3.1.8.1: aryldialkylphosphatase

This is an abbreviated version!
For detailed information about aryldialkylphosphatase, go to the full flat file.

Reaction

Synonyms

A-esterase, A7Q26_23485, aminopeptidase P, AMPP, aryldialkylphosphatase, arylesterase, aryltriphosphatase, bacterial phosphotriesterase, DFPase, diisopropyl fluorophosphatase, esterase B1, esterase E4, esterase, organophosphate, esterase, paraoxon, esterase, pirimiphos-methyloxon, G3C9 rePON1, h-PON1, HAD, haloalkylphosphorus hydrolase, HDL-associated esterase/lactonase paraoxonase 1, HDL-PON1, high activity paraoxonase, high-density lipoprotein-associated esterase/lactonase, human paraoxonase 1, HuPON1, inner membrane protein YiaH, lactonase SsoPox, lactonase/phosphotriesterase, low activity paraoxonase, methyl parathion hydrolase, More, Mph, mPHP, OP hydrolase, OP-hydrolase, OP-hydrolyzing enzyme, OPA anhydrase, opd, OpdA, OpdD, OPH, OPHC2, organophosphate hydrolase, organophosphorous hydrolase, organophosphorus acid anhydrase, organophosphorus hydrolase, organophosphorus pesticide hydrolase, organophosphorus-hydrolyzing enzyme, paraoxon hydrolase, paraoxonase, paraoxonase 1, paraoxonase 1A, paraoxonase 3, paraoxonase-1, paraoxonase-2, paraoxonase1, parathion hydrolase, phosphotriesterase, phosphotriesterase homology protein, phosphotriesterase-like lactonase, PHP, pirimiphos-methyloxon esterase, PLL, PO.ase, PON, PON 1, PON-1, PON-aryl, PON-para, PON1, PON1A, PON2, PON3, POX, PTE, PTE S5, Rv0230c, SACI2140, Saci_2140, SacPox, Sb-PTE, serum paraoxonase, serum paraoxonase 1, SisLac, SisPox, Sso, SSO2522, SsoPox, type A paraoxonase, type B paraoxonase, VmoLac, Vmut2255, VmutPLL

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.8 Phosphoric-triester hydrolases

                3.1.8.1 aryldialkylphosphatase

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Results	in table
54	Activating Compound
212	AA Sequence
57	Application
1	CAS Registry Number
85	Cloned(Commentary)
19	Crystallization (Commentary)
1616	Disease/ Diagnostics
13	Expression
54	General Information
11	General Stability
51	IC50 Value
196	Inhibitors
260	kcat/KM [mM/s]
38	Ki Value [mM]
360	KM Value [mM]
38	Localization
136	Metals/Ions
65	Molecular Weight [Da]
113	Natural Substrates/ Products (Substrates)
7	Organic Solvent Stability
421	Organism
3	Oxidation Stability
8	Pathway
200	PDB ID
102	pH Optimum
17	pH Range
6	pH Stability
9	pI Value
16	Posttranslational Modification
368	Protein Variants
100	Purification (Commentary)
22	Reaction
1	Reaction Type
333	Reference
7	Renatured (Commentary)
205	Source Tissue
98	Specific Activity [micromol/min/mg]
17	Storage Stability
879	Substrates and Products (Substrate)
105	Subunits
475	Synonyms
1	Systematic Name
87	Temperature Optimum [°C]
11	Temperature Range [°C]
57	Temperature Stability [°C]
370	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.1.8.1 - aryldialkylphosphatase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.012

6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one

Homo sapiens

-

pH 10.5, 37°C

728992

0.022

6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one

Homo sapiens

-

pH 10.5, 37°C

728992

0.003

6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one

Homo sapiens

-

pH 10.5, 37°C

728992

0.178

6,7-dihydroxycoumarin

Homo sapiens

-

pH 10.5, 37°C

728992

0.1 - 0.5

bis(cyclopropylmethyl) phosphoramidate

synthetic construct

-

pH 7.4, temperature not specified in the publication

730265

0.3

bis[4-(methylsulfanyl)phenyl] phosphorazidate

synthetic construct

-

pH 7.4, temperature not specified in the publication

730265

0.152 - 0.73

Cd2+

3 entries

0.0084

cefazolin

Homo sapiens

-

pH 8.0, 37°C, serum PON1

678489

0.781 - 3.91

Co2+

2 entries

0.08 - 0.28

Co3+

2 entries

0.0026 - 1.5

Cu2+

6 entries

0.03

dibenzyl phosphoramidate

synthetic construct

-

pH 7.4, temperature not specified in the publication

730265

1.639

diclofenac sodium

Homo sapiens

-

in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C

709291

0.021

etomidate

Homo sapiens

P27169

in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C

691848

0.887

gentamycin sulfate

Homo sapiens

-

pH 8.0, 37°C, serum PON1

678489

0.002 - 0.891

Hg2+

5 entries

0.195

indomethacin

Homo sapiens

-

in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C

709291

3.8

Ketamine

Homo sapiens

P27169

in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C

691848

6.23

Ketoprofen

Homo sapiens

-

in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C

709291

9.638

lincomycine

Homo sapiens

-

in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C

709291

0.136

lornoxicam

Homo sapiens

-

in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C

709291

2.3 - 5

Mg2+

2 entries

0.0012 - 0.609

Mn2+

5 entries

0.099 - 2

Ni2+

4 entries

0.049

Pb2+

Bos taurus

-

pH 8.0, 37°C

729353

0.328

propofol

Homo sapiens

P27169

in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C

691848

0.34

tenoxicam

Homo sapiens

-

in 50 mM glycine/NaOH, pH 10.5, 1 mM CaCl2, at 25°C

709291

0.043

Zn2+

Bos taurus

-

pH 8.0, 37°C

729353

0.53

ZnCl2

Brevundimonas diminuta

P0A434

Co2+-PTE, at pH 8.5 and 30°C, with O,O-(3-chloro-4-methyl-2-oxo-2H-chromen-7-yl)ethylmethylphosphonate as substrate

709292

additional information

additional information

Homo sapiens

-

-

678489

-

0.152

Cd2+

Homo sapiens

-

R192 isoenzyme, pH 8 at 25°C

709262

0.218

Cd2+

Homo sapiens

-

Q192 isoenzyme, pH 8 at 25°C

709262

0.73

Cd2+

Scyliorhinus canicula

-

pH 8.0, 37°C

715747

0.781

Co2+

Homo sapiens

-

R192 isoenzyme, pH 8 at 25°C

709262

3.91

Co2+

Homo sapiens

-

Q192 isoenzyme, pH 8 at 25°C

709262

0.08

Co3+

Rattus norvegicus

-

pH 8.5, 37°C, enzyme form M2

646521

0.28

Co3+

Rattus norvegicus

-

pH 8.5, 37°C, enzyme form M1

646521

0.0026

Cu2+

Bos taurus

-

pH 8.0, 37°C

729353

0.061

Cu2+

Homo sapiens

-

R192 isoenzyme, pH 8 at 25°C

709262

0.29

Cu2+

Scyliorhinus canicula

-

pH 8.0, 37°C

715747

0.31

Cu2+

Homo sapiens

-

Q192 isoenzyme, pH 8 at 25°C

709262

0.6

Cu2+

Rattus norvegicus

-

pH 8.5, 37°C, enzyme form M2

646521

1.5

Cu2+

Rattus norvegicus

-

pH 8.5, 37°C, enzyme form M1

646521

0.002

Hg2+

Rattus norvegicus

-

pH 8.5, 37°C, enzyme form M2

646521

0.014

Hg2+

Rattus norvegicus

-

pH 8.5, 37°C, enzyme form M1

646521

0.106

Hg2+

Homo sapiens

-

R192 isoenzyme, pH 8 at 25°C

709262

0.49

Hg2+

Scyliorhinus canicula

-

pH 8.0, 37°C

715747

0.891

Hg2+

Homo sapiens

-

Q192 isoenzyme, pH 8 at 25°C

709262

2.3

Mg2+

Rattus norvegicus

-

pH 8.5, 37°C, enzyme form M2

646521

5

Mg2+

Rattus norvegicus

-

pH 8.5, 37°C, enzyme form M1

646521

0.0012

Mn2+

Bos taurus

-

pH 8.0, 37°C

729353

0.09

Mn2+

Rattus norvegicus

-

pH 8.5, 37°C, enzyme form M2

646521

0.2

Mn2+

Rattus norvegicus

-

pH 8.5, 37°C, enzyme form M1

646521

0.304

Mn2+

Homo sapiens

-

R192 isoenzyme, pH 8 at 25°C

709262

0.609

Mn2+

Homo sapiens

-

Q192 isoenzyme, pH 8 at 25°C

709262

0.099

Ni2+

Bos taurus

-

pH 8.0, 37°C

729353

1.026

Ni2+

Homo sapiens

-

R192 isoenzyme, pH 8 at 25°C

709262

1.144

Ni2+

Homo sapiens

-

Q192 isoenzyme, pH 8 at 25°C

709262

2

Ni2+

Scyliorhinus canicula

-

pH 8.0, 37°C

715747