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3.1.8.1: aryldialkylphosphatase

This is an abbreviated version!
For detailed information about aryldialkylphosphatase, go to the full flat file.

Word Map on EC 3.1.8.1

Reaction

An aryl dialkyl phosphate
+
H2O
=
dialkyl phosphate
 +
an aryl alcohol

Synonyms

A-esterase, A7Q26_23485, aminopeptidase P, AMPP, aryldialkylphosphatase, arylesterase, aryltriphosphatase, bacterial phosphotriesterase, DFPase, diisopropyl fluorophosphatase, esterase B1, esterase E4, esterase, organophosphate, esterase, paraoxon, esterase, pirimiphos-methyloxon, G3C9 rePON1, h-PON1, HAD, haloalkylphosphorus hydrolase, HDL-associated esterase/lactonase paraoxonase 1, HDL-PON1, high activity paraoxonase, high-density lipoprotein-associated esterase/lactonase, human paraoxonase 1, HuPON1, inner membrane protein YiaH, lactonase SsoPox, lactonase/phosphotriesterase, low activity paraoxonase, methyl parathion hydrolase, More, Mph, mPHP, OP hydrolase, OP-hydrolase, OP-hydrolyzing enzyme, OPA anhydrase, opd, OpdA, OpdD, OPH, OPHC2, organophosphate hydrolase, organophosphorous hydrolase, organophosphorus acid anhydrase, organophosphorus hydrolase, organophosphorus pesticide hydrolase, organophosphorus-hydrolyzing enzyme, paraoxon hydrolase, paraoxonase, paraoxonase 1, paraoxonase 1A, paraoxonase 3, paraoxonase-1, paraoxonase-2, paraoxonase1, parathion hydrolase, phosphotriesterase, phosphotriesterase homology protein, phosphotriesterase-like lactonase, PHP, pirimiphos-methyloxon esterase, PLL, PO.ase, PON, PON 1, PON-1, PON-aryl, PON-para, PON1, PON1A, PON2, PON3, POX, PTE, PTE S5, Rv0230c, SACI2140, Saci_2140, SacPox, Sb-PTE, serum paraoxonase, serum paraoxonase 1, SisLac, SisPox, Sso, SSO2522, SsoPox, type A paraoxonase, type B paraoxonase, VmoLac, Vmut2255, VmutPLL

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.8 Phosphoric-triester hydrolases
                3.1.8.1 aryldialkylphosphatase

KI Value

KI Value on EC 3.1.8.1 - aryldialkylphosphatase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.008
6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one
-
pH 10.5, 37°C
0.0003
6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one
-
pH 10.5, 37°C
0.001
6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one
-
pH 10.5, 37°C
0.093
6,7-dihydroxycoumarin
-
pH 10.5, 37°C
0.0012
cefazolin
-
pH 8.0, 37°C, serum PON1, versus paraoxon
0.805
diclofenac sodium
-
in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C
0.25 - 0.99
diethyl 4-methylbenzylphosphonate
0.192 - 4.49
diethyl-paraoxon
0.44
diisopropylfluorophosphate
pH 8.5, 25°C, wild-type enzyme, substrate paraoxon
0.059
etomidate
in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C
1.23
fensulfothion
70°C, pH 9.0
0.026
gentamycin sulfate
-
pH 8.0, 37°C, serum PON1
0.097
indomethacin
-
in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C
6.48
Ketamine
in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C
13.01
Ketoprofen
-
in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C
11.12
lincomycine
-
in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C
0.009
lornoxicam
-
in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C
3
NiCl2
Co2+-PTE, at pH 8.5 and 30°C, with paraoxon as substrate
0.041
palmitoyl-lysophosphatidylglycerol
pH 7.4, 25°C
0.47 - 1.95
phenyl acetate
0.322
propofol
in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C
0.306
tenoxicam
-
in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C
0.052 - 0.63
ZnCl2
additional information
additional information
-
in vivo and in vitro inhibition kinetic analysis, overview
-