.S.
The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity
J. Lipid Res.
48
1637-1646
2007
Homo sapiens (P27169), Homo sapiens
Jackson, C.J.; Foo, J.L.; Kim, H.K.; Carr, P.D.; Liu, J.W.; Salem, G.; Ollis, D.L.
In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
J. Mol. Biol.
375
1189-1196
2008
Agrobacterium tumefaciens (Q93LD7), Agrobacterium tumefaciens
Park, C.H.; Nguyen, S.D.; Kim, M.R.; Jeong, T.S.; Sok, D.E.
Differential effect of lysophospholipids on activities of human plasma paraoxonase1, either soluble or lipid-bound
Lipids
41
371-380
2006
Homo sapiens (P27169)
Chu, X.Y.; Wu, N.F.; Deng, M.J.; Tian, J.; Yao, B.; Fan, Y.L.
Expression of organophosphorus hydrolase OPHC2 in Pichia pastoris: purification and characterization
Protein Expr. Purif.
49
9-14
2006
Pseudomonas oleovorans (Q5W503), Pseudomonas oleovorans C2-1 (Q5W503)
Votchitseva, Y.A.; Efremenko, E.N.; Varfolomeyev, S.D.
Insertion of an unnatural amino acid into the protein structure: preparation and properties of 3-fluorotyrosine-containing organophosphate hydrolase
Russ. Chem. Bull.
55
369-374
2006
Brevundimonas diminuta
-
Huang, L.F.; Su, B.; Jao, S.C.; Liu, K.T.; Li, W.S.
Aminopeptidase P mediated detoxification of organophosphonate analogues of sarin: mechanistic and stereochemical study at the phosphorus atom of the substrate
Chembiochem
7
506-514
2006
Escherichia coli
Farid, A.S.; Nakahara, K.; Murakami, N.; Hayashi, T.; Horii, Y.
Decreased serum paraoxonase-1 activity during intestinal nematode (Nippostrongylus brasiliensis) infection in rats
Am. J. Trop. Med. Hyg.
78
770-776
2008
Rattus norvegicus (P55159), Rattus norvegicus
Kanamori-Kataoka, M.; Seto, Y.
Paraoxonase activity against nerve gases measured by capillary electrophoresis and characterization of human serum paraoxonase (PON1) polymorphism in the coding region (Q192R)
Anal. Biochem.
385
94-100
2009
Homo sapiens (P27169), Homo sapiens
Abd-Allah, G.M.; Mariee, A.D.
Nitrite-mediated inactivation of human plasma paraoxonase-1: possible beneficial effect of aromatic amino acids
Appl. Biochem. Biotechnol.
150
281-288
2008
Homo sapiens (P27169), Homo sapiens
Efrat, M.; Rosenblat, M.; Mahmood, S.; Vaya, J.; Aviram, M.
Di-oleoyl phosphatidylcholine (PC-18:1) stimulates paraoxonase 1 (PON1) enzymatic and biological activities: in vitro and in vivo studies
Atherosclerosis
202
461-469
2009
Mus musculus (P52430)
Blum, M.M.; Timperley, C.M.; Williams, G.R.; Thiermann, H.; Worek, F.
Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase
Biochemistry
47
5216-5224
2008
Homo sapiens (P27169), Homo sapiens
Kotur-Stevuljevic, J.; Spasic, S.; Jelic-Ivanovic, Z.; Spasojevic-Kalimanovska, V.; Stefanovic, A.; Vujovic, A.; Memon, L.; Kalimanovska-Ostric, D.
PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients
Clin. Biochem.
41
1067-1073
2008
Homo sapiens (P27169)
Alici, H.A.; Ekinci, D.; Beydemir, S.
Intravenous anesthetics inhibit human paraoxonase-1 (PON1) activity in vitro and in vivo
Clin. Biochem.
41
1384-1390
2008
Homo sapiens (P27169), Homo sapiens
Schulpis, K.H.; Barzeliotou, A.; Papadakis, M.; Rodolakis, A.; Antsaklis, A.; Papassotiriou, I.; Vlachos, G.D.
Maternal chronic hepatitis B virus is implicated with low neonatal paraoxonase/arylesterase activities
Clin. Biochem.
41
282-287
2008
Homo sapiens (P27169), Homo sapiens
Yildiz, A.; Gur, M.; Demirbag, R.; Yilmaz, R.; Akyol, S.; Aslan, M.; Erel, O.
Paraoxonase and arylesterase activities in untreated dipper and non-dipper hypertensive patients
Clin. Biochem.
41
779-784
2008
Homo sapiens (P27169), Homo sapiens
Barim, A.O.; Aydin, S.; Colak, R.; Dag, E.; Deniz, O.; Sahin, I.
Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment
Clin. Biochem.
42
1076-1081
2009
Homo sapiens (P27169)
Kasprzak, M.; Iskra, M.; Majewski, W.; Wielkoszynski, T.
Arylesterase and paraoxonase activity of paraoxonase (PON1) affected by ischemia in the plasma of patients with arterial occlusion of the lower limbs
Clin. Biochem.
42
50-56
2009
Homo sapiens (P27169)
Garces, C.; Lopez-Simon, L.; Rubio, R.; Benavente, M.; Cano, B.; Ortega, H.; de Oya, M.
High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain
Clin. Chem. Lab. Med.
46
809-813
2008
Homo sapiens (P27169)
Kotani, K.; Kimura, S.; Tsuzaki, K.; Sakane, N.; Komada, I.; Schulze, J.; Gugliucci, A.
Reduced paraoxonase 1/arylesterase activity and its post-therapeutic increase in obstructive sleep apnea syndrome: A preliminary study
Clin. Chim. Acta
395
184-185
2008
Homo sapiens (P27169)
van den Berg, S.W.; Jansen, E.H.; Kruijshoop, M.; Beekhof, P.K.; Blaak, E.; van der Kallen, C.J.; van Greevenbroek, M.M.; Feskens, E.J.
Paraoxonase 1 phenotype distribution and activity differs in subjects with newly diagnosed Type 2 diabetes (the CODAM Study)
Diabet. Med.
25
186-193
2008
Homo sapiens (P27169)
Marsillach, J.; Mackness, B.; Mackness, M.; Riu, F.; Beltran, R.; Joven, J.; Camps, J.
Immunohistochemical analysis of paraoxonases-1, 2, and 3 expression in normal mouse tissues
Free Radic. Biol. Med.
45
146-157
2008
Mus musculus (P52430), Mus musculus (Q62086)
Liu, Y.; Mackness, B.; Mackness, M.
Comparison of the ability of paraoxonases 1 and 3 to attenuate the in vitro oxidation of low-density lipoprotein and reduce macrophage oxidative stress
Free Radic. Biol. Med.
45
743-748
2008
Homo sapiens (P27169)
Camuzcuoglu, H.; Arioz, D.T.; Toy, H.; Kurt, S.; Celik, H.; Erel, O.
Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer
Gynecol. Oncol.
112
481-485
2009
Homo sapiens (P27169), Homo sapiens
Parker-Katiraee, L.; Bousiaki, E.; Monk, D.; Moore, G.E.; Nakabayashi, K.; Scherer, S.W.
Dynamic variation in allele-specific gene expression of Paraoxonase-1 in murine and human tissues
Hum. Mol. Genet.
17
3263-3270
2008
Mus musculus (P52430)
Rock, W.; Rosenblat, M.; Miller-Lotan, R.; Levy, A.P.; Elias, M.; Aviram, M.
Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities
J. Agric. Food Chem.
56
8704-8713
2008
Homo sapiens (P27169)
Park, Y.J.; Yoon, S.J.; Lee, H.B.
A novel thermostable arylesterase from the archaeon Sulfolobus solfataricus P1: purification, characterization, and expression
J. Bacteriol.
190
8086-8095
2008
Saccharolobus solfataricus (B5BLW5), Saccharolobus solfataricus P1 (B5BLW5)
Pasca, S.P.; Dronca, E.; Nemes, B.; Kaucsar, T.; Endreffy, E.; Iftene, F.; Benga, I.; Cornean, R.; Dronca, M.
Paraoxonase 1 activities and polymorphisms in autism spectrum disorders
J. Cell. Mol. Med.
14
600-607
2010
Homo sapiens
Stoltz, D.A.; Ozer, E.A.; Taft, P.J.; Barry, M.; Liu, L.; Kiss, P.J.; Moninger, T.O.; Parsek, M.R.; Zabner, J.
Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1
J. Clin. Invest.
118
3123-3131
2008
Homo sapiens (P27169)
Aksoy, H.; Aksoy, A.N.; Ozkan, A.; Polat, H.
Serum lipid profile, oxidative status, and paraoxonase 1 activity in hyperemesis gravidarum
J. Clin. Lab. Anal.
23
105-109
2009
Homo sapiens (P27169)
Jaichander, P.; Selvarajan, K.; Garelnabi, M.; Parthasarathy, S.
Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin
J. Lipid Res.
49
2142-2148
2008
Homo sapiens (P27169), Mus musculus (P52430)
Chungjatupornchai, W.; Fa-Aroonsawat, S.
Biodegradation of organophosphate pesticide using recombinant Cyanobacteria with surface- and intracellular-expressed organophosphorus hydrolase
J. Microbiol. Biotechnol.
18
946-951
2008
Flavobacterium sp. (P0A433), Flavobacterium sp.
Elias, M.; Dupuy, J.; Merone, L.; Mandrich, L.; Porzio, E.; Moniot, S.; Rochu, D.; Lecomte, C.; Rossi, M.; Masson, P.; Manco, G.; Chabriere, E.
Structural basis for natural lactonase and promiscuous phosphotriesterase activities
J. Mol. Biol.
379
1017-1028
2008
Saccharolobus solfataricus (Q97VT7), Saccharolobus solfataricus
Wills, A.M.; Landers, J.E.; Zhang, H.; Richter, R.J.; Caraganis, A.J.; Cudkowicz, M.E.; Furlong, C.E.; Brown, R.H.
Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS
Neurology
70
929-934
2008
Homo sapiens (P27169)
Stevens, R.C.; Suzuki, S.M.; Cole, T.B.; Park, S.S.; Richter, R.J.; Furlong, C.E.
Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning
Proc. Natl. Acad. Sci. USA
105
12780-12784
2008
Homo sapiens (P27169)
Reeves, T.E.; Wales, M.E.; Grimsley, J.K.; Li, P.; Cerasoli, D.M.; Wild, J.R.
Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities
Protein Eng. Des. Sel.
21
405-412
2008
Brevundimonas diminuta (P0A434)
Hu, X.; Jiang, X.; Lenz, D.E.; Cerasoli, D.M.; Wallqvist, A.
In silico analyses of substrate interactions with human serum paraoxonase 1
Proteins
75
486-498
2009
Homo sapiens (P27169), Homo sapiens
Richter, R.J.; Jarvik, G.P.; Furlong, C.E.
Paraoxonase 1 (PON1) status and substrate hydrolysis
Toxicol. Appl. Pharmacol.
235
1-9
2009
Homo sapiens (P27169)
Hsu, Y.T.; Su, C.Y.; Du, H.C.; Jao, S.C.; Li, W.S.
Evaluation of organophosphorus chemicals-degrading enzymes: a comparison of Escherichia coli and human cytosolic aminopeptidase P
Chem. Biodivers.
5
1401-1411
2008
Escherichia coli (P15034), Homo sapiens (Q9NQW7)
Nguyen, S.D.; Hung, N.D.; Cheon-Ho, P.; Ree, K.M.; Dai-Eun, S.
Oxidative inactivation of lactonase activity of purified human paraoxonase 1 (PON1)
Biochim. Biophys. Acta
1790
155-160
2009
Homo sapiens
Popa, C.; van Tits, L.J.; Barrera, P.; Lemmers, H.L.; van den Hoogen, F.H.; van Riel, P.L.; Radstake, T.R.; Netea, M.G.; Roest, M.; Stalenhoef, A.F.
Anti-inflammatory therapy with tumour necrosis factor alpha inhibitors improves high-density lipoprotein cholesterol antioxidative capacity in rheumatoid arthritis patients
Ann. Rheum. Dis.
68
868-872
2009
Homo sapiens
Samra, Z.Q.; Shabir, S.; Rehmat, Z.; Zaman, M.; Nazir, A.; Dar, N.; Athar, M.A.
Synthesis of cholesterol-conjugated magnetic nanoparticles for purification of human paraoxonase 1
Appl. Biochem. Biotechnol.
162
671-686
2010
Homo sapiens
Hawwa, R.; Aikens, J.; Turner, R.J.; Santarsiero, B.D.; Mesecar, A.D.
Structural basis for thermostability revealed through the identification and characterization of a highly thermostable phosphotriesterase-like lactonase from Geobacillus stearothermophilus
Arch. Biochem. Biophys.
488
109-120
2009
Geobacillus stearothermophilus, Geobacillus stearothermophilus 10
Ashani, Y.; Gupta, R.D.; Goldsmith, M.; Silman, I.; Sussman, J.L.; Tawfik, D.S.; Leader, H.
Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers
Chem. Biol. Interact.
187
362-369
2010
synthetic construct
Otto, T.C.; Kasten, S.A.; Kovaleva, E.; Liu, Z.; Buchman, G.; Tolosa, M.; Davis, D.; Smith, J.R.; Balcerzak, R.; Lenz, D.E.; Cerasoli, D.M.
Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae
Chem. Biol. Interact.
187
388-392
2010
Homo sapiens
Gencer, N.; Arslan, O.
Purification human PON1Q192 and PON1R192 isoenzymes by hydrophobic interaction chromatography and investigation of the inhibition by metals
J. Chromatogr. B
877
134-140
2009
Homo sapiens
Renault, F.; Carus, T.; Clery-Barraud, C.; Elias, M.; Chabriere, E.; Masson, P.; Rochu, D.
Integrative analytical approach by capillary electrophoresis and kinetics under high pressure optimized for deciphering intrinsic and extrinsic cofactors that modulate activity and stability of human paraoxonase (PON1)
J. Chromatogr. B
878
1346-1355
2010
Homo sapiens, synthetic construct
Ekinci, D.; Beydemir, S.
Effect of some analgesics on paraoxonase-1 purified from human serum
J. Enzyme Inhib. Med. Chem.
24
1034-1039
2009
Homo sapiens
Carletti, E.; Jacquamet, L.; Loiodice, M.; Rochu, D.; Masson, P.; Nachon, F.
Update on biochemical properties of recombinant Pseudomonas diminuta phosphotriesterase
J. Enzyme Inhib. Med. Chem.
24
1045-1055
2009
Brevundimonas diminuta (P0A434), Brevundimonas diminuta
Fairchild, S.Z.; Peterson, M.W.; Hamza, A.; Zhan, C.G.; Cerasoli, D.M.; Chang, W.E.
Computational characterization of how the VX nerve agent binds human serum paraoxonase 1
J. Mol. Model.
17
97-109
2011
Homo sapiens
Camuzcuoglu, H.; Toy, H.; Cakir, H.; Celik, H.; Erel, O.
Decreased paraoxonase and arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus
J. Womens Health (Larchmt)
18
1435-1439
2009
Homo sapiens
Cole, T.B.; Jansen, K.; Park, S.; Li, W.F.; Furlong, C.E.; Costa, L.G.
The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status
Adv. Exp. Med. Biol.
660
47-60
2010
Mus musculus
Harisa, G.
L-arginine ameliorates arylesterase/paraoxonase activity of paraoxonase-1 in hypercholesterolemic rats
Asian J. Biochem.
6
263-272
2011
Rattus norvegicus
-
Valiyaveettil, M.; Alamneh, Y.; Biggemann, L.; Soojhawon, I.; Doctor, B.P.; Nambiar, M.P.
Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1
Biochem. Biophys. Res. Commun.
403
97-102
2010
Oryctolagus cuniculus, Homo sapiens
Valiyaveettil, M.; Alamneh, Y.; Rezk, P.; Biggemann, L.; Perkins, M.W.; Sciuto, A.M.; Doctor, B.P.; Nambiar, M.P.
Protective efficacy of catalytic bioscavenger, paraoxonase 1 against sarin and soman exposure in guinea pigs
Biochem. Pharmacol.
81
800-809
2011
Oryctolagus cuniculus, Homo sapiens
Tsai, P.C.; Bigley, A.; Li, Y.; Ghanem, E.; Cadieux, C.L.; Kasten, S.A.; Reeves, T.E.; Cerasoli, D.M.; Raushel, F.M.
Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase
Biochemistry
49
7978-7987
2010
Homo sapiens
Moghtaderi, A.; Hashemi, M.; Dabiri, S.; Moazeni-Roodi, A.; Hosseini, M.
Serum paraoxonase and arylesterase activities in patients with lacunar infarction: a case control study
Clin. Biochem.
44
288-292
2011
Homo sapiens
Hashemi, M.; Kordi-Tamandani, D.M.; Sharifi, N.; Moazeni-Roodi, A.; Kaykhaei, M.A.; Narouie, B.; Torkmanzehi, A.
Serum paraoxonase and arylesterase activities in metabolic syndrome in Zahedan, southeast Iran
Eur. J. Endocrinol.
164
219-222
2011
Homo sapiens
Cayir, K.; Bilici, M.; Tekin, S.; Kara, F.; Turkyilmaz, A.; Yildirim, A.
Serum paraoxonase and arylesterase activities in esophageal cancer: A controlled study
Eur. J. Gen. Med.
7
398-403
2010
Homo sapiens
-
Schofield, D.A.; Dinovo, A.A.
Generation of a mutagenized organophosphorus hydrolase for the biodegradation of the organophosphate pesticides malathion and demeton-S
J. Appl. Microbiol.
109
548-557
2010
Flavobacterium sp., Flavobacterium sp. ATCC 27551
Bayrak, A.; Bayrak, T.; Demirpence, E.; Kilinc, K.
Differential hydrolysis of homocysteine thiolactone by purified human serum (192)Q and (192)R PON1 isoenzymes
J. Chromatogr. B
879
49-55
2011
Homo sapiens
Duygu, F.; Tekin Koruk, S.; Aksoy, N.
Serum paraoxonase and arylesterase activities in various forms of hepatitis B virus infection
J. Clin. Lab. Anal.
25
311-316
2011
Homo sapiens
Kockar, F.; Sinan, S.; Yildirim, H.; Arslan, O.
Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (HepG2) in vitro
J. Enzyme Inhib. Med. Chem.
25
715-719
2010
Homo sapiens
Sayin, D.; Cakir, D.T.; Gencer, N.; Arslan, O.
Effects of some metals on paraoxonase activity from shark Scyliorhinus canicula
J. Enzyme Inhib. Med. Chem.
27
595-598
2012
Scyliorhinus canicula
Arslan, M.; Gencer, N.; Arslan, O.; Guler, O.O.
In vitro efficacy of some cattle drugs on bovine serum paraoxonase 1 (PON1) activity
J. Enzyme Inhib. Med. Chem.
27
72272-9
2012
Bos taurus
Lu, H.; Wheeldon, I.; Banta, S.
Catalytic biomaterials: Engineering organophosphate hydrolase to form self-assembling enzymatic hydrogels
Protein Eng. Des. Sel.
23
559-566
2010
Flavobacterium sp., Flavobacterium sp. ATCC 27 551
Valiyaveettil, M.; Alamneh, Y.; Biggemann, L.; Soojhawon, I.; Farag, H.A.; Agrawal, P.; Doctor, B.P.; Nambiar, M.P.
In vitro efficacy of paraoxonase 1 from multiple sources against various organophosphates
Toxicol. In Vitro
25
905-913
2011
Oryctolagus cuniculus, Homo sapiens
Trovaslet-Leroy, M.; Musilova, L.; Renault, F.; Brazzolotto, X.; Misik, J.; Novotny, L.; Froment, M.T.; Gillon, E.; Loiodice, M.; Verdier, L.; Masson, P.; Rochu, D.; Jun, D.; Nachon, F.
Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents
Toxicol. Lett.
206
14-23
2011
Brevundimonas diminuta, Homo sapiens
Del Vecchio, P.; Elias, M.; Merone, L.; Graziano, G.; Dupuy, J.; Mandrich, L.; Carullo, P.; Fournier, B.; Rochu, D.; Rossi, M.; Masson, P.; Chabriere, E.; Manco, G.
Structural determinants of the high thermal stability of SsoPox from the hyperthermophilic archaeon Sulfolobus solfataricus
Extremophiles
13
461-470
2009
Saccharolobus solfataricus (Q97VT7), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97VT7)
Gotthard, G.; Hiblot, J.; Elias, M.; Chabriere, E.
Crystallization and preliminary X-ray diffraction analysis of the hyperthermophilic Sulfolobus islandicus lactonase
Acta Crystallogr. Sect. F
67
354-357
2011
Sulfolobus islandicus (C4KKZ9), Sulfolobus islandicus, Sulfolobus islandicus M.16.4 (C4KKZ9)
Ng, F.S.; Wright, D.M.; Seah, S.Y.
Characterization of a phosphotriesterase-like lactonase from Sulfolobus solfataricus and its immobilization for disruption of quorum sensing
Appl. Environ. Microbiol.
77
1181-1186
2010
Saccharolobus solfataricus (Q97VT7), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97VT7)
Porzio, E.; Merone, L.; Mandrich, L.; Rossi, M.; Manco, G.
A new phosphotriesterase from Sulfolobus acidocaldarius and its comparison with the homologue from Sulfolobus solfataricus
Biochimie
89
625-636
2007
Sulfolobus acidocaldarius (Q4J6Z8), Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DSM 639 (Q4J6Z8)
Merone, L.; Mandrich, L.; Porzio, E.; Rossi, M.; Mller, S.; Reiter, G.; Worek, F.; Manco, G.
Improving the promiscuous nerve agent hydrolase activity of a thermostable archaeal lactonase
Bioresour. Technol.
101
9204-9212
2010
Saccharolobus solfataricus (Q97VT7), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97VT7)
Porzio, E.; Di, Gennaro, S.; Palma, A.; Manco, G.
Mn2+ modulates the kinetic properties of an archaeal member of the PLL family
Chem. Biol. Interact.
203
251-256
2013
Sulfolobus acidocaldarius
Mandrich, L.; Merone, L.; Manco, G.
Hyperthermophilic phosphotriesterases/lactonases for the environment and human health
Environ. Technol.
31
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2010
Saccharolobus solfataricus, Sulfolobus acidocaldarius
Hiblot, J.; Gotthard, G.; Chabriere, E.; Elias, M.
Structural and enzymatic characterization of the lactonase SisLac from Sulfolobus islandicus
PLoS One
7
e47028
2012
Sulfolobus islandicus (C4KKZ9), Sulfolobus islandicus, Sulfolobus islandicus M.16.4 (C4KKZ9)
Hiblot, J.; Gotthard, G.; Chabriere, E.; Elias, M.
Characterisation of the organophosphate hydrolase catalytic activity of SsoPox
Sci. Rep.
2
779
2012
Saccharolobus solfataricus (Q97VT7), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97VT7)
Gotthard, G.; Hiblot, J.; Gonzalez, D.; Chabriere, E.; Elias, M.
Crystallization and preliminary X-ray diffraction analysis of the organophosphorus hydrolase OPHC2 from Pseudomonas pseudoalcaligenes
Acta Crystallogr. Sect. F
69
73-76
2013
Pseudomonas oleovorans (Q5W503), Pseudomonas oleovorans
Erzengin, M.; Basaran, I.; Cakir, U.; Aybey, A.; Sinan, S.
In vitro inhibition effect of some dihydroxy coumarin compounds on purified human serum paraoxonase 1 (PON1)
Appl. Biochem. Biotechnol.
168
1540-1548
2012
Homo sapiens
Erzengin, M.; Demir, D.; Arslan, M.; Sinan, S.
Purification and characterization of paraoxonase 1 (PON1) from Swiss Black, Holstein, and Montofon bovines
Appl. Biochem. Biotechnol.
173
1597-1606
2014
Bos taurus
Sirotkina, M.; Efremenko, E.N.
Rhodococcus lactonase with organophosphate hydrolase (OPH) activity and His6-tagged OPH with lactonase activity: evolutionary proximity of the enzymes and new possibilities in their application
Appl. Microbiol. Biotechnol.
98
2647-2656
2014
Rhodococcus ruber, Rhodococcus erythropolis, Rhodococcus ruber AC-1513D, Rhodococcus erythropolis AC-1514D
Jeong, Y.S.; Choi, J.M.; Kyeong, H.H.; Choi, J.Y.; Kim, E.J.; Kim, H.S.
Rational design of organophosphorus hydrolase with high catalytic efficiency for detoxifying a V-type nerve agent
Biochem. Biophys. Res. Commun.
449
263-267
2014
Flavobacterium sp.
Bajaj, P.; Aggarwal, G.; Tripathy, R.K.; Pande, A.H.
Interplay between amino acid residues at positions 192 and 115 in modulating hydrolytic activities of human paraoxonase 1
Biochimie
105
202-210
2014
Homo sapiens (P27169), Homo sapiens
Dedeoglu, N.; Arslan, M.; Erzengin, M.
Purification of Holstein bull semen paraoxonase 1 (PON1) by hydrophobic interaction chromatography and investigation of its inhibition kinetics by heavy metals
Biol. Trace Elem. Res.
158
29-35
2014
Bos taurus
Bzdrenga, J.; Hiblot, J.; Gotthard, G.; Champion, C.; Elias, M.; Chabriere, E.
SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase
BMC Res. Notes
7
333
2014
Sulfolobus acidocaldarius (Q4J6Z8), Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DSM 639 (Q4J6Z8)
Kartkaya, K.; Oglakci, A.; sentuerk, H.; Bayramoglu, G.; Canbek, M.; Kanbak, G.
Investigation of the possible protective role of gallic acid on paraoxanase and arylesterase activities in livers of rats with acute alcohol intoxication
Cell Biochem. Funct.
31
208-213
2013
Rattus norvegicus
Kim, M.; Gkikas, M.; Huang, A.; Kang, J.W.; Suthiwangcharoen, N.; Nagarajan, R.; Olsen, B.D.
Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer
Chem. Commun. (Camb. )
50
5345-5348
2014
Brevundimonas diminuta
Kallnik, V.; Bunescu, A.; Sayer, C.; Brsen, C.; Wohlgemuth, R.; Littlechild, J.; Siebers, B.
Characterization of a phosphotriesterase-like lactonase from the hyperthermoacidophilic crenarchaeon Vulcanisaeta moutnovskia
J. Biotechnol.
190
11-17
2014
Vulcanisaeta moutnovskia (F0QXN6), Vulcanisaeta moutnovskia
Kirbas, A.; Kirbas, S.; Anlar, O.; Efe, H.; Yilmaz, A.
Serum paraoxonase and arylesterase activity and oxidative status in patients with multiple sclerosis
J. Clin. Neurosci.
20
1106-1109
2013
Homo sapiens
Kirbas, A.; Kirbas, S.; Cure, M.C.; Tufekci, A.
Paraoxonase and arylesterase activity and total oxidative/anti-oxidative status in patients with idiopathic Parkinson's disease
J. Clin. Neurosci.
21
451-455
2014
Homo sapiens
Kati, C.; Karadas, S.; Aslan, M.; Gonullu, H.; Duran, L.; Demir, H.
Serum paraoxonase and arylesterase activities and oxidative stress levels in patients with SSRI intoxication
J. Membr. Biol.
247
17-21
2014
Homo sapiens
Ben-David, M.; Elias, M.; Filippi, J.J.; Dunach, E.; Silman, I.; Sussman, J.L.; Tawfik, D.S.
Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1
J. Mol. Biol.
418
181-196
2012
synthetic construct
Muthukrishnan, S.; Shete, V.S.; Sanan, T.T.; Vyas, S.; Oottikkal, S.; Porter, L.M.; Magliery, T.J.; Hadad, C.M.
Mechanistic insights into the hydrolysis of organophosphorus compounds by paraoxonase-1: exploring the limits of substrate tolerance in a promiscuous enzyme
J. Phys. Org. Chem.
25
1247-1260
2012
synthetic construct
Bajaj, P.; Tripathy, R.K.; Aggarwal, G.; Pande, A.H.
Characterization of human paraoxonase 1 variants suggest that His residues at 115 and 134 positions are not always needed for the lactonase/arylesterase activities of the enzyme
Protein Sci.
22
1799-1807
2013
Homo sapiens (P27169), Homo sapiens
Olama, S.M.; Elarman, M.M.
Evaluation of paraoxonase and arylesterase activities in Egyptian patients with ankylosing spondylitis
Rheumatol. Int.
33
1487-1494
2013
Homo sapiens
Tekin Koruk, S.; Aksoy, N.; Hamidanoglu, M.; Karsen, H.; Unlu, S.; Bilinc, H.
The activity of paraoxonase and arylesterase in patients with osteomyelitis
Scand. J. Clin. Lab. Invest.
72
513-517
2012
Homo sapiens
Hiblot, J.; Bzdrenga, J.; Champion, C.; Chabriere, E.; Elias, M.
Crystal structure of VmoLac, a tentative quorum quenching lactonase from the extremophilic crenarchaeon Vulcanisaeta moutnovskia
Sci. Rep.
5
8372
2015
Vulcanisaeta moutnovskia (F0QXN6), Vulcanisaeta moutnovskia, Vulcanisaeta moutnovskia 768-28 (F0QXN6)
Chambers, J.E.; Chambers, H.W.; Meek, E.C.; Funck, K.E.; Bhavaraju, M.H.; Gwaltney, S.R.; Pringle, R.B.
Novel nucleophiles enhance the human serum paraoxonase 1 (PON1)-mediated detoxication of organophosphates
Toxicol. Sci.
143
46-53
2015
Homo sapiens
Jackson, C.J.; Carville, A.; Ward, J.; Mansfield, K.; Ollis, D.L.; Khurana, T.; Bird, S.B.
Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning
Toxicology
317
1-5
2014
Agrobacterium tumefaciens (Q93LD7), Agrobacterium tumefaciens
Restaino, O.F.; Borzacchiello, M.G.; Scognamiglio, I.; Porzio, E.; Manco, G., Fedele, L., Donatiello, C., De Rosa, M.; Schiraldi, C.
Boosted large-scale production and purification of a thermostable archaeal phosphotriesterase-like lactonase for organophosphate decontamination
J. Ind. Microbiol. Biotechnol.
44
363-375
2017
Saccharolobus solfataricus (Q97VT7), Saccharolobus solfataricus, Saccharolobus solfataricus DSM 1617 (Q97VT7)
Abulimite, Z.; Mu, X.; Xiao, S.; Liu, M.; Li, Q.; Chen, G.
New chemiluminescent substrates of paraoxonase 1 with improved specificity synthesis and properties
Appl. Biochem. Biotechnol.
176
301-316
2015
Homo sapiens (P27169)
Tripathy, R.K.; Aggarwal, G.; Bajaj, P.; Kathuria, D.; Bharatam, P.V.; Pande, A.H.
Towards understanding the catalytic mechanism of human paraoxonase 1 experimental and in silico mutagenesis studies
Appl. Biochem. Biotechnol.
182
1642-1662
2017
Homo sapiens, Homo sapiens (P27169)
Haque, M.; Hong, S.; Hwang, C.; Kim, S.; Cho, K.
Cloning of an organophosphorus hydrolase (opdD) gene of Lactobacillus sakei WCP904 isolated from chlorpyrifos-impregnated kimchi and hydrolysis activities of its gene product for organophosphorus pesticides
Appl. Biol. Chem.
61
643-651
2018
Latilactobacillus sakei, Latilactobacillus sakei WCP904
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Lyagin, I.V.; Andrianova, M.S.; Efremenko, E.N.
Extensive hydrolysis of phosphonates as unexpected behaviour of the known His6-organophosphorus hydrolase
Appl. Microbiol. Biotechnol.
100
5829-5838
2016
Homo sapiens (P27169)
Goldsmith, M.; Eckstein, S.; Ashani, Y.; Greisen, P.; Leader, H.; Sussman, J.L.; Aggarwal, N.; Ovchinnikov, S.; Tawfik, D.S.; Baker, D.; Thiermann, H.; Worek, F.
Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro
Arch. Toxicol.
90
2711-2724
2016
Brevundimonas diminuta (P0A434), Brevundimonas diminuta
Zhang, L.; Wang, H.; Liu, X.; Zhou, W.; Rao, Z.
The crystal structure of the phosphotriesterase from M. tuberculosis, another member of phosphotriesterase-like lactonase family
Biochem. Biophys. Res. Commun.
510
224-229
2019
Mycobacterium tuberculosis (P9WHN9), Mycobacterium tuberculosis H37Rv (P9WHN9), Mycobacterium tuberculosis ATCC 25618 (P9WHN9)
Kul, A.; Uzkeser, H.; Ozturk, N.
Paraoxonase and arylesterase levels in Behcets disease and their relations with the disease activity
Biochem. Genet.
55
335-344
2017
Homo sapiens
Bigley, A.N.; Mabanglo, M.F.; Harvey, S.P.; Raushel, F.M.
Variants of phosphotriesterase for the enhanced detoxification of the chemical warfare agent VR
Biochemistry
54
5502-5512
2015
Brevundimonas diminuta (P0A434)
Mabbitt, P.D.; Correy, G.J.; Meirelles, T.; Fraser, N.J.; Coote, M.L.; Jackson, C.J.
Conformational disorganization within the active site of a recently evolved organophosphate hydrolase limits its catalytic efficiency
Biochemistry
55
1408-1417
2016
Lucilia cuprina
Bigley, A.N.; Narindoshvili, T.; Xiang, D.F.; Raushel, F.M.
Multiple reaction products from the hydrolysis of chiral and prochiral organophosphate substrates by the phosphotriesterase from Sphingobium sp. TCM1
Biochemistry
57
1842-1846
2018
Sphingobium sp. TCM1 (A0A077JBW9)
Bigley, A.N.; Xiang, D.F.; Narindoshvili, T.; Burgert, C.W.; Hengge, A.C.; Raushel, F.M.
Transition State Analysis of the Reaction Catalyzed by the Phosphotriesterase from Sphingobium sp. TCM1
Biochemistry
58
1246-1259
2019
Sphingobium sp. TCM1 (A0A077JBW9)
Zuo, Z.; Gong, T.; Che, Y.; Liu, R.; Xu, P.; Jiang, H.; Qiao, C.; Song, C.; Yang, C.
Engineering Pseudomonas putida KT2440 for simultaneous degradation of organophosphates and pyrethroids and its application in bioremediation of soil
Biodegradation
26
223-233
2015
Stenotrophomonas sp. YC-1 (Q0PWQ4)
Nakayama, K.; Ohmori, T.; Ishikawa, S.; Iwata, N.; Seto, Y.; Kawahara, K.
Expression of recombinant organophosphorus hydrolase in the original producer of the enzyme, Sphingobium fuliginis ATCC 27551
Biosci. Biotechnol. Biochem.
80
1024-1026
2016
Sphingobium fuliginis (K4I2M6), Sphingobium fuliginis
Falahati-Pour, S.K.; Lotfi, A.S.; Ahmadian, G.; Baghizadeh, A.; Behroozi, R.; Haghighi, F.
High-level extracellular secretion of organophosphorous hydrolase of Flavobacterium sp. in Escherichia coli BL21(DE3)pLysS
Biotechnol. Appl. Biochem.
63
870-876
2016
Flavobacterium sp. MTCC 2495 (Q5UB52)
Del Giudice, I.; Coppolecchia, R.; Merone, L.; Porzio, E.; Carusone, T.M.; Mandrich, L.; Worek, F.; Manco, G.
An efficient thermostable organophosphate hydrolase and its application in pesticide decontamination
Biotechnol. Bioeng.
113
724-734
2016
Saccharolobus solfataricus (Q97VT7)
Restaino, O.F.; Borzacchiello, M.G.; Scognamiglio, I.; Fedele, L.; Alfano, A.; Porzio, E.; Manco, G.; De Rosa, M.; Schiraldi, C.
High yield production and purification of two recombinant thermostable phosphotriesterase-like lactonases from Sulfolobus acidocaldarius and Sulfolobus solfataricus useful as bioremediation tools and bioscavengers
BMC Biotechnol.
18
18
2018
Sulfolobus acidocaldarius, Saccharolobus solfataricus (Q97VT7)
Ashani, Y.; Leader, H.; Aggarwal, N.; Silman, I.; Worek, F.; Sussman, J.L.; Goldsmith, M.
Invitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for invivo protection against organophosphate intoxications
Chem. Biol. Interact.
259
252-256
2016
Pseudomonas sp., Brevundimonas diminuta (P0A434), Homo sapiens (P27169), Agrobacterium tumefaciens (Q93LD7)
Ponce-Ruiz, N.; Murillo-Gonzalez, F.E.; Rojas-Garcia, A.E.; Mackness, M.; Bernal-Hernandez, Y.Y.; Barron-Vivanco, B.S.; Gonzalez-Arias, C.A.; Medina-Diaz, I.M.
Transcriptional regulation of human paraoxonase 1 by nuclear receptors
Chem. Biol. Interact.
268
77-84
2017
Homo sapiens (P27169)
Le, Q.A.; Chang, R.; Kim, Y.H.
Rational design of paraoxonase 1 (PON1) for the efficient hydrolysis of organophosphates
Chem. Commun. (Camb.)
51
14536-14539
2015
Oryctolagus cuniculus (P27170)
Zsiros, N.; Koncsos, P.; Lorincz, H.; Seres, I.; Katko, M.; Szentpeteri, A.; Varga, V.E.; Fueloep, P.; Paragh, G.; Harangi, M.
Paraoxonase-1 arylesterase activity is an independent predictor of myeloperoxidase levels in overweight patients with or without cardiovascular complications
Clin. Biochem.
49
862-867
2016
Homo sapiens
Arulkumar, M.; Vijayan, R.; Penislusshiyan, S.; Sathishkumar, P.; Angayarkanni, J.; Palvannan, T.
Alteration of paraoxonase, arylesterase and lactonase activities in people around fluoride endemic area of Tamil Nadu, India
Clin. Chim. Acta
471
206-215
2017
Homo sapiens
Millenson, M.E.; Braun, J.M.; Calafat, A.M.; Barr, D.B.; Huang, Y.T.; Chen, A.; Lanphear, B.P.; Yolton, K.
Urinary organophosphate insecticide metabolite concentrations during pregnancy and childrens interpersonal, communication, repetitive, and stereotypic behaviors at 8 years of age the home study
Environ. Res.
157
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2017
Homo sapiens (P27169)
Bizon, A.; Milnerowicz, H.
The effect of divalent metal chelators and cadmium on serum phosphotriesterase, lactonase and arylesterase activities of paraoxonase 1
Environ. Toxicol. Pharmacol.
58
77-83
2018
Homo sapiens
Kahveci, H.; Laloglu, F.; Kilic, O.; Ciftel, M.; Yildirim, A.; Orbak, Z.; Ertekin, V.; Laloglu, E.
Serum paraoxonase and arylesterase values as antioxidants in healthy premature infants at fasting and posprandial times
Eur. Rev. Med. Pharmacol. Sci.
19
1761-1765
2015
Homo sapiens
Cebi, A.; Akgun, E.; Esen, R.; Demir, H.; Cifci, A.
The activities of serum paraoxonase and arylesterase and lipid profile in acute myeloid leukemia preliminary results
Eur. Rev. Med. Pharmacol. Sci.
19
4590-4594
2015
Homo sapiens
Zargari, M.; Sharafeddin, F.; Mahrooz, A.; Alizadeh, A.; Masoumi, P.
The common variant Q192R at the paraoxonase 1 (PON1) gene and its activity are responsible for a portion of the altered antioxidant status in type 2 diabetes
Exp. Biol. Med.
241
1489-1496
2016
Homo sapiens
Perla-Kajan, J.; Borowczyk, K.; Glowacki, R.; Nygard, O.; Jakubowski, H.
Paraoxonase 1 Q192R genotype and activity affect homocysteine thiolactone levels in humans
FASEB J.
32
6019
2018
Homo sapiens
Gudla, R.; Konduru, G.V.; Adimurty, N.H.; Siddavattam, D.
Organophosphate hydrolase interacts with Ton components and is targeted to the membrane only in the presence of the ExbB/ExbD complex
FEBS Lett.
593
581-593
2019
Sphingobium fuliginis (P0A433), Sphingobium fuliginis
Santillan, J.Y.; Dettorre, L.A.; Lewkowicz, E.S.; Iribarren, A.M.
New and highly active microbial phosphotriesterase sources
FEMS Microbiol. Lett.
363
fnw276
2016
Streptomyces phaeochromogenes, Pseudarthrobacter oxydans, Nocardia asteroides, Streptomyces griseus, Rhodococcus corynebacterioides, Brevundimonas diminuta (P0A434), Brevundimonas diminuta, Streptomyces phaeochromogenes CCRC 10811, Pseudarthrobacter oxydans ATCC 14358, Pseudarthrobacter oxydans ATCC 14359, Nocardia asteroides ATCC 19296, Rhodococcus corynebacterioides ATCC 14898, Streptomyces griseus ATCC 39116
Blaha-Nelson, D.; Krueger, D.M.; Szeler, K.; Ben-David, M.; Kamerlin, S.C.
Active site hydrophobicity and the convergent evolution of paraoxonase activity in structurally divergent enzymes the case of serum paraoxonase 1
J. Am. Chem. Soc.
139
1155-1167
2017
Oryctolagus cuniculus (P27170)
Parthasarathy, S.; Parapatla, H.; Nandavaram, A.; Palmer, T.; Siddavattam, D.
Organophosphate hydrolase is a lipoprotein and interacts with Pi-specific transport system to facilitate growth of Brevundimonas diminuta using OP insecticide as source of Phosphate
J. Biol. Chem.
291
7774-7785
2016
Brevundimonas diminuta (P0A434), Brevundimonas diminuta
Farnoosh, G.; Khajeh, K.; Latifi, A.M.; Aghamollaei, H.
Engineering and introduction of de novo disulphide bridges in organophosphorus hydrolase enzyme for thermostability improvement
J. Biosci.
41
577-588
2016
Brevundimonas diminuta (P0A434)
Zhang, H.; Yang, L.; Ma, Y.Y.; Zhu, C.; Lin, S.; Liao, R.Z.
Theoretical studies on catalysis mechanisms of serum paraoxonase 1 and phosphotriesterase diisopropyl fluorophosphatase suggest the alteration of substrate preference from paraoxonase to DFP
Molecules
23
1660
2018
Oryctolagus cuniculus (P27170)
Aggarwal, G.; Prajapati, R.; Tripathy, R.K.; Bajaj, P.; Iyengar, A.R.; Sangamwar, A.T.; Pande, A.H.
Toward understanding the catalytic mechanism of human paraoxonase 1 site-specific mutagenesis at position 192
PLoS ONE
11
e0147999
2016
Homo sapiens (P27169), Homo sapiens
Bajaj, P.; Tripathy, R.K.; Aggarwal, G.; Pande, A.H.
Expression and purification of biologically active recombinant human paraoxonase 1 from inclusion bodies of Escherichia coli
Protein Expr. Purif.
115
95-101
2015
Homo sapiens (P27169), Homo sapiens
Yun, H.; Yu, J.; Kim, S.; Lee, N.; Lee, J.; Lee, S.; Kim, N.D.; Yu, C.; Rho, J.
Expression and purification of biologically active recombinant human paraoxonase 1 from a Drosophila S2 stable cell line
Protein Expr. Purif.
131
34-41
2017
Homo sapiens (P27169)
Korkmaz, H.; Tabur, S.; Ozkaya, M.; Oguz, E.; Elboga, U.; Aksoy, N.; Akarsu, E.
Paraoxonase and arylesterase levels in autoimmune thyroid diseases
Redox Rep.
21
227-231
2016
Homo sapiens
Korkmaz, H.; Tabur, S.; Oezkaya, M.; Aksoy, N.; Yildiz, H.; Akarsu, E.
Paraoxonase and arylesterase activities in patients with papillary thyroid cancer
Scand. J. Clin. Lab. Invest.
75
259-264
2015
Homo sapiens
Remy, B.; Plener, L.; Poirier, L.; Elias, M.; Daude, D.; Chabriere, E.
Harnessing hyperthermostable lactonase from Sulfolobus solfataricus for biotechnological applications
Sci. Rep.
6
37780
2016
Saccharolobus solfataricus
Jacquet, P.; Hiblot, J.; Daude, D.; Bergonzi, C.; Gotthard, G.; Armstrong, N.; Chabriere, E.; Elias, M.
Rational engineering of a native hyperthermostable lactonase into a broad spectrum phosphotriesterase
Sci. Rep.
7
16745
2017
Saccharolobus solfataricus (Q97VT7), Saccharolobus solfataricus
Santillan, J.Y.; Dettorre, L.A.; Lewkowicz, E.S.; Iribarren, A.M.
New and highly active microbial phosphotriesterase sources
FEMS Microbiol. Lett.
363
fnw276
2016
Streptomyces phaeochromogenes, Pseudarthrobacter oxydans, Nocardia asteroides, Streptomyces griseus, Rhodococcus corynebacterioides, Brevundimonas diminuta (P0A434), Brevundimonas diminuta, Streptomyces phaeochromogenes CCRC 10811, Pseudarthrobacter oxydans ATCC 14358, Pseudarthrobacter oxydans ATCC 14359, Nocardia asteroides ATCC 19296, Rhodococcus corynebacterioides ATCC 14898, Streptomyces griseus ATCC 39116
Zhang, H.; Yang, L.; Ma, Y.Y.; Zhu, C.; Lin, S.; Liao, R.Z.
Theoretical studies on catalysis mechanisms of serum paraoxonase 1 and phosphotriesterase diisopropyl fluorophosphatase suggest the alteration of substrate preference from paraoxonase to DFP
Molecules
23
E1660
2018
Oryctolagus cuniculus (P27170)
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