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3.1.8.1: aryldialkylphosphatase

This is an abbreviated version!
For detailed information about aryldialkylphosphatase, go to the full flat file.

Word Map on EC 3.1.8.1

Reaction

An aryl dialkyl phosphate
+
H2O
=
dialkyl phosphate
 +
an aryl alcohol

Synonyms

A-esterase, A7Q26_23485, aminopeptidase P, AMPP, aryldialkylphosphatase, arylesterase, aryltriphosphatase, bacterial phosphotriesterase, DFPase, diisopropyl fluorophosphatase, esterase B1, esterase E4, esterase, organophosphate, esterase, paraoxon, esterase, pirimiphos-methyloxon, G3C9 rePON1, h-PON1, HAD, haloalkylphosphorus hydrolase, HDL-associated esterase/lactonase paraoxonase 1, HDL-PON1, high activity paraoxonase, high-density lipoprotein-associated esterase/lactonase, human paraoxonase 1, HuPON1, inner membrane protein YiaH, lactonase SsoPox, lactonase/phosphotriesterase, low activity paraoxonase, methyl parathion hydrolase, More, Mph, mPHP, OP hydrolase, OP-hydrolase, OP-hydrolyzing enzyme, OPA anhydrase, opd, OpdA, OpdD, OPH, OPHC2, organophosphate hydrolase, organophosphorous hydrolase, organophosphorus acid anhydrase, organophosphorus hydrolase, organophosphorus pesticide hydrolase, organophosphorus-hydrolyzing enzyme, paraoxon hydrolase, paraoxonase, paraoxonase 1, paraoxonase 1A, paraoxonase 3, paraoxonase-1, paraoxonase-2, paraoxonase1, parathion hydrolase, phosphotriesterase, phosphotriesterase homology protein, phosphotriesterase-like lactonase, PHP, pirimiphos-methyloxon esterase, PLL, PO.ase, PON, PON 1, PON-1, PON-aryl, PON-para, PON1, PON1A, PON2, PON3, POX, PTE, PTE S5, Rv0230c, SACI2140, Saci_2140, SacPox, Sb-PTE, serum paraoxonase, serum paraoxonase 1, SisLac, SisPox, Sso, SSO2522, SsoPox, type A paraoxonase, type B paraoxonase, VmoLac, Vmut2255, VmutPLL

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.8 Phosphoric-triester hydrolases
                3.1.8.1 aryldialkylphosphatase

General Stability

General Stability on EC 3.1.8.1 - aryldialkylphosphatase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
addition of di-oleoyl phosphatidylcholine to serum stabilizes PON1 activity and protects PON1 from nitrilotriacetic acid-induced inactivation
association of paraoxonase 1 with high-density lipoprotein stabilizes the enzyme
efficient enzyme-catalyzed hydrolysis of OPC requires essential stabilization of the enzyme in the acidic pH region
-
human paraoxonase 1 alone is unstable. But it is stabilized by the presence of its most common partner protein, the human phosphate binding protein
-
human phosphate-binding protein stabilizes the enzyme and its conformations
-
loss of activity after dialysis
-
nanocapsulation of enzyme into enzyme-polyelectrolyte complexes leads to its expected stabilisation and significant improvement of Km and Ksi with methylphosphonic acid
stable for up to 40 h in 0.2% SDS at 25°C
the HDL composition has an influence on the enzyme stability, overview
-
the hydrophobic poly(propylene oxide) blocks of Pluronic interact with hydrophobic amino acids of the enzyme, resulting in an increased activity and pot life for dilute concentrations, methanol inhibition, enhanced stability against high temperature, and extended shelf life
-
with the liquid enzyme, the remaining activity decreases down to 40% at the highest dose of beta-radiation (100 kGy)
-