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Literature summary for 3.1.8.1 extracted from

  • Dedeoglu, N.; Arslan, M.; Erzengin, M.
    Purification of Holstein bull semen paraoxonase 1 (PON1) by hydrophobic interaction chromatography and investigation of its inhibition kinetics by heavy metals (2014), Biol. Trace Elem. Res., 158, 29-35.
    View publication on PubMed
Search for more literature for 3.1.8.1

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
 Bos taurus
Mn2+
-
 Bos taurus
Ni2+
-
 Bos taurus
Pb2+
-
 Bos taurus
Zn2+
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.08
-
 paraoxon pH 8.0, 37°C Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ 2 microM, 180% of initial activity Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
 x * 66000, SDS-PAGE Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
semen
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
288
-
 pH 8.0, 37°C Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
paraoxon + H2O
-
 Bos taurus 4-nitrophenol + diethyl phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 66000, SDS-PAGE Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0012
-
 pH 8.0, 37°C Bos taurus Mn2+
0.0026
-
 pH 8.0, 37°C Bos taurus Cu2+
0.043
-
 pH 8.0, 37°C Bos taurus Zn2+
0.049
-
 pH 8.0, 37°C Bos taurus Pb2+
0.099
-
 pH 8.0, 37°C Bos taurus Ni2+